Aplp1
Gene Detail

Symbol

Name
ID

Aplp1
amyloid beta (A4) precursor-like protein 1
MGI:88046

Feature Type

protein coding gene

Genetic Map

Chromosome 7
18.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:30434981-30445582 bp, - strand From Ensembl annotation of GRCm38   10602 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:68447  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Aplp1

Human
homologs

Human Homolog		APLP1, amyloid beta (A4) precursor-like protein 1
NCBI Gene ID		333
neXtProt AC		NX_P51693
Human Synonyms		APLP
Human Chr (Location)		19q13.1; chr19:35868499-35879797 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(12) : Gene trapped(9) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Animals homozygous for a mutation in this gene show a 10% decrease in body weight at 9 weeks of age.

 

Interactions

Aplp1 interacts with 74 markers (Mir1b, Mir7b, Mir18, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (28 annotations)

Process	apoptotic process, cell adhesion, ...
Component	cytoplasm, Golgi apparatus, ...
Function	alpha-2A adrenergic receptor binding, alpha-2B adrenergic receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)

Data Summary: Results (150)    Tissues (56)    Images (33)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	136
Northern blot	8
RT-PCR	6

cDNA source data(84)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(88) Genomic(1) cDNA(85) Primer pair(2)
Microarray probesets(3)

Other database
links

Ensembl Gene Model	ENSMUSG00000006651 (Evidence)
Entrez Gene	11803 (Evidence)
UniGene	2381
DFCI	TC1572842
DoTS	DT.532055, DT.94201377
NIA Mouse Gene Index	U028382
Consensus CDS Project	CCDS21092.1
International Mouse Knockout Project Status	Aplp1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000006651	Ensembl Gene Model | MGI Sequence Detail	10602	C57BL/6J
transcript	ENSMUST00000006828	Ensembl | MGI Sequence Detail	2391	Not Applicable
polypeptide	ENSMUSP00000006828	Ensembl | MGI Sequence Detail	654	Not Applicable

All sequences(23) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs within 2kb(196 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR008155	Amyloidogenic glycoprotein
InterPro	IPR011178	Amyloidogenic glycoprotein, copper-binding
InterPro	IPR024329	Amyloidogenic glycoprotein, E2 domain
InterPro	IPR008154	Amyloidogenic glycoprotein, extracellular
InterPro	IPR019744	Amyloidogenic glycoprotein, extracellular domain conserved site
InterPro	IPR015849	Amyloidogenic glycoprotein, heparin-binding
InterPro	IPR019745	Amyloidogenic glycoprotein, intracellular domain, conserved site
InterPro	IPR019543	Beta-amyloid precursor protein C-terminal
Protein Ontology	PR:000004136	amyloid-like protein 1

References

(Earliest) J:3302 Wasco W, et al., Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10758-62
(Latest) J:214098 Klevanski M, et al., Differential role of APP and APLPs for neuromuscular synaptic morphology and function. Mol Cell Neurosci. 2014 Jul;61:201-10
All references(51)

Other
accession IDs

MGD-MRK-1360