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Apeh Gene Detail
Summary
  • Symbol
    Apeh
  • Name
    acylpeptide hydrolase
  • Synonyms
    MGC:38101, N-acylaminoacyl peptide hydrolase
  • Feature Type
    protein coding gene
  • IDs
    MGI:88041
    NCBI Gene: 235606
  • Gene Overview
    MyGene.info: APEH
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108085414-108094554 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 59.07 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88041
protein coding gene Chr9:108085413-108094606 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035286
protein coding gene Chr9:110014469-110023603 (-)
A/J MGP_AJ_G0035265
protein coding gene Chr9:105990886-105999961 (-)
AKR/J MGP_AKRJ_G0035197
protein coding gene Chr9:108635708-108644783 (-)
BALB/cJ MGP_BALBcJ_G0035259
protein coding gene Chr9:105687662-105696737 (-)
C3H/HeJ MGP_C3HHeJ_G0034969
protein coding gene Chr9:109034173-109043248 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035779
protein coding gene Chr9:112994394-113003469 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032677
protein coding gene Chr9:103425611-103434750 (-)
CAST/EiJ MGP_CASTEiJ_G0034280
protein coding gene Chr9:108990938-109000046 (-)
CBA/J MGP_CBAJ_G0034937
protein coding gene Chr9:116984253-116993333 (-)
DBA/2J MGP_DBA2J_G0035098
protein coding gene Chr9:105446310-105455385 (-)
FVB/NJ MGP_FVBNJ_G0035046
protein coding gene Chr9:104215395-104224470 (-)
LP/J MGP_LPJ_G0035174
protein coding gene Chr9:110202913-110212047 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035085
protein coding gene Chr9:118579357-118588487 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035800
protein coding gene Chr9:108918096-108927225 (-)
PWK/PhJ MGP_PWKPhJ_G0033987
protein coding gene Chr9:105767701-105776841 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033822
protein coding gene Chr9:108974444-108984681 (-)
WSB/EiJ MGP_WSBEiJ_G0034401
protein coding gene Chr9:108793933-108803013 (-)



Homology
more
  • Human Ortholog
    APEH, acylaminoacyl-peptide hydrolase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    APEH, acylaminoacyl-peptide hydrolase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AARE, ACPH, APH, D3F15S2, D3S48E, DNF15S2, OPH
  • Links
    NCBI Gene ID: 327
    neXtProt AC: NX_P13798
    UniProt: P13798

  • Chr Location
    3p21.31; chr3:49673102-49683508 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    6 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 235606 NCBI Gene Model | MGI Sequence Detail 9141 C57BL/6J ±  kb
transcript NM_146226 RefSeq | MGI Sequence Detail 2407 C57BL/6  
polypeptide Q8R146 UniProt | EBI | MGI Sequence Detail 732 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • EC
  • InterPro Domains
    IPR029058 Alpha/Beta hydrolase fold
    IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
    IPR002471 Peptidase S9, serine active site
    IPR011042 Six-bladed beta-propeller, TolB-like
Molecular
Reagents
less
  • All nucleic 121
    Genomic 3
    cDNA 118

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1351
References
more
  • Summaries
    All 28
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:11449 Degen SJ, et al., Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development. Biochemistry. 1991 Oct 8;30(40):9781-91
  • Latest
    J:212432 Santhoshkumar P, et al., Lens crystallin modifications and cataract in transgenic mice overexpressing acylpeptide hydrolase. J Biol Chem. 2014 Mar 28;289(13):9039-52

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory