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Ambp Gene Detail
Summary
  • Symbol
    Ambp
  • Name
    alpha 1 microglobulin/bikunin
  • Synonyms
    ASPI, HI-30, Intin4, Itil, ulinastatin, Urinary Trypsin Inhibitor, UTI
  • Feature Type
    protein coding gene
  • IDs
    MGI:88002
    NCBI Gene: 11699
Location & Maps
more
  • Sequence Map
    Chr4:63143275-63154799 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11525 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    AMBP, alpha-1-microglobulin/bikunin precursor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AMBP, alpha-1-microglobulin/bikunin precursor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    A1M, EDC1, HCP, HI30, IATIL, ITI, ITIL, ITILC, UTI
  • Links
    NCBI Gene ID: 259
    neXtProt AC: NX_P02760

  • Chr Location
    9q32-q33; chr9:114060127-114078472 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 1 genetic background
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Female homozygotes for targeted null mutations exhibit reduced ovulation rates, oocytes lacking a zona pellucida, and a very low fertilization rate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009032 VEGA Gene Model | MGI Sequence Detail 11525 C57BL/6J ±  kb
transcript OTTMUST00000020486 VEGA | MGI Sequence Detail 1268 Not Applicable  
polypeptide OTTMUSP00000009386 VEGA | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    120 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 236
    cDNA 234
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11437, MGD-MRK-11503, MGD-MRK-1291, MGI:2140204
References
more
  • Summaries
    All 52
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:2174 Salier JP, et al., Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily. Genomics. 1992 Sep;14(1):83-8
  • Latest
    J:210558 McDonald B, et al., Kupffer cells and activation of endothelial TLR4 coordinate neutrophil adhesion within liver sinusoids during endotoxemia. Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(11):G797-806

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory