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Aldob Gene Detail
Summary
  • Symbol
    Aldob
  • Name
    aldolase B, fructose-bisphosphate
  • Synonyms
    Aldo2, Aldo-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:87995
    NCBI Gene: 230163
  • Gene Overview
    MyGene.info: ALDOB
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr4:49535995-49549546 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      13552 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 26.57 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ALDOB, aldolase, fructose-bisphosphate B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ALDOB, aldolase, fructose-bisphosphate B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALDB, ALDO2
  • Links
    NCBI Gene ID: 229
    neXtProt AC: NX_P05062
    UniProt: P05062

  • Chr Location
    9q31.1; chr9:101420560-101435780 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human ALDOB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Following exposure to a 40% fructose diet, mice homozygous for a null allele exhibit failure to thrive, liver pathology and dysfunction, and a high mortality rate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    212
  • Tissues
    159
  • cDNA Data
    934
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000008318 VEGA Gene Model | MGI Sequence Detail 13552 C57BL/6J ±  kb
    transcript OTTMUST00000018935 VEGA | MGI Sequence Detail 2016 Not Applicable  
    polypeptide OTTMUSP00000008705 VEGA | MGI Sequence Detail 364 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      122 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 937
      Genomic 2
      cDNA 934
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1277, MGD-MRK-1279, MGI:2387622
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:35647 Stoltzner G, Effects of life-long dietary protein restriction on mortality, growth, organ weights, blood counts, liver aldolase and kidney catalase in Balb/C mice. Growth. 1977 Dec;41(4):337-48
    • Latest
      J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/09/2018
    MGI 6.12     		The Jackson Laboratory