Apoa4
Gene Detail

Symbol Name ID

Apoa4 apolipoprotein A-IV MGI:88051

Synonyms

Apoa-4

Feature Type

protein coding gene

Genetic Map

Chromosome 9

25.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr9:46240696-46243459 bp, + strand From VEGA annotation of GRCm38   2764 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; pig, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Apoa4 ± 2 cM)

Gene Tree: Apoa4

Human ortholog

APOA4 apolipoprotein A-IV NCBI Gene ID 337
Human Chr11:116691418-116694011 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for disruption of this gene have lower HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior.

 
Human Diseases Modeled Using Mouse Apoa4 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (41 annotations)

Process	cholesterol efflux, cholesterol homeostasis, ...
Component	chylomicron, extracellular region, ...
Function	antioxidant activity, cholesterol transporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (8)    Tissues (4)    Images (1)
Theiler Stages: 15, 22, 24, 26

Assay Type	Results
RT-PCR	8

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(3) cDNA(16) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000028705 (Evidence)
Ensembl Gene Model	ENSMUSG00000032080 (Evidence)
Entrez Gene	11808 (Evidence)
DFCI	TC1572402, TC1596818, TC1607455, TC1749048, TC1757125
NIA Mouse Gene Index	U010435
Consensus CDS Project	CCDS23142.1
International Mouse Knockout Project Status	Apoa4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028705	VEGA Gene Model | MGI Sequence Detail	2764	C57BL/6J
transcript	OTTMUST00000071089	VEGA | MGI Sequence Detail	1815	Not Applicable
polypeptide	OTTMUSP00000036353	VEGA | MGI Sequence Detail	395	Not Applicable

All sequences(31) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(33 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000074	Apolipoprotein A1/A4/E
InterPro	IPR013326	Apolipoprotein/apolipophorin
Protein Ontology	PR:000004143	apolipoprotein A-IV

References

(Earliest) J:24996 Mahley RW, et al., Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res. 1984 Dec 1;25(12):1277-94
(Latest) J:191161 Yoshimichi G, et al., Effect of peripheral administration of cholecystokinin on food intake in apolipoprotein AIV knockout mice. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 1;302(11):G1336-42
All references(69)

Other accession IDs

MGD-MRK-1366, MGD-MRK-1369