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Aplp1
Gene Detail
Symbol

Name
ID
Aplp1
amyloid beta (A4) precursor-like protein 1
MGI:88046
Feature Type
protein coding gene
Genetic Map
Chromosome 7
18.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:30434981-30445582 bp, - strand
From Ensembl annotation of GRCm38

  10602 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68447  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Aplp1

Human
homologs
Human Homolog APLP1, amyloid beta (A4) precursor-like protein 1
NCBI Gene ID 333
neXtProt AC  NX_P51693
Human Synonyms  APLP
Human Chr (Location)  19q13.1; chr19:35868499-35879797 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(9) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Animals homozygous for a mutation in this gene show a 10% decrease in body weight at 9 weeks of age.
 
Interactions
Aplp1 interacts with 74 markers (Mir1b, Mir7b, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process apoptotic process, cell adhesion, ...
Component cytoplasm, Golgi apparatus, ...
Function alpha-2A adrenergic receptor binding, alpha-2B adrenergic receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (150)    Tissues (56)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 136
Northern blot 8
RT-PCR 6
cDNA source data(84)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(88) Genomic(1) cDNA(85) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000006651 (Evidence)
Entrez Gene11803 (Evidence)
UniGene2381
DFCITC1572842
DoTSDT.532055, DT.94201377
NIA Mouse Gene IndexU028382
Consensus CDS ProjectCCDS21092.1
International Mouse Knockout Project StatusAplp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006651 Ensembl Gene Model | MGI Sequence Detail 10602 C57BL/6J ±  kb
transcript ENSMUST00000006828 Ensembl | MGI Sequence Detail 2391 Not Applicable 
polypeptide ENSMUSP00000006828 Ensembl | MGI Sequence Detail 654 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(196 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008155 Amyloidogenic glycoprotein
InterPro IPR011178 Amyloidogenic glycoprotein, copper-binding
InterPro IPR024329 Amyloidogenic glycoprotein, E2 domain
InterPro IPR008154 Amyloidogenic glycoprotein, extracellular
InterPro IPR019744 Amyloidogenic glycoprotein, extracellular domain conserved site
InterPro IPR015849 Amyloidogenic glycoprotein, heparin-binding
InterPro IPR019745 Amyloidogenic glycoprotein, intracellular domain, conserved site
InterPro IPR019543 Beta-amyloid precursor protein C-terminal
Protein Ontology PR:000004136 amyloid-like protein 1
References
(Earliest) J:3302 Wasco W, et al., Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10758-62
(Latest) J:214098 Klevanski M, et al., Differential role of APP and APLPs for neuromuscular synaptic morphology and function. Mol Cell Neurosci. 2014 Jul;61:201-10
All references(51)
Other
accession IDs
MGD-MRK-1360

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory