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Amd1
Gene Detail
Symbol

Name
ID
Amd1
S-adenosylmethionine decarboxylase 1
MGI:88004
Synonyms
AdoMetDC, Amd-1, SAMDC
Feature Type
protein coding gene
Genetic Map
Chromosome 10
21.85 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:40287458-40302188 bp, - strand
From NCBI annotation of GRCm38

  14731 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1235  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: S-adenosylmethionine decarboxylase, eukaryotic type
Gene Tree: Amd1

Human
homologs
Human Homolog AMD1, adenosylmethionine decarboxylase 1
NCBI Gene ID 262
neXtProt AC  NX_P17707
Human Synonyms  ADOMETDC, AMD, SAMDC
Human Chr (Location)  6q21; chr6:110814621-110895713 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(5) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality before somite formation and embryonic growth arrest.
 
Interactions
Amd1 interacts with 302 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process in utero embryonic development, polyamine biosynthetic process, ...
Component cytosol
Function adenosylmethionine decarboxylase activity, carboxy-lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (264)    Tissues (120)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 255
RT-PCR 9
cDNA source data(161)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(165) Genomic(2) cDNA(162) Primer pair(1)
Microarray probesets(10)
Other database
links
Ensembl Gene ModelENSMUSG00000075232 (Evidence)
Entrez Gene11702 (Evidence)
UniGene253533
EC4.1.1.50
Consensus CDS ProjectCCDS48544.1
International Mouse Knockout Project StatusAmd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11702 NCBI Gene Model | MGI Sequence Detail 14731 C57BL/6J ±  kb
transcript NM_009665 RefSeq | MGI Sequence Detail 3206 C57BL/6 
polypeptide P0DMN7 UniProt | EBI | MGI Sequence Detail 334 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(30 from dbSNP Build 137)    SNPs within 2kb including multiple locations(64)
Protein-related
information
ResourceIDDescription
InterPro IPR001985 S-adenosylmethionine decarboxylase
InterPro IPR018166 S-adenosylmethionine decarboxylase, conserved site
InterPro IPR016067 S-adenosylmethionine decarboxylase, core
InterPro IPR018167 S-adenosylmethionine decarboxylase subgroup
Protein Ontology PR:000035207 S-adenosylmethionine decarboxylase proenzyme 1
Graphical View of Protein Domain Structure
References
(Earliest) J:748 Janne OA, et al., Androgen-regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase genes. J Steroid Biochem Mol Biol. 1991;40(1-3):307-15
(Latest) J:181615 Zhang D, et al., AMD1 is essential for ESC self-renewal and is translationally down-regulated on differentiation to neural precursor cells. Genes Dev. 2012 Mar 1;26(5):461-73
All references(37)
Other
accession IDs
MGD-MRK-1293, MGD-MRK-1294

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory