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Anxa7 Gene Detail
Summary
  • Symbol
    Anxa7
  • Name
    annexin A7
  • Synonyms
    Anx7, synexin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88031
    NCBI Gene: 11750
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20505344-20530009 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 11.53 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    651 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88031
 protein coding gene Chr14:20505328-20530201 (-)
129S1/SvImJ ENSMUSG00200014461
 protein coding gene Chr14:12290783-12309038 (-)
A/J ENSMUSG00195020637
 protein coding gene Chr14:13377881-13395953 (-)
AKR/J ENSMUSG00220025356
 protein coding gene Chr14:12508397-12526467 (-)
BALB/cJ ENSMUSG00180038820
 protein coding gene Chr14:12472799-12490868 (-)
C3H/HeJ ENSMUSG00175020550
 protein coding gene Chr14:12533783-12551853 (-)
C57BL/6NJ ENSMUSG00215024361
 protein coding gene Chr14:12723393-12741464 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018989
 protein coding gene Chr14:13216703-13243681 (-)
CAST/EiJ ENSTCUG00005029432
 protein coding gene Chr14:12648465-12666575 (-)
CBA/J ENSMUSG00210026013
 protein coding gene Chr14:12763881-12782136 (-)
DBA/2J ENSMUSG00185036757
 protein coding gene Chr14:17048962-17067216 (-)
FVB/NJ ENSMUSG00205019942
 protein coding gene Chr14:12605891-12624146 (-)
JF1/MsJ ENSUMUG00000042511
 protein coding gene Chr14:24263367-24281414 (-)
LP/J ENSMUSG00230037026
 protein coding gene Chr14:24330742-24348997 (-)
NOD/ShiLtJ ENSMUSG00190036837
 protein coding gene Chr14:12762808-12781062 (-)
NZO/HlLtJ ENSMUSG00225035398
 protein coding gene Chr14:18559797-18577808 (-)
PWK/PhJ ENSLUMG00010020069
 protein coding gene Chr14:834566-861136 (-)
SPRET/EiJ ENSMSPG00010026529
 protein coding gene Chr14:14385503-14412494 (-)
WSB/EiJ ENSIUOG00005031649
 protein coding gene Chr14:12580431-12598689 (-)



Homology
more
  • Human Ortholog
    ANXA7, annexin A7
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANXA7, annexin A7
  • Synonyms
    ANX7, SNX, SYNEXIN
  • Links
    NCBI Gene ID: 310
    UniProt: P20073

  • Chr Location
    10q22.2; chr10:73375101-73414731 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    3 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele are viable but exhibit altered Ca2+ signaling and/or homeostasis in cardiomyocytes and glia cells, and changes in erythrocyte shape, osmotic resistance, platelet number and aggregation velocity. Homozygotes for another null allele die at ~E10 with cerebral hemorrhage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    53
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    645
  • Tissues
    33
  • cDNA Data
    29
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11750 NCBI Gene Model | MGI Sequence Detail 24666 C57BL/6J ±  kb
    transcript NM_001374757 RefSeq | MGI Sequence Detail 2824 ZRU/MplStud  
    polypeptide Q07076 UniProt | EBI | MGI Sequence Detail 463 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 6
      cDNA 33
      Primer pair 1
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-1336, MGI:2145610, MGI:2145612
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 1
      Gene Ontology 14
      Phenotypes 18
    • Earliest
      J:19395 Magendzo K, et al., Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain. J Biol Chem. 1991 Feb 15;266(5):3228-32
    • Latest
      J:362596 Manke MC, et al., ANXA7 Regulates Platelet Lipid Metabolism and Ca(2+) Release in Arterial Thrombosis. Circ Res. 2021 Aug 6;129(4):494-507
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory