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Anxa7 Gene Detail
Summary
  • Symbol
    Anxa7
  • Name
    annexin A7
  • Synonyms
    Anx7, synexin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88031
    NCBI Gene: 11750
  • Gene Overview
    MyGene.info: ANXA7
Location & Maps
more
  • Sequence Map
    Chr14:20455261-20480133 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24873 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 11.53 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    ANXA7, annexin A7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ANXA7, annexin A7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ANX7, SNX, SYNEXIN
  • Links
    NCBI Gene ID: 310
    neXtProt AC: NX_P20073

  • Chr Location
    10q22.2; chr10:73375431-73414083 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 3 genetic backgrounds
    3 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Gene trapped
    25
  • Targeted
    2
  • Incidental Mutations
Homozygotes for a null allele are viable but exhibit altered Ca2+ signaling and/or homeostasis in cardiomyocytes and glia cells, and changes in erythrocyte shape, osmotic resistance, platelet number and aggregation velocity. Homozygotes for another null allele die at ~E10 with cerebral hemorrhage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11750 NCBI Gene Model | MGI Sequence Detail 24873 C57BL/6J ±  kb
transcript NM_009674 RefSeq | MGI Sequence Detail 2965 C57BL/6  
polypeptide Q07076 UniProt | EBI | MGI Sequence Detail 463 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    87 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 37
    Genomic 5
    cDNA 31
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-1336, MGI:2145610, MGI:2145612
References
more
  • Summaries
    All 46
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:19395 Magendzo K, et al., Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain. J Biol Chem. 1991 Feb 15;266(5):3228-32
  • Latest
    J:218578 Voelkl J, et al., Annexin A7 deficiency potentiates cardiac NFAT activity promoting hypertrophic signaling. Biochem Biophys Res Commun. 2014 Feb 28;445(1):244-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory