About   Help   FAQ
Prdx3 Gene Detail
Summary
  • Symbol
    Prdx3
  • Name
    peroxiredoxin 3
  • Synonyms
    Aop1, D0Tohi1, Ef2l, Mer5, Prx III, SP22, TDXM
  • Feature Type
    protein coding gene
  • IDs
    MGI:88034
    NCBI Gene: 11757
  • Gene Overview
    MyGene.info: PRDX3
Location & Maps
more
  • Sequence Map
    Chr19:60864051-60874556 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10506 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PRDX3, peroxiredoxin 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRDX3, peroxiredoxin 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AOP1, AOP-1, HBC189, MER5, PRO1748, prx-III, SP-22
  • Links
    NCBI Gene ID: 10935
    neXtProt AC: NX_P30048

  • Chr Location
    10q25-q26; chr10:119167699-119178865 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 4944
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: PRDX3
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Gene trapped
    16
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for a gene-trapped allele exhibit decreased body weight, and increased susceptibility to LPS-induced lung inflammation and oxidative damage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021212 VEGA Gene Model | MGI Sequence Detail 10506 C57BL/6J ±  kb
transcript OTTMUST00000050247 VEGA | MGI Sequence Detail 1478 Not Applicable  
polypeptide OTTMUSP00000023435 VEGA | MGI Sequence Detail 257 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    103 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013193 thioredoxin-dependent peroxide reductase, mitochondrial
  • EC
  • InterPro Domains
    IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
    IPR019479 Peroxiredoxin, C-terminal
    IPR012336 Thioredoxin-like fold
Molecular
Reagents
less
  • All nucleic 166
    Genomic 1
    cDNA 163
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1339, MGD-MRK-2429, MGD-MRK-9312, MGI:2147761
References
more
  • Summaries
    All 56
    Developmental Gene Expression 5
    Gene Ontology 13
    Phenotypes 9
  • Earliest
    J:10114 Yamamoto T, et al., Cloning of a housekeeping-type gene (MER5) preferentially expressed in murine erythroleukemia cells. Gene. 1989 Aug 15;80(2):337-43
  • Latest
    J:227089 Pirson M, et al., Expression of peroxiredoxins and thioredoxins in the mouse spinal cord during embryonic development. J Comp Neurol. 2015 Dec 1;523(17):2599-617

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/19/2016
MGI 6.03
The Jackson Laboratory