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Akp3 Gene Detail
Summary
  • Symbol
    Akp3
  • Name
    alkaline phosphatase 3, intestine, not Mn requiring
  • Synonyms
    Akp-3, IAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:87984
    NCBI Gene: 11648
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:87125008-87127912 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 44.06 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87984
protein coding gene Chr1:87124973-87127912 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016256
protein coding gene Chr1:88459503-88462442 (+)
A/J MGP_AJ_G0016237
protein coding gene Chr1:85156833-85159772 (+)
AKR/J MGP_AKRJ_G0016198
protein coding gene Chr1:87670403-87673342 (+)
BALB/cJ MGP_BALBcJ_G0016194
protein coding gene Chr1:85277316-85280255 (+)
C3H/HeJ MGP_C3HHeJ_G0016022
protein coding gene Chr1:87932624-87935563 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016650
protein coding gene Chr1:91807480-91810419 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014372
protein coding gene Chr1:79611238-79614410 (+)
CAST/EiJ MGP_CASTEiJ_G0015607
protein coding gene Chr1:87135749-87140247 (+)
CBA/J MGP_CBAJ_G0015998
protein coding gene Chr1:94672952-94675891 (+)
DBA/2J MGP_DBA2J_G0016101
protein coding gene Chr1:84461238-84464177 (+)
FVB/NJ MGP_FVBNJ_G0016100
protein coding gene Chr1:83524039-83526978 (+)
LP/J MGP_LPJ_G0016172
protein coding gene Chr1:89526695-89534073 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016126
protein coding gene Chr1:97957052-97960026 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016693
protein coding gene Chr1:87772746-87775685 (+)
PWK/PhJ MGP_PWKPhJ_G0015394
protein coding gene Chr1:83758539-83761500 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015174
protein coding gene Chr1:86699607-86702551 (+)
WSB/EiJ MGP_WSBEiJ_G0015671
protein coding gene Chr1:87439497-87442424 (+)



Homology
more
  • Human Ortholog
    ALPG, alkaline phosphatase, germ cell
  • Vertebrate Orthologs
    12
  • Human Ortholog
    ALPG, alkaline phosphatase, germ cell
    Orthology source: HGNC
  • Synonyms
    ALPPL, ALPPL2, GCAP
  • Links
    NCBI Gene ID: 251
    neXtProt AC: NX_P10696
    UniProt: P10696

  • Chr Location
    2q37.1; chr2:232406842-232410714 (+)  GRCh38.p7

  • Human Ortholog
    ALPI, alkaline phosphatase, intestinal
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IAP
  • Links
    NCBI Gene ID: 248
    neXtProt AC: NX_P09923
    UniProt: P09923

  • Chr Location
    2q37.1; chr2:232456112-232460745 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene show no gross abnormalities in appearance, behavior or fertility. They do display accelerated lipid absorption on a high fat diet leading to elevated plasma triglycerides and increased weight gain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11648 NCBI Gene Model | MGI Sequence Detail 2905 C57BL/6J ±  kb
    transcript NM_007432 RefSeq | MGI Sequence Detail 1680 Not Specified  
    polypeptide P24822 UniProt | EBI | MGI Sequence Detail 559 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • EC
    • InterPro Domains
      IPR001952 Alkaline phosphatase
      IPR018299 Alkaline phosphatase, active site
      IPR017849 Alkaline phosphatase-like, alpha/beta/alpha
      IPR017850 Alkaline-phosphatase-like, core domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 3
      cDNA 7
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1250, MGD-MRK-1255
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 7
      Gene Ontology 4
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:240923 Chen S, et al., Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1432-E1440

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory