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Aplp1 Gene Detail
Summary
  • Symbol
    Aplp1
  • Name
    amyloid beta (A4) precursor-like protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88046
    NCBI Gene: 11803
Location & Maps
more
  • Sequence Map
    Chr7:30434981-30445582 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10602 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    APLP1, amyloid beta precursor like protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    APLP1, amyloid beta precursor like protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    APLP
  • Links
    NCBI Gene ID: 333
    neXtProt AC: NX_P51693

  • Chr Location
    19q13.1; chr19:35868499-35879797 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Gene trapped
    9
  • Targeted
    3
  • Incidental Mutations
Animals homozygous for a mutation in this gene show a 10% decrease in body weight at 9 weeks of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006651 Ensembl Gene Model | MGI Sequence Detail 10602 C57BL/6J ±  kb
transcript ENSMUST00000006828 Ensembl | MGI Sequence Detail 2391 Not Applicable  
polypeptide ENSMUSP00000006828 Ensembl | MGI Sequence Detail 654 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    196 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR008155 Amyloidogenic glycoprotein
    IPR011178 Amyloidogenic glycoprotein, copper-binding
    IPR024329 Amyloidogenic glycoprotein, E2 domain
    IPR008154 Amyloidogenic glycoprotein, extracellular
    IPR019744 Amyloidogenic glycoprotein, extracellular domain conserved site
    IPR015849 Amyloidogenic glycoprotein, heparin-binding
    IPR019745 Amyloidogenic glycoprotein, intracellular domain, conserved site
    IPR019543 Beta-amyloid precursor protein C-terminal
Molecular
Reagents
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  • All nucleic 88
    Genomic 1
    cDNA 85
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1360
References
more
  • Summaries
    All 46
    Developmental Gene Expression 11
    Gene Ontology 12
    Phenotypes 11
  • Earliest
    J:3302 Wasco W, et al., Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. Proc Natl Acad Sci U S A. 1992 Nov 15;89(22):10758-62
  • Latest
    J:224563 Vnencak M, et al., Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus. J Comp Neurol. 2015 Aug 1;523(11):1717-29

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory