Mat1a
Gene Detail

Symbol Name ID

Mat1a methionine adenosyltransferase I, alpha MGI:88017

Synonyms

AdoMet, Ams, MAT, MATA1, SAMS, SAMS1

Feature Type

protein coding gene

Genetic Map

Chromosome 14

22.36 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:41105381-41124412 bp, + strand From NCBI annotation of GRCm38   19032 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68057  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: methionine adenosyltransferase
Gene Tree: Mat1a

Human homologs

Human Homolog		MAT1A, methionine adenosyltransferase I, alpha
NCBI Gene ID		4143
neXtProt AC		NX_Q00266
Human Synonyms		MAT, MATA1, SAMS, SAMS1
Human Chr (Location)		10q22; chr10:82031576-82049434 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MAT1A

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruptions in this gene have significantly elevated levels of methionine in the circulation and develop liver steatosis with age.

 
Human Diseases Modeled Using Mouse Mat1a (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	metabolic process, one-carbon metabolic process, ...
Component	cytosol, nuclear matrix
Function	ADP binding, amino acid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (101)    Tissues (97)    Images (4)
Theiler Stages: 22, 24, 26

Assay Type	Results
RNA in situ	95
RT-PCR	6

cDNA source data(187)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(190) Genomic(2) cDNA(187) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000037798 (Evidence)
Entrez Gene	11720 (Evidence)
UniGene	14064
DFCI	TC1574304
DoTS	DT.537038, DT.97375140
NIA Mouse Gene Index	U015516
EC	2.5.1.6
Consensus CDS Project	CCDS26959.1
International Mouse Knockout Project Status	Mat1a

Sequences

Length	Strain/Species
genomic	11720	NCBI Gene Model | MGI Sequence Detail	19032	C57BL/6J
transcript	NM_133653	RefSeq | MGI Sequence Detail	3486	C57BL/6
polypeptide	Q91X83	UniProt | EBI | MGI Sequence Detail	396	Not Applicable

All sequences(22) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(100 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002133	S-adenosylmethionine synthetase
InterPro	IPR022629	S-adenosylmethionine synthetase, central domain
InterPro	IPR022631	S-adenosylmethionine synthetase, conserved site
InterPro	IPR022630	S-adenosylmethionine synthetase, C-terminal
InterPro	IPR022628	S-adenosylmethionine synthetase, N-terminal
InterPro	IPR022636	S-adenosylmethionine synthetase superfamily
Protein Ontology	PR:000010201	S-adenosylmethionine synthetase isoform type-1

Graphical View of Protein Domain Structure

References

(Earliest) J:12854 Sakata SF, et al., Cloning and expression of murine S-adenosylmethionine synthetase. J Biol Chem. 1993 Jul 5;268(19):13978-86
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)

Other accession IDs

MGD-MRK-1311, MGI:2145596