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Aldob Gene Detail
Summary
  • Symbol
    Aldob
  • Name
    aldolase B, fructose-bisphosphate
  • Synonyms
    Aldo2, Aldo-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:87995
    NCBI Gene: 230163
Location & Maps
more
  • Sequence Map
    Chr4:49535995-49549546 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13552 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ALDOB, aldolase, fructose-bisphosphate B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ALDOB, aldolase, fructose-bisphosphate B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ALDB, ALDO2
  • Links
    NCBI Gene ID: 229
    neXtProt AC: NX_P05062

  • Chr Location
    9q21.3-q22.2; chr9:101420560-101435780 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Aldob mouse models; 1 with human ALDOB associations

Human Disease Mouse Models
       Fructose Intolerance, Hereditary   OMIM: 229600 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Following exposure to a 40% fructose diet, mice homozygous for a null allele exhibit failure to thrive, liver pathology and dysfunction, and a high mortality rate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008318 VEGA Gene Model | MGI Sequence Detail 13552 C57BL/6J ±  kb
transcript OTTMUST00000018935 VEGA | MGI Sequence Detail 2016 Not Applicable  
polypeptide OTTMUSP00000008705 VEGA | MGI Sequence Detail 364 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    122 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000003935 fructose-bisphosphate aldolase B
  • EC
  • InterPro Domains
    IPR013785 Aldolase-type TIM barrel
    IPR000741 Fructose-bisphosphate aldolase, class-I
    IPR029768 Fructose-bisphosphate aldolase class-I active site
Molecular
Reagents
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  • All nucleic 937
    Genomic 2
    cDNA 934
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1277, MGD-MRK-1279, MGI:2387622
References
more
  • Summaries
    All 43
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:35647 Stoltzner G, Effects of life-long dietary protein restriction on mortality, growth, organ weights, blood counts, liver aldolase and kidney catalase in Balb/C mice. Growth. 1977 Dec;41(4):337-48
  • Latest
    J:220330 Oppelt SA, et al., Aldolase-B knockout in mice phenocopies hereditary fructose intolerance in humans. Mol Genet Metab. 2015 Mar;114(3):445-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory