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Ak4 Gene Detail
Summary
  • Symbol
    Ak4
  • Name
    adenylate kinase 4
  • Synonyms
    Ak-3, Ak3l1, Ak-4, D4Ertd274e
  • Feature Type
    protein coding gene
  • IDs
    MGI:87979
    NCBI Gene: 11639
  • Gene Overview
    MyGene.info: AK4
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:101419277-101466995 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 46.84 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    425 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87979
protein coding gene Chr4:101418847-101467771 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028492
protein coding gene Chr4:101724083-101780932 (+)
A/J MGP_AJ_G0028455
protein coding gene Chr4:98166418-98214705 (+)
AKR/J MGP_AKRJ_G0028402
protein coding gene Chr4:100542223-100590306 (+)
BALB/cJ MGP_BALBcJ_G0028473
protein coding gene Chr4:98368435-98434130 (+)
C3H/HeJ MGP_C3HHeJ_G0028186
protein coding gene Chr4:101335272-101389661 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028912
protein coding gene Chr4:105568530-105622706 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026204
protein coding gene Chr4:93422458-93486587 (+)
CAST/EiJ MGP_CASTEiJ_G0027626
protein coding gene Chr4:99124420-99176333 (+)
CBA/J MGP_CBAJ_G0028155
protein coding gene Chr4:108885400-108942552 (+)
DBA/2J MGP_DBA2J_G0028305
protein coding gene Chr4:97861653-97913468 (+)
FVB/NJ MGP_FVBNJ_G0028272
protein coding gene Chr4:96701437-96750277 (+)
LP/J MGP_LPJ_G0028405
protein coding gene Chr4:102022124-102084969 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028300
protein coding gene Chr4:114432442-114487805 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028950
protein coding gene Chr4:100791858-100843751 (+)
PWK/PhJ MGP_PWKPhJ_G0027351
protein coding gene Chr4:96030251-96081176 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027173
protein coding gene Chr4:98242552-98299210 (+)
WSB/EiJ MGP_WSBEiJ_G0027704
protein coding gene Chr4:100956358-101012327 (+)



Homology
more
  • Human Ortholog
    AK4, adenylate kinase 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AK4, adenylate kinase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AK3, AK3L1, AK3L2, AK 4
  • Links
    NCBI Gene ID: 205
    neXtProt AC: NX_P27144
    UniProt: P27144

  • Chr Location
    1p31.3; chr1:65147342-65232145 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    13
  • Chemically induced (other)
    2
  • Gene trapped
    7
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    4 involving Ak4
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028527 Ensembl Gene Model | MGI Sequence Detail 47719 C57BL/6J ±  kb
transcript ENSMUST00000102780 Ensembl | MGI Sequence Detail 4186 Not Applicable  
polypeptide ENSMUSP00000099841 Ensembl | MGI Sequence Detail 223 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 157
    Genomic 1
    cDNA 154
    Primer pair 2

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-1242, MGD-MRK-1243, MGD-MRK-1246, MGD-MRK-1247, MGI:1098752, MGI:87980
References
more
  • Summaries
    All 51
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:7470 Bonhomme F, et al., Biochemical diversity and evolution in the genus Mus. Biochem Genet. 1984 Apr;22(3-4):275-303
  • Latest
    J:183999 Ouseph MM, et al., Atypical E2F repressors and activators coordinate placental development. Dev Cell. 2012 Apr 17;22(4):849-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory