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Ambp Gene Detail
Summary
  • Symbol
    Ambp
  • Name
    alpha 1 microglobulin/bikunin
  • Synonyms
    ASPI, HI-30, Intin4, Itil, ulinastatin, Urinary Trypsin Inhibitor, UTI
  • Feature Type
    protein coding gene
  • IDs
    MGI:88002
    NCBI Gene: 11699
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:63143275-63154799 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11525 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 33.96 cM, cytoband C1-C3
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    AMBP, alpha-1-microglobulin/bikunin precursor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AMBP, alpha-1-microglobulin/bikunin precursor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A1M, EDC1, HCP, HI30, IATIL, ITI, ITIL, ITILC, UTI
  • Links
    NCBI Gene ID: 259
    neXtProt AC: NX_P02760
    UniProt: P02760

  • Chr Location
    9q32; chr9:114060127-114078472 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 1 genetic background
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Female homozygotes for targeted null mutations exhibit reduced ovulation rates, oocytes lacking a zona pellucida, and a very low fertilization rate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000009032 VEGA Gene Model | MGI Sequence Detail 11525 C57BL/6J ±  kb
    transcript OTTMUST00000020486 VEGA | MGI Sequence Detail 1268 Not Applicable  
    polypeptide OTTMUSP00000009386 VEGA | MGI Sequence Detail 349 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      120 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 237
      cDNA 235
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11437, MGD-MRK-11503, MGD-MRK-1291, MGI:2140204
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:2174 Salier JP, et al., Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily. Genomics. 1992 Sep;14(1):83-8
    • Latest
      J:241506 Dwyer CA, et al., Neurodevelopmental Changes in Excitatory Synaptic Structure and Function in the Cerebral Cortex of Sanfilippo Syndrome IIIA Mice. Sci Rep. 2017 Apr 18;7:46576

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory