Amy1 MGI Mouse Gene Detail - MGI:88019

Symbol

Amy1
Name

amylase 1, salivary
Synonyms

Amy-1

Feature Type

protein coding gene
IDs

MGI:88019
NCBI Gene: 11722
Member of

Amy cluster
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr3:113349601-113371399 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 49.35 cM
Mapping Data

66 experiments

SNPs within 2kb

630 from dbSNP Build 142
Strain Annotations

19
PCR

2
RFLP

9

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88019	protein coding gene	Chr3:113349359-113400348 (-)
129S1/SvImJ	ENSMUSG00200035500	protein coding gene	Chr3:109967387-110018548 (-)
A/J	ENSMUSG00195024534	protein coding gene	Chr3:110279386-110330548 (-)
AKR/J	ENSMUSG00220029115	protein coding gene	Chr3:108673186-108724335 (-)
BALB/cJ	ENSMUSG00180017093	protein coding gene	Chr3:110224138-110275293 (-)
C3H/HeJ	ENSMUSG00175028580	protein coding gene	Chr3:109764373-109815524 (-)
C57BL/6NJ	ENSMUSG00215020180	protein coding gene	Chr3:110472751-110523888 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025554	protein coding gene	Chr3:107442977-107494439 (-)
CAST/EiJ	ENSTCUG00005024477	protein coding gene	Chr3:110773264-110825595 (-)
CBA/J	ENSMUSG00210008300	protein coding gene	Chr3:110373736-110424893 (-)
DBA/2J	ENSMUSG00185021225	protein coding gene	Chr3:110963641-111014795 (-)
FVB/NJ	ENSMUSG00205020580	protein coding gene	Chr3:109426396-109477549 (-)
JF1/MsJ	ENSUMUG00000004852	protein coding gene	Chr3:109789270-109847590 (-)
LP/J	ENSMUSG00230011033	protein coding gene	Chr3:112862912-112914072 (-)
NOD/ShiLtJ	ENSMUSG00190024481	protein coding gene	Chr3:111252904-111305519 (-)
NZO/HlLtJ	ENSMUSG00225002891	protein coding gene	Chr3:115386134-115437284 (-)
PWK/PhJ	ENSLUMG00010022147	protein coding gene	Chr3:109688525-109739685 (-)
SPRET/EiJ	ENSMSPG00010030416	protein coding gene	Chr3:110315786-110366620 (-)
WSB/EiJ	ENSIUOG00005004445	protein coding gene	Chr3:110403298-110454449 (-)

Human Ortholog

AMY1A, amylase alpha 1A

Vertebrate Orthologs

9

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AMY1A, amylase alpha 1A
Synonyms

AMY1
Links

HGNC:474

NCBI Gene ID: 276

UniProt: P0DUB6
Chr Location

1p21.1; chr1:103650592-103664629 (+) GRCh38

Human Ortholog

AMY1B, amylase alpha 1B
Synonyms

AMY1
Links

HGNC:475

NCBI Gene ID: 277

UniProt: P0DTE7
Chr Location

1p21.1; chr1:103687415-103701064 (-) GRCh38

Human Ortholog

AMY1C, amylase alpha 1C
Synonyms

AMY1
Links

HGNC:476

NCBI Gene ID: 278

UniProt: P0DTE8
Chr Location

1p21.1; chr1:103745126-103758726 (+) GRCh38

Human Ortholog

AMY2A, amylase alpha 2A
Synonyms

AMY2, PA
Links

HGNC:477

NCBI Gene ID: 279

UniProt: P04746
Chr Location

1p21.1; chr1:103616651-103625780 (+) GRCh38

Human Ortholog

AMY2B, amylase alpha 2B
Synonyms

AMY2, AMY3, HXA
Links

HGNC:478

NCBI Gene ID: 280

UniProt: P19961
Chr Location

1p21.1; chr1:103553815-103579534 (+) GRCh38

MGI Vertebrate Homology

Amy1 stringent orthology
5 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: AMY1A, AMY1B, AMY1C, AMY2A, AMY2B
Gene Tree

Amy1

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References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 2 alleles in 3 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

3
Transgenic

2
Genomic Mutations

2 involving Amy1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

32
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

769
Tissues

110
cDNA Data

320
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AMY2A

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All Sequences

49
RefSeq

4
UniProt

4
CCDS

CCDS17776.1

Ensembl

ENSMUSG00000074264 (Evidence)
NCBI Gene

11722

			Length	Strain/Species	Flank
genomic	11722	NCBI Gene Model \| MGI Sequence Detail	21799	C57BL/6J	± kb
transcript	NM_007446	RefSeq \| MGI Sequence Detail	1797	ZRU/MplStud
polypeptide	P00687	UniProt \| EBI \| MGI Sequence Detail	511	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000037015 alpha-amylase 1

(term hierarchy)
EC

3.2.1.1
InterPro Domains

IPR006046 Alpha amylase

IPR006048 Alpha-amylase/branching enzyme, C-terminal all beta

IPR031319 Alpha-amylase, C-terminal domain

IPR017853 Glycoside hydrolase superfamily

IPR013780 Glycosyl hydrolase, all-beta

IPR006047 Glycosyl hydrolase family 13, catalytic domain
GlyGen

P00687 1 site, 1 O-linked glycan (1 site)

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All nucleic 332

Genomic 6

cDNA 320

Primer pair 4

Other 2

Microarray probesets 3

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MGD-MRK-1313, MGD-MRK-1315

Summaries

All 144

Developmental Gene Expression 11

Diseases 1

Gene Ontology 11

Phenotypes 21
Earliest

J:12977 Sick K, et al., Genetics of amylase isozymes in the mouse. Hereditas. 1964;51:291-296
Latest

J:340404 Bohuslavova R, et al., NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development. Nat Commun. 2023 Sep 9;14(1):5554

TSS for Amy1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr35260	Chr3:113371392-113371405 (-)	0 bp
Tssr35259	Chr3:113371382-113371389 (-)	13 bp
Tssr35258	Chr3:113368439-113368451 (-)	2,954 bp
Tssr35257	Chr3:113368407-113368423 (-)	2,984 bp
Tssr35256	Chr3:113368353-113368362 (-)	3,041 bp
Tssr35255	Chr3:113368290-113368301 (-)	3,103 bp
Tssr35254	Chr3:113367891-113367918 (-)	3,494 bp
Tssr35253	Chr3:113367866-113367874 (-)	3,529 bp
Tssr35252	Chr3:113358660-113358671 (-)	12,733 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24