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Ang
Gene Detail
Symbol

Name
ID
Ang
angiogenin, ribonuclease, RNase A family, 5
MGI:88022
Synonyms
Ang1, Rnase5a
Feature Type
protein coding gene
Genetic Map
Chromosome 14
26.37 cM, cytoband B-C1
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr14:51091077-51102007 bp, + strand
From Ensembl annotation of GRCm38

  10931 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74385  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee

HCOP human homology predictions: ANG
Protein SuperFamily: pyrimidine-specific ribonuclease/angiogenin
Gene Tree: Ang

Human
homologs
ANG, angiogenin, ribonuclease, RNase A family, 5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 283
neXtProt AC: NX_P03950

Human Synonyms: ALS9, HEL168, RAA1, RNASE4, RNASE5

Human Chr (Location): 14q11.1-q11.2; chr14:20684177-20694186 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ANG

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
Interactions
Ang interacts with 23 markers (Mir25, Mir33, Mir135a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process activation of phospholipase A2 activity, activation of phospholipase C activity, ...
Component angiogenin-PRI complex, basal lamina, ...
Function actin binding, copper ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (5)    Tissues (1)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(2) cDNA(5) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000072115 (Evidence)
Entrez Gene 11727 (Evidence)
DFCI TC1584620
DoTS DT.489938
EC 3.1.27.-
PDB 2BWK, 2BWL
Consensus CDS Project CCDS27034.1
International Mouse Phenotyping Consortium Status Ang
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000072115 Ensembl Gene Model | MGI Sequence Detail 10931 C57BL/6J ±  kb
transcript ENSMUST00000171688 Ensembl | MGI Sequence Detail 799 Not Applicable 
polypeptide ENSMUSP00000132084 Ensembl | MGI Sequence Detail 145 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(230 from dbSNP Build 137)    SNPs within 2kb including multiple locations(250)
Protein-related
information
ResourceIDDescription
InterPro IPR001427 Ribonuclease A
InterPro IPR023411 Ribonuclease A, active site
InterPro IPR023412 Ribonuclease A-domain
Protein Ontology PR:000004020 angiogenin
References
(Earliest) J:10791 Bond MD, et al., Isolation and sequencing of mouse angiogenin DNA. Biochem Biophys Res Commun. 1990 Sep 28;171(3):988-95
(Latest) J:208392 Iyer S, et al., Crystal structures of murine angiogenin-2 and -3-probing 'structure--function' relationships amongst angiogenin homologues. FEBS J. 2013 Jan;280(1):302-18
All references(51)
Other
accession IDs
MGD-MRK-1320, MGI:2145626

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory