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Mat1a Gene Detail
Summary
  • Symbol
    Mat1a
  • Name
    methionine adenosyltransferase I, alpha
  • Synonyms
    AdoMet, Ams, MAT, MATA1, SAMS, SAMS1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88017
    NCBI Gene: 11720
  • Gene Overview
    MyGene.info: MAT1A
Location & Maps
more
  • Sequence Map
    Chr14:41105381-41124412 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19032 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 22.36 cM, cytoband C1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAT1A, methionine adenosyltransferase 1A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAT1A, methionine adenosyltransferase 1A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAT, MATA1, SAMS, SAMS1
  • Links
    NCBI Gene ID: 4143
    neXtProt AC: NX_Q00266

  • Chr Location
    10q22; chr10:80271820-80289979 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Mat1a mouse models; 1 with human MAT1A associations

Human Disease Mouse Models
       Methionine Adenosyltransferase Deficiency   OMIM: 250850 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    2 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have significantly elevated levels of methionine in the circulation and develop liver steatosis with age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037798 Ensembl Gene Model | MGI Sequence Detail 19032 C57BL/6J ±  kb
transcript ENSMUST00000047286 Ensembl | MGI Sequence Detail 3208 Not Applicable  
polypeptide ENSMUSP00000044288 Ensembl | MGI Sequence Detail 396 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    112 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000010201 S-adenosylmethionine synthetase isoform type-1
  • EC
  • InterPro Domains
    IPR002133 S-adenosylmethionine synthetase
    IPR022629 S-adenosylmethionine synthetase, central domain
    IPR022631 S-adenosylmethionine synthetase, conserved site
    IPR022630 S-adenosylmethionine synthetase, C-terminal
    IPR022628 S-adenosylmethionine synthetase, N-terminal
    IPR022636 S-adenosylmethionine synthetase superfamily
Molecular
Reagents
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  • All nucleic 15
    Genomic 2
    cDNA 12
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1311, MGI:2145596
References
more
  • Summaries
    All 38
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:12854 Sakata SF, et al., Cloning and expression of murine S-adenosylmethionine synthetase. J Biol Chem. 1993 Jul 5;268(19):13978-86
  • Latest
    J:194986 Mavila N, et al., Fibroblast growth factor receptor-mediated activation of AKT-beta-catenin-CBP pathway regulates survival and proliferation of murine hepatoblasts and hepatic tumor initiating stem cells. PLoS One. 2012;7(11):e50401

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory