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Apoa4
Gene Detail
Symbol

Name
ID
Apoa4
apolipoprotein A-IV
MGI:88051
Synonyms
Apoa-4
Feature Type
protein coding gene
Genetic Map
Chromosome 9
25.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr9:46240696-46243459 bp, + strand
From VEGA annotation of GRCm38

  2764 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47927  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 5 zebrafish

Gene Tree: Apoa4

Human
homologs
Human Homolog APOA4, apolipoprotein A-IV
NCBI Gene ID 337
neXtProt AC  NX_P06727
Human Chr (Location)  11q23; chr11:116820702-116823295 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Genomic Mutations involving Apoa4 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruption of this gene have lower HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Apoa4 interacts with 43 markers (Mir93, Mir125a, Mir133a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process cholesterol efflux, cholesterol homeostasis, ...
Component blood microparticle, cell surface, ...
Function antioxidant activity, cholesterol transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (18)    Tissues (14)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 10
RT-PCR 8
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(3) cDNA(17) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000028705 (Evidence)
Ensembl Gene ModelENSMUSG00000032080 (Evidence)
Entrez Gene11808 (Evidence)
DFCITC1572402, TC1596818, TC1607455, TC1749048, TC1757125
NIA Mouse Gene IndexU010435
Consensus CDS ProjectCCDS23142.1
International Mouse Knockout Project StatusApoa4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028705 VEGA Gene Model | MGI Sequence Detail 2764 C57BL/6J ±  kb
transcript OTTMUST00000071089 VEGA | MGI Sequence Detail 1815 Not Applicable 
polypeptide OTTMUSP00000036353 VEGA | MGI Sequence Detail 395 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000074 Apolipoprotein A1/A4/E
Protein Ontology PR:000004143 apolipoprotein A-IV
References
(Earliest) J:24996 Mahley RW, et al., Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res. 1984 Dec 1;25(12):1277-94
(Latest) J:209530 Li X, et al., Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1. J Biol Chem. 2014 Jan 24;289(4):2396-404
All references(73)
Other
accession IDs
MGD-MRK-1366, MGD-MRK-1369

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory