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Apoa4
Gene Detail
Symbol

Name
ID
Apoa4
apolipoprotein A-IV
MGI:88051
Synonyms
Apoa-4
Feature Type
protein coding gene
Genetic Map
Chromosome 9
25.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr9:46240696-46243459 bp, + strand
From VEGA annotation of GRCm38

  2764 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47927  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 5 zebrafish

HCOP human homology predictions: APOA4
Gene Tree: Apoa4

Human
homologs
APOA4, apolipoprotein A-IV
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 337
neXtProt AC: NX_P06727

Human Chr (Location): 11q23; chr11:116820702-116823295 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Genomic Mutations involving Apoa4 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruption of this gene have lower HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Apoa4 interacts with 43 markers (Mir93, Mir125a, Mir133a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process cholesterol biosynthetic process, cholesterol efflux, ...
Component blood microparticle, cell surface, ...
Function antioxidant activity, cholesterol binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (18)    Tissues (14)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 10
RT-PCR 8
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase apoa4 ; ZFIN apoa4a, apoa4b.1, apoa4b.2, apoa4b.3    NEW 
Molecular
reagents
All nucleic(22) Genomic(3) cDNA(17) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000028705 (Evidence)
Ensembl Gene Model ENSMUSG00000032080 (Evidence)
Entrez Gene 11808 (Evidence)
DFCI TC1572402, TC1596818, TC1607455, TC1749048, TC1757125
NIA Mouse Gene Index U010435
Consensus CDS Project CCDS23142.1
International Mouse Phenotyping Consortium Status Apoa4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028705 VEGA Gene Model | MGI Sequence Detail 2764 C57BL/6J ±  kb
transcript OTTMUST00000071089 VEGA | MGI Sequence Detail 1815 Not Applicable 
polypeptide OTTMUSP00000036353 VEGA | MGI Sequence Detail 395 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000074 Apolipoprotein A1/A4/E
Protein Ontology PR:000004143 apolipoprotein A-IV
References
(Earliest) J:24996 Mahley RW, et al., Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res. 1984 Dec 1;25(12):1277-94
(Latest) J:214986 Walker EM, et al., GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development. Dev Biol. 2014 Aug 15;392(2):283-94
All references(73)
Other
accession IDs
MGD-MRK-1366, MGD-MRK-1369

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory