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Anxa4 Gene Detail
Summary
  • Symbol
    Anxa4
  • Name
    annexin A4
  • Synonyms
    AIV, annexin IV, Anx4, Xanx-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:88030
    NCBI Gene: 11746
  • Gene Overview
    MyGene.info: ANXA4
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:86736840-86793584 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.75 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    608 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88030
protein coding gene Chr6:86736840-86793593 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030983
protein coding gene Chr6:88047777-88113968 (-)
A/J MGP_AJ_G0030949
protein coding gene Chr6:84643367-84699159 (-)
AKR/J MGP_AKRJ_G0030880
protein coding gene Chr6:87092875-87159779 (-)
BALB/cJ MGP_BALBcJ_G0030962
protein coding gene Chr6:84654852-84713963 (-)
C3H/HeJ MGP_C3HHeJ_G0030748
protein coding gene Chr6:97308968-97373207 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031419
protein coding gene Chr6:90428235-90493166 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028603
protein coding gene Chr6:82833987-82885394 (-)
CAST/EiJ MGP_CASTEiJ_G0030071
protein coding gene Chr6:87163236-87226405 (-)
CBA/J MGP_CBAJ_G0030646
protein coding gene Chr6:93986617-94059440 (-)
DBA/2J MGP_DBA2J_G0030802
protein coding gene Chr6:83961620-84018709 (-)
FVB/NJ MGP_FVBNJ_G0030755
protein coding gene Chr6:83146528-83203520 (-)
LP/J MGP_LPJ_G0030879
protein coding gene Chr6:88078337-88139285 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030788
protein coding gene Chr6:98099579-98162830 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031446
protein coding gene Chr6:86933563-86994190 (-)
PWK/PhJ MGP_PWKPhJ_G0029786
protein coding gene Chr6:82906026-82971996 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029614
protein coding gene Chr6:85773034-85830697 (-)
WSB/EiJ MGP_WSBEiJ_G0030152
protein coding gene Chr6:87396943-87457514 (-)



Homology
more
  • Human Ortholog
    ANXA4, annexin A4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ANXA4, annexin A4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ANX4, HEL-S-274, P32.5, PAP-II, PIG28, PP4-X, ZAP36
  • Links
    NCBI Gene ID: 307
    neXtProt AC: NX_P09525
    UniProt: P09525

  • Chr Location
    2p13.3; chr2:69643805-69826477 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68164
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ANXA4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele often display abnormal maternal nurturing behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029994 Ensembl Gene Model | MGI Sequence Detail 56745 C57BL/6J ±  kb
transcript ENSMUST00000113675 Ensembl | MGI Sequence Detail 2030 Not Applicable  
polypeptide ENSMUSP00000109305 Ensembl | MGI Sequence Detail 319 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 104
    cDNA 104

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-1335, MGI:2141386, MGI:2141642
References
more
  • Summaries
    All 46
    Developmental Gene Expression 10
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:12689 Tait JF, et al., Chromosomal mapping of the human annexin IV (ANX4) gene. Genomics. 1992 Feb;12(2):313-8
  • Latest
    J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory