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Ang
Gene Detail
 Symbol
Name
ID
Ang
angiogenin, ribonuclease, RNase A family, 5
MGI:88022
Synonyms Ang1, Rnase5a
Feature Type protein coding gene
Genetic Map
Chromosome 14
26.37 cM, cytoband B-C1
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr14:51091077-51102007 bp, + strand
From Ensembl annotation of GRCm38

  10931 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74385  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee

Protein SuperFamily: pyrimidine-specific ribonuclease/angiogenin
Gene Tree: Ang

Human
homologs
Human Homolog ANG, angiogenin, ribonuclease, RNase A family, 5
NCBI Gene ID 283
neXtProt AC  NX_P03950
Human Synonyms  ALS9, HEL168, RAA1, RNASE4, RNASE5
Human Chr (Location)  14q11.1-q11.2; chr14:20684177-20694186 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ANG
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from APF )
Interactions
Ang interacts with 23 markers (Mir25, Mir33, Mir135a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process activation of phospholipase A2 activity, activation of phospholipase C activity, ...
Component angiogenin-PRI complex, basal lamina, ...
Function actin binding, copper ion binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (5)    Tissues (1)    Images (5)
Theiler Stages: 23
Assay TypeResults
RNA in situ 5
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) Genomic(2) cDNA(5) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000072115 (Evidence)
Entrez Gene11727 (Evidence)
DFCITC1584620
DoTSDT.489938
EC3.1.27.-
PDB2BWK, 2BWL
Consensus CDS ProjectCCDS27034.1
International Mouse Knockout Project StatusAng
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000072115 Ensembl Gene Model | MGI Sequence Detail 10931 C57BL/6J ±  kb
transcript ENSMUST00000171688 Ensembl | MGI Sequence Detail 799 Not Applicable 
polypeptide ENSMUSP00000132084 Ensembl | MGI Sequence Detail 145 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(230 from dbSNP Build 137)    SNPs within 2kb including multiple locations(250)
Protein-related
information
ResourceIDDescription
InterPro IPR001427 Ribonuclease A
InterPro IPR023411 Ribonuclease A, active site
InterPro IPR023412 Ribonuclease A-domain
Protein Ontology PR:000004020 angiogenin
References (Earliest) J:10791 Bond MD, et al., Isolation and sequencing of mouse angiogenin DNA. Biochem Biophys Res Commun. 1990 Sep 28;171(3):988-95
(Latest) J:197903 Wang G, et al., Angiotensin II slow-pressor hypertension enhances NMDA currents and NOX2-dependent superoxide production in hypothalamic paraventricular neurons. Am J Physiol Regul Integr Comp Physiol. 2013 Jun;304(12):R1096-106
All references(52)
Other
accession IDs
MGD-MRK-1320, MGI:2145626

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory