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Apoc1
Gene Detail
Symbol

Name
ID
Apoc1
apolipoprotein C-I
MGI:88053
Feature Type
protein coding gene
Genetic Map
Chromosome 7
9.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr7:19689484-19692658 bp, - strand
From Ensembl annotation of GRCm38

  3175 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:136426  Vertebrate Homology Class
1 mouse; 1 rat; 1 dog

Gene Tree: Apoc1

Mutations,
alleles, and
phenotypes
All mutations/alleles(40) : Gene trapped(35) Targeted(3) Transgenic(2)
 
Mice homozygous for a knock-out allele exhibit normal serum lipid levels on a chow diet, develop hypercholesterolemia only when fed a high-fat/high-cholesterol diet, and show significant increases in the liver content of cholesteryl esters and triglycerides and in biliary cholesterol concentration.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Apoc1 interacts with 5 markers (Mir190b, Mir205, Mir207, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cholesterol metabolic process, lipid transport, ...
Component extracellular region, very-low-density lipoprotein particle
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (11)    Tissues (10)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 9
RT-PCR 2
cDNA source data(149)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(153) Genomic(1) cDNA(150) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000040564 (Evidence)
Entrez Gene 11812 (Evidence)
UniGene 182440
DFCI TC1575677, TC1708011
DoTS DT.101232306, DT.101704544
NIA Mouse Gene Index U028236
Consensus CDS Project CCDS39802.1
International Mouse Phenotyping Consortium Status Apoc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040564 Ensembl Gene Model | MGI Sequence Detail 3175 C57BL/6J ±  kb
transcript ENSMUST00000045035 Ensembl | MGI Sequence Detail 427 Not Applicable 
polypeptide ENSMUSP00000045571 Ensembl | MGI Sequence Detail 88 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006781 Apolipoprotein C-I
Protein Ontology PR:000004150 apolipoprotein C-I
References
(Earliest) J:24996 Mahley RW, et al., Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res. 1984 Dec 1;25(12):1277-94
(Latest) J:143183 de Haan W, et al., Apolipoprotein CI inhibits scavenger receptor BI and increases plasma HDL levels in vivo. Biochem Biophys Res Commun. 2008 Dec 26;377(4):1294-8
All references(49)
Other
accession IDs
MGD-MRK-1372

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory