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Ak4 Gene Detail
Summary
  • Symbol
    Ak4
  • Name
    adenylate kinase 4
  • Synonyms
    Ak-3, Ak3l1, Ak-4, D4Ertd274e
  • Feature Type
    protein coding gene
  • IDs
    MGI:87979
    NCBI Gene: 11639
  • Gene Overview
    MyGene.info: AK4
Location & Maps
more
  • Sequence Map
    Chr4:101419277-101466995 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47719 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 46.84 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    AK4, adenylate kinase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AK4, adenylate kinase 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AK3, AK3L1, AK3L2, AK 4
  • Links
    NCBI Gene ID: 205
    neXtProt AC: NX_P27144

  • Chr Location
    1p31.3; chr1:65147549-65232145 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    2
  • Gene trapped
    7
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Ak4
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008456 VEGA Gene Model | MGI Sequence Detail 47719 C57BL/6J ±  kb
transcript OTTMUST00000019192 VEGA | MGI Sequence Detail 4186 Not Applicable  
polypeptide OTTMUSP00000008800 VEGA | MGI Sequence Detail 223 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    425 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000029117 adenylate kinase isoenzyme 4, mitochondrial
  • EC
  • InterPro Domains
    IPR028586 Adenylate kinase 3/4, mitochondrial
    IPR028585 Adenylate kinase 4, mitochondrial
    IPR007862 Adenylate kinase, active site lid domain
    IPR006259 Adenylate kinase subfamily
    IPR000850 Adenylate kinase/UMP-CMP kinase
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 156
    Genomic 1
    cDNA 153
    Primer pair 2

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-1242, MGD-MRK-1243, MGD-MRK-1246, MGD-MRK-1247, MGI:1098752, MGI:87980
References
more
  • Summaries
    All 45
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:7470 Bonhomme F, et al., Biochemical diversity and evolution in the genus Mus. Biochem Genet. 1984 Apr;22(3-4):275-303
  • Latest
    J:183999 Ouseph MM, et al., Atypical E2F repressors and activators coordinate placental development. Dev Cell. 2012 Apr 17;22(4):849-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory