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Prdx3
Gene Detail
Symbol

Name
ID
Prdx3
peroxiredoxin 3
MGI:88034
Synonyms
Aop1, D0Tohi1, Ef2l, Mer5, Prx III, SP22, TDXM
Feature Type
protein coding gene
Genetic Map
Chromosome 19
56.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr19:60864051-60874556 bp, - strand
From VEGA annotation of GRCm38

  10506 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4944  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRDX3
Protein SuperFamily: AHPC
Gene Tree: Prdx3

Human
homologs
PRDX3, peroxiredoxin 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10935
neXtProt AC: NX_P30048

Human Synonyms: AOP1, AOP-1, HBC189, MER5, PRO1748, prx-III, SP-22

Human Chr (Location): 10q25-q26; chr10:119167699-119178865 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(16) Targeted(2)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for a gene-trapped allele exhibit decreased body weight, and increased susceptibility to LPS-induced lung inflammation and oxidative damage.
 
Interactions
Prdx3 interacts with 96 markers (Mir10a, Mir16-1, Mir16-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (180)    Tissues (146)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 132
Western blot 2
RT-PCR 46
cDNA source data(163)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prdx3 ; ZFIN prdx3    NEW 
Molecular
reagents
All nucleic(166) Genomic(1) cDNA(163) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021212 (Evidence)
Ensembl Gene Model ENSMUSG00000024997 (Evidence)
Entrez Gene 11757 (Evidence)
UniGene 29821
DFCI TC1574037, TC1689258
DoTS DT.55107790
NIA Mouse Gene Index U039209
EC 1.11.1.15
Consensus CDS Project CCDS29944.1
International Mouse Phenotyping Consortium Status Prdx3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021212 VEGA Gene Model | MGI Sequence Detail 10506 C57BL/6J ±  kb
transcript OTTMUST00000050247 VEGA | MGI Sequence Detail 1478 Not Applicable 
polypeptide OTTMUSP00000023435 VEGA | MGI Sequence Detail 257 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(107 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
InterPro IPR019479 Peroxiredoxin, C-terminal
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000013193 thioredoxin-dependent peroxide reductase, mitochondrial
References
(Earliest) J:10114 Yamamoto T, et al., Cloning of a housekeeping-type gene (MER5) preferentially expressed in murine erythroleukemia cells. Gene. 1989 Aug 15;80(2):337-43
(Latest) J:172853 Kohr MJ, et al., Characterization of potential S-nitrosylation sites in the myocardium. Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1327-35
All references(56)
Other
accession IDs
MGD-MRK-1339, MGD-MRK-2429, MGD-MRK-9312, MGI:2147761

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory