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Aplp1 Gene Detail
Summary
  • Symbol
    Aplp1
  • Name
    amyloid beta (A4) precursor-like protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88046
    NCBI Gene: 11803
  • Gene Overview
    MyGene.info: APLP1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr7:30434982-30445535 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      10554 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 18.32 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    APLP1, amyloid beta precursor like protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    APLP1, amyloid beta precursor like protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APLP
  • Links
    NCBI Gene ID: 333
    neXtProt AC: NX_P51693
    UniProt: P51693

  • Chr Location
    19q13.12; chr19:35868445-35879797 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Animals homozygous for a mutation in this gene show a 10% decrease in body weight at 9 weeks of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    150
  • Tissues
    56
  • cDNA Data
    84
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000059360 VEGA Gene Model | MGI Sequence Detail 10554 C57BL/6J ±  kb
    transcript OTTMUST00000145710 VEGA | MGI Sequence Detail 2343 Not Applicable  
    polypeptide OTTMUSP00000075915 VEGA | MGI Sequence Detail 654 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      175 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR008155 Amyloidogenic glycoprotein
      IPR011178 Amyloidogenic glycoprotein, copper-binding
      IPR036669 Amyloidogenic glycoprotein, copper-binding domain superfamily
      IPR024329 Amyloidogenic glycoprotein, E2 domain
      IPR008154 Amyloidogenic glycoprotein, extracellular
      IPR019744 Amyloidogenic glycoprotein, extracellular domain conserved site
      IPR015849 Amyloidogenic glycoprotein, heparin-binding
      IPR036454 Amyloidogenic glycoprotein, heparin-binding domain superfamily
      IPR019745 Amyloidogenic glycoprotein, intracellular domain, conserved site
      IPR019543 Beta-amyloid precursor protein C-terminal
      IPR036176 E2 domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 1
      cDNA 85
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1360
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 12
      Gene Ontology 12
      Phenotypes 12
    • Earliest
      J:3302 Wasco W, et al., Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10758-62
    • Latest
      J:242215 Schilling S, et al., APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission. J Neurosci. 2017 May 24;37(21):5345-5365
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/08/2018
    MGI 6.12     		The Jackson Laboratory