Ang
Gene Detail

Symbol Name ID

Ang angiogenin, ribonuclease, RNase A family, 5 MGI:88022

Synonyms

Ang1, Rnase5a

Feature Type

protein coding gene

Genetic Map

Chromosome 14

26.37 cM, cytoband B-C1
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr14:51091077-51102007 bp, + strand From Ensembl annotation of GRCm38   10931 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74385  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 3 cattle

Protein SuperFamily: pyrimidine-specific ribonuclease/angiogenin
Gene Tree: Ang

Human homologs

Human Homolog		ANG, angiogenin, ribonuclease, RNase A family, 5
NCBI Gene ID		283
neXtProt AC		NX_P03950
Human Synonyms		ALS9, HEL168, RNASE4, RNASE5
Human Chr (Location)		14q11.1-q11.2; chr14:21152336-21162345 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ANG

Alleles and phenotypes

All alleles(1) : Targeted(1)

Gene Ontology (GO) classifications

All GO classifications: (41 annotations)

Process	activation of phospholipase A2 activity, activation of phospholipase C activity, ...
Component	angiogenin-PRI complex, basal lamina, ...
Function	actin binding, copper ion binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (5)    Tissues (1)    Images (5)
Theiler Stages: 23

Assay Type	Results
RNA in situ	5

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(8) Genomic(2) cDNA(5) Primer pair(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000072115 (Evidence)
Entrez Gene	11727 (Evidence)
DFCI	TC1584620
DoTS	DT.489938
EC	3.1.27.-
PDB	2BWK, 2BWL
Consensus CDS Project	CCDS27034.1
International Mouse Knockout Project Status	Ang

Sequences

Length	Strain/Species
genomic	ENSMUSG00000072115	Ensembl Gene Model | MGI Sequence Detail	10931	C57BL/6J
transcript	ENSMUST00000069011	Ensembl | MGI Sequence Detail	1096	Not Applicable
polypeptide	ENSMUSP00000067434	Ensembl | MGI Sequence Detail	145	Not Applicable

All sequences(22) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(74 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001427	Ribonuclease A
InterPro	IPR023411	Ribonuclease A, active site
InterPro	IPR023412	Ribonuclease A-domain
Protein Ontology	PR:000004020	angiogenin

References

(Earliest) J:10791 Bond MD, et al., Isolation and sequencing of mouse angiogenin DNA. Biochem Biophys Res Commun. 1990 Sep 28;171(3):988-95
(Latest) J:184456 Skorupa A, et al., Motoneurons secrete angiogenin to induce RNA cleavage in astroglia. J Neurosci. 2012 Apr 11;32(15):5024-38
All references(50)

Other accession IDs

MGD-MRK-1320, MGI:2145626