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Mat1a
Gene Detail
Symbol

Name
ID
Mat1a
methionine adenosyltransferase I, alpha
MGI:88017
Synonyms
AdoMet, Ams, MAT, MATA1, SAMS, SAMS1
Feature Type
protein coding gene
Genetic Map
Chromosome 14
22.36 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:41105381-41124412 bp, + strand
From Ensembl annotation of GRCm38

  19032 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68057  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAT1A
Protein SuperFamily: methionine adenosyltransferase
Gene Tree: Mat1a

Human
homologs
MAT1A, methionine adenosyltransferase I, alpha
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4143
neXtProt AC: NX_Q00266

Human Synonyms: MAT, MATA1, SAMS, SAMS1

Human Chr (Location): 10q22; chr10:80271820-80289979 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MAT1A

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene have significantly elevated levels of methionine in the circulation and develop liver steatosis with age.
 
Human Diseases Modeled in Mice Using Mat1a (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Mat1a interacts with 207 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process one-carbon metabolic process, protein homooligomerization, ...
Component cytosol, nuclear matrix
Function ADP binding, amino acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (101)    Tissues (97)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 95
RT-PCR 6
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mat1a ; ZFIN mat1a    NEW 
Molecular
reagents
All nucleic(15) Genomic(2) cDNA(12) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000037798 (Evidence)
Entrez Gene 11720 (Evidence)
DFCI TC1574304
DoTS DT.537038, DT.97375140
NIA Mouse Gene Index U015516
EC 2.5.1.6
Consensus CDS Project CCDS26959.1
International Mouse Phenotyping Consortium Status Mat1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037798 Ensembl Gene Model | MGI Sequence Detail 19032 C57BL/6J ±  kb
transcript ENSMUST00000047286 Ensembl | MGI Sequence Detail 3208 Not Applicable 
polypeptide ENSMUSP00000044288 Ensembl | MGI Sequence Detail 396 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(111 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002133 S-adenosylmethionine synthetase
InterPro IPR022629 S-adenosylmethionine synthetase, central domain
InterPro IPR022631 S-adenosylmethionine synthetase, conserved site
InterPro IPR022630 S-adenosylmethionine synthetase, C-terminal
InterPro IPR022628 S-adenosylmethionine synthetase, N-terminal
InterPro IPR022636 S-adenosylmethionine synthetase superfamily
Protein Ontology PR:000010201 S-adenosylmethionine synthetase isoform type-1
References
(Earliest) J:12854 Sakata SF, et al., Cloning and expression of murine S-adenosylmethionine synthetase. J Biol Chem. 1993 Jul 5;268(19):13978-86
(Latest) J:194986 Mavila N, et al., Fibroblast growth factor receptor-mediated activation of AKT-beta-catenin-CBP pathway regulates survival and proliferation of murine hepatoblasts and hepatic tumor initiating stem cells. PLoS One. 2012;7(11):e50401
All references(40)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1311, MGI:2145596

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory