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Mat1a Gene Detail
Summary
  • Symbol
    Mat1a
  • Name
    methionine adenosyltransferase I, alpha
  • Synonyms
    AdoMet, Ams, MAT, MATA1, SAMS, SAMS1
  • Feature Type
    protein coding gene
  • IDs
    MGI:88017
    NCBI Gene: 11720
  • Gene Overview
    MyGene.info: MAT1A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:41105035-41124412 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19378 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 22.36 cM, cytoband C1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAT1A, methionine adenosyltransferase 1A
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAT1A, methionine adenosyltransferase 1A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAT, MATA1, SAMS, SAMS1
  • Links
    NCBI Gene ID: 4143
    neXtProt AC: NX_Q00266
    UniProt: Q00266

  • Chr Location
    10q22.3; chr10:80271820-80290003 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    2 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have significantly elevated levels of methionine in the circulation and develop liver steatosis with age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037798 Ensembl Gene Model | MGI Sequence Detail 19378 C57BL/6J ±  kb
    transcript ENSMUST00000225720 Ensembl | MGI Sequence Detail 3468 Not Applicable  
    polypeptide ENSMUSP00000153488 Ensembl | MGI Sequence Detail 396 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      112 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000010201 S-adenosylmethionine synthetase isoform type-1
    • EC
    • InterPro Domains
      IPR002133 S-adenosylmethionine synthetase
      IPR022629 S-adenosylmethionine synthetase, central domain
      IPR022631 S-adenosylmethionine synthetase, conserved site
      IPR022630 S-adenosylmethionine synthetase, C-terminal
      IPR022628 S-adenosylmethionine synthetase, N-terminal
      IPR022636 S-adenosylmethionine synthetase superfamily
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 12
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1311, MGI:2145596
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:12854 Sakata SF, et al., Cloning and expression of murine S-adenosylmethionine synthetase. J Biol Chem. 1993 Jul 5;268(19):13978-86
    • Latest
      J:194986 Mavila N, et al., Fibroblast growth factor receptor-mediated activation of AKT-beta-catenin-CBP pathway regulates survival and proliferation of murine hepatoblasts and hepatic tumor initiating stem cells. PLoS One. 2012;7(11):e50401

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory