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Anxa7 Gene Detail
Summary
  • Symbol
    Anxa7
  • Name
    annexin A7
  • Synonyms
    Anx7, synexin
  • Feature Type
    protein coding gene
  • IDs
    MGI:88031
    NCBI Gene: 11750
  • Gene Overview
    MyGene.info: ANXA7
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:20455261-20480133 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 11.53 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    87 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88031
protein coding gene Chr14:20455260-20480133 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021036
protein coding gene Chr14:13214534-13240809 (-)
A/J MGP_AJ_G0020985
protein coding gene Chr14:12909178-12933675 (-)
AKR/J MGP_AKRJ_G0020962
protein coding gene Chr14:13431293-13455668 (-)
BALB/cJ MGP_BALBcJ_G0020988
protein coding gene Chr14:13012806-13037182 (-)
C3H/HeJ MGP_C3HHeJ_G0020772
protein coding gene Chr14:13369144-13394421 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021421
protein coding gene Chr14:13709932-13735320 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018989
protein coding gene Chr14:13216703-13243681 (-)
CAST/EiJ MGP_CASTEiJ_G0020296
protein coding gene Chr14:13127498-13155172 (-)
CBA/J MGP_CBAJ_G0020738
protein coding gene Chr14:14398489-14435559 (-)
DBA/2J MGP_DBA2J_G0020861
protein coding gene Chr14:12734641-12759500 (-)
FVB/NJ MGP_FVBNJ_G0020844
protein coding gene Chr14:12629022-12653593 (-)
LP/J MGP_LPJ_G0020937
protein coding gene Chr14:13436338-13462451 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020870
protein coding gene Chr14:14180171-14205833 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021454
protein coding gene Chr14:13220051-13245818 (-)
PWK/PhJ MGP_PWKPhJ_G0020045
protein coding gene Chr14:12296827-12321496 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019867
protein coding gene Chr14:12999212-13026438 (-)
WSB/EiJ MGP_WSBEiJ_G0020352
protein coding gene Chr14:13199564-13224975 (-)



Homology
more
  • Human Ortholog
    ANXA7, annexin A7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ANXA7, annexin A7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ANX7, SNX, SYNEXIN
  • Links
    NCBI Gene ID: 310
    neXtProt AC: NX_P20073
    UniProt: P20073

  • Chr Location
    10q22.2; chr10:73375101-73414085 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 2 alleles in 3 genetic backgrounds
    3 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a null allele are viable but exhibit altered Ca2+ signaling and/or homeostasis in cardiomyocytes and glia cells, and changes in erythrocyte shape, osmotic resistance, platelet number and aggregation velocity. Homozygotes for another null allele die at ~E10 with cerebral hemorrhage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11750 NCBI Gene Model | MGI Sequence Detail 24873 C57BL/6J ±  kb
transcript NM_009674 RefSeq | MGI Sequence Detail 2965 C57BL/6  
polypeptide Q07076 UniProt | EBI | MGI Sequence Detail 463 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 39
    Genomic 6
    cDNA 32
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-1336, MGI:2145610, MGI:2145612
References
more
  • Summaries
    All 51
    Developmental Gene Expression 1
    Gene Ontology 11
    Phenotypes 12
  • Earliest
    J:19395 Magendzo K, et al., Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain. J Biol Chem. 1991 Feb 15;266(5):3228-32
  • Latest
    J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory