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Apoh
Gene Detail
Symbol

Name
ID
Apoh
apolipoprotein H
MGI:88058
Synonyms
B2GPI, beta-2-glycoprotein 1, beta-2-GPI
Feature Type
protein coding gene
Genetic Map
Chromosome 11
71.80 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:108343354-108414396 bp, + strand
From VEGA annotation of GRCm38

  71043 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:26  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Apoh

Human
homologs
Human Homolog APOH, apolipoprotein H (beta-2-glycoprotein I)
NCBI Gene ID 350
neXtProt AC  NX_P02749
Human Synonyms  B2G1, B2GP1, BG
Human Chr (Location)  17q24.2; chr17:66212029-66229438 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in reduced viability and reduced thrombin production. Only 8% homozygous null animals are born from heterozygous intercrosses.
 
Interactions
Apoh interacts with 26 markers (Mir31, Mir138-2, Mir181a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process blood coagulation, blood coagulation, intrinsic pathway, ...
Component cell surface, chylomicron, ...
Function glycoprotein binding, heparin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (42)    Tissues (1)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 42
cDNA source data(185)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(189) Genomic(1) cDNA(186) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000003129 (Evidence)
Ensembl Gene ModelENSMUSG00000000049 (Evidence)
Entrez Gene11818 (Evidence)
UniGene2266
DFCITC1574638, TC1688194
DoTSDT.101232373, DT.55107469
NIA Mouse Gene IndexU013484
Consensus CDS ProjectCCDS25574.1
International Mouse Knockout Project StatusApoh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003129 VEGA Gene Model | MGI Sequence Detail 71043 C57BL/6J ±  kb
transcript OTTMUST00000006445 VEGA | MGI Sequence Detail 1190 Not Applicable 
polypeptide OTTMUSP00000003033 VEGA | MGI Sequence Detail 345 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(4) UniProt(9)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(328 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015104 Beta-2-glycoprotein-1 fifth domain
InterPro IPR000436 Sushi/SCR/CCP
Protein Ontology PR:000004157 beta-2-glycoprotein 1
References
(Earliest) J:1723 Nonaka M, et al., Molecular cloning of mouse beta 2-glycoprotein I and mapping of the gene to chromosome 11. Genomics. 1992 Aug;13(4):1082-7
(Latest) J:208341 Seth A, et al., Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development. 2014 Feb;141(3):538-47
All references(39)
Other
accession IDs
MGD-MRK-1377

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory