About   Help   FAQ
Alas1
Gene Detail
Symbol

Name
ID
Alas1
aminolevulinic acid synthase 1
MGI:87989
Synonyms
5-aminolevulinate synthase, Alas-1, ALAS-N, succinyl-CoA: glycine C-succinyl transferase
Feature Type
protein coding gene
Genetic Map
Chromosome 9
57.46 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:106233455-106248126 bp, - strand
From VEGA annotation of GRCm38

  14672 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55478  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 5-aminolevulinate synthase
Gene Tree: Alas1

Human
homologs
Human Homolog ALAS1, 5'-aminolevulinate synthase 1
NCBI Gene ID 211
neXtProt AC  NX_P13196
Human Synonyms  ALAS, ALAS3, ALASH, MIG4
Human Chr (Location)  3p21.1; chr3:52198083-52214327 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(7) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele exhibit embryonic lethality.
 
Interactions
Alas1 interacts with 110 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process biosynthetic process, heme biosynthetic process, ...
Component cytoplasm, mitochondrial matrix, ...
Function 5-aminolevulinate synthase activity, catalytic activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (146)    Tissues (114)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 143
Northern blot 3
cDNA source data(211)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(217) Genomic(4) cDNA(211) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000033383 (Evidence)
Ensembl Gene ModelENSMUSG00000032786 (Evidence)
Entrez Gene11655 (Evidence)
UniGene290578
DFCITC1572694, TC1719177
DoTSDT.101296249, DT.101380583, DT.536186, DT.101227200
NIA Mouse Gene IndexU031289
EC2.3.1.37
Consensus CDS ProjectCCDS40756.2
International Mouse Knockout Project StatusAlas1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033383 VEGA Gene Model | MGI Sequence Detail 14672 C57BL/6J ±  kb
transcript OTTMUST00000083804 VEGA | MGI Sequence Detail 3089 Not Applicable 
polypeptide OTTMUSP00000045080 VEGA | MGI Sequence Detail 642 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(133 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015118 5-aminolevulinate synthase presequence
InterPro IPR004839 Aminotransferase, class I/classII
InterPro IPR001917 Aminotransferase, class-II, pyridoxal-phosphate binding site
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro IPR015422 Pyridoxal phosphate-dependent transferase, major region, subdomain 2
InterPro IPR010961 Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase
Protein Ontology PR:000003916 5-aminolevulinate synthase, nonspecific, mitochondrial
References
(Earliest) J:10017 Schoenhaut DS, et al., Structure of a mouse erythroid 5-aminolevulinate synthase gene and mapping of erythroid-specific DNAse I hypersensitive sites. Nucleic Acids Res. 1989 Sep 12;17(17):7013-28
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(44)
Other
accession IDs
MGD-MRK-1268, MGD-MRK-1270

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/09/2014
MGI 5.20
The Jackson Laboratory