Aldob MGI Mouse Gene Detail - MGI:87995 - aldolase B, fructose-bisphosphate

Aldob Gene Detail

Symbol

Aldob
Name

aldolase B, fructose-bisphosphate
Synonyms

Aldo2, Aldo-2

Feature Type

protein coding gene
IDs

MGI:87995
NCBI Gene: 230163
Gene Overview

MyGene.info: ALDOB

Sequence Map

Chr4:49535995-49549546 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

13552 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 26.57 cM
Mapping Data

3 experiments

Human Ortholog

ALDOB, aldolase, fructose-bisphosphate B

Vertebrate Orthologs

10

Human Ortholog

ALDOB, aldolase, fructose-bisphosphate B
Orthology source: HomoloGene, HGNC
Synonyms

ALDB, ALDO2
Links

HGNC:417

NCBI Gene ID: 229

neXtProt AC: NX_P05062
Chr Location

9q21.3-q22.2; chr9:101420560-101435780 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 20060
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: ALDOB
Protein SuperFamily

fructose-bisphosphate aldolase
Gene Tree

Aldob

Diseases

1 with Aldob mouse models; 1 with human ALDOB associations

Human Disease

Mouse Models

Fructose Intolerance, Hereditary OMIM: 229600

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Targeted

4
Incidental Mutations

Mutagenetix , APF

Following exposure to a 40% fructose diet, mice homozygous for a null allele exhibit failure to thrive, liver pathology and dysfunction, and a high mortality rate.

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All GO Annotations

38
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

204
Tissues

155
cDNA Data

934
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

GEISHA ALDOB

Xenbase aldob

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Aldob interacts with 157 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

44
RefSeq

2
UniProt

3
CCDS

CCDS18176.1
UniGene

482116

			Length	Strain/Species	Flank
genomic	OTTMUSG00000008318	VEGA Gene Model \| MGI Sequence Detail	13552	C57BL/6J	± kb
transcript	OTTMUST00000018935	VEGA \| MGI Sequence Detail	2016	Not Applicable
polypeptide	OTTMUSP00000008705	VEGA \| MGI Sequence Detail	364	Not Applicable

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SNPs within 2kb

122 from dbSNP Build 142

RFLP

1

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UniProt

3 Sequences
Protein Ontology

PR:000003935 fructose-bisphosphate aldolase B
EC

4.1.2.13
InterPro Domains

IPR013785 Aldolase-type TIM barrel

IPR000741 Fructose-bisphosphate aldolase, class-I

IPR029768 Fructose-bisphosphate aldolase class-I active site

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All nucleic 937

Genomic 2

cDNA 934

Primer pair 1

Microarray probesets 4

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MGD-MRK-1277, MGD-MRK-1279, MGI:2387622

Summaries

All 44

Developmental Gene Expression 6

Diseases 1

Gene Ontology 7

Phenotypes 7
Earliest

J:35647 Stoltzner G, Effects of life-long dietary protein restriction on mortality, growth, organ weights, blood counts, liver aldolase and kidney catalase in Balb/C mice. Growth. 1977 Dec;41(4):337-48
Latest

J:220330 Oppelt SA, et al., Aldolase-B knockout in mice phenocopies hereditary fructose intolerance in humans. Mol Genet Metab. 2015 Mar;114(3):445-50

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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