Ank1
Gene Detail

Symbol Name ID

Ank1 ankyrin 1, erythroid MGI:88024

Synonyms

Ank-1, pale

Feature Type

protein coding gene

Genetic Map

Chromosome 8

11.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr8:22974844-23150497 bp, + strand From VEGA annotation of GRCm38   175654 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55427  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ank1

Human homologs

Human Homolog		ANK1, ankyrin 1, erythrocytic
NCBI Gene ID		286
neXtProt AC		NX_P16157
Human Synonyms		ANK, SPH1, SPH2
Human Chr (Location)		8p11.1; chr8:41510744-41754280 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ANK1

Alleles and phenotypes

All alleles(7) : Targeted(2) Spontaneous(2) Chemically induced(3)
 

Homozygous mutant animals are anemic, infertile, and have reduced body size. Mutant animals also exhibit jaundice, bone marrow hyperplasia, splenomegaly, hepatomegaly, enlarged lymph nodes, increased white blood cell count, and cardiac hypertrophy.

 
Human Diseases Modeled Using Mouse Ank1 (2)    Alleles Annotated to Human Diseases(4)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	ER to Golgi vesicle-mediated transport, erythrocyte development, ...
Component	A band, axolemma, ...
Function	ATPase binding, cytoskeletal adaptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (33)    Tissues (30)    Images (8)
Theiler Stages: 17, 19, 21, 23, 28

Assay Type	Results
RNA in situ	29
RT-PCR	2
RNase protection	2

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(2) cDNA(20) Primer pair(1) Other(1)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000026381 (Evidence)
Ensembl Gene Model	ENSMUSG00000031543 (Evidence)
Entrez Gene	11733 (Evidence)
DFCI	TC1576228, TC1582131, TC1588437, TC1622029, TC1670415
DoTS	DT.101161410, DT.110867054, DT.110867066, DT.110867074, DT.527812, DT.87038850, DT.87051370, DT.91337468, DT.94188023, DT.94188024, DT.94188026
NIA Mouse Gene Index	U009178
Consensus CDS Project	CCDS22187.1, CCDS52523.1
International Mouse Knockout Project Status	Ank1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026381	VEGA Gene Model | MGI Sequence Detail	175654	C57BL/6J
transcript	OTTMUST00000065236	VEGA | MGI Sequence Detail	8218	Not Applicable
polypeptide	OTTMUSP00000032484	VEGA | MGI Sequence Detail	1907	Not Applicable

All sequences(135) RefSeq(16) UniProt(14)

Polymorphisms

RFLP(3) : SNPs(155 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015663	Ankyrin-1
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR000488	Death
InterPro	IPR011029	DEATH-like
InterPro	IPR000906	ZU5
Protein Ontology	PR:000004033	ankyrin-1

References

(Earliest) J:5247 Landaw SA, Kinetic aspects of endogenous carbon monoxide production in experimental animals. Ann N Y Acad Sci. 1970 Oct 5;174(1):32-48
(Latest) J:187820 Greth A, et al., A novel ENU-mutation in ankyrin-1 disrupts malaria parasite maturation in red blood cells of mice. PLoS One. 2012;7(6):e38999
All references(80)

Other accession IDs

MGD-MRK-12782, MGD-MRK-1324, MGD-MRK-1327, MGI:3832665