Ak2 MGI Mouse Gene Detail - MGI:87978

Symbol

Ak2
Name

adenylate kinase 2
Synonyms

Ak-2, D4Ertd220e

Feature Type

protein coding gene
IDs

MGI:87978
NCBI Gene: 11637
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr4:128887017-128905322 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 62.62 cM
Mapping Data

5 experiments

SNPs within 2kb

136 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_87978	protein coding gene	Chr4:128885751-128905322 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028810	protein coding gene	Chr4:130844680-130864341 (+)
A/J	MGP_AJ_G0028769	protein coding gene	Chr4:125665519-125685086 (+)
AKR/J	MGP_AKRJ_G0028722	protein coding gene	Chr4:129141232-129160798 (+)
BALB/cJ	MGP_BALBcJ_G0028792	protein coding gene	Chr4:126247331-126266886 (+)
C3H/HeJ	MGP_C3HHeJ_G0028506	protein coding gene	Chr4:129197812-129218651 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029234	protein coding gene	Chr4:135802674-135822215 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026507	protein coding gene	Chr4:118797197-118816814 (+)
CAST/EiJ	MGP_CASTEiJ_G0027939	protein coding gene	Chr4:127364092-127385214 (+)
CBA/J	MGP_CBAJ_G0028472	protein coding gene	Chr4:139111055-139132637 (+)
DBA/2J	MGP_DBA2J_G0028621	protein coding gene	Chr4:126094915-126114520 (+)
FVB/NJ	MGP_FVBNJ_G0028588	protein coding gene	Chr4:124845970-124865783 (+)
LP/J	MGP_LPJ_G0028722	protein coding gene	Chr4:131154132-131173807 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028614	protein coding gene	Chr4:144016834-144036487 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029272	protein coding gene	Chr4:129509776-129531333 (+)
PWK/PhJ	MGP_PWKPhJ_G0027660	protein coding gene	Chr4:122664361-122684604 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027487	protein coding gene	Chr4:125369627-125392083 (+)
WSB/EiJ	MGP_WSBEiJ_G0028019	protein coding gene	Chr4:129620293-129644041 (+)

Human Ortholog

AK2, adenylate kinase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AK2, adenylate kinase 2
Synonyms

ADK2
Links

HGNC:362

NCBI Gene ID: 204

neXtProt AC: NX_P54819

UniProt: P54819
Chr Location

1p35.1; chr1:33007940-33036911 (-) GRCh38.p7

Alliance of Genome Resources

Ak2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AK2
Gene Tree

Ak2

Diseases

1 with human AK2 associations

				Human Disease	Mouse Models
				reticular dysgenesis IDs reticular dysgenesis DOID:0060020 DOID:1226 MESH:C538361 NCI:C27070 OMIM:267500 UMLS_CUI:C0272167

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

11
Radiation induced

1
Targeted

2
Genomic Mutations

4 involving Ak2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit embryonic lethality around E7.5 and show severely disrupted and disorganized mitochondria and cristae.

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All GO Annotations

28
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

980
Tissues

159
cDNA Data

239
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ak2

ZFIN ak2

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Ak2 interacts with 143 markers (Mir10a, Mir18, Mir27a, ...) View All

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All Sequences

54
RefSeq

5
UniProt

2
CCDS

CCDS18679.1, CCDS18680.1

Ensembl

ENSMUSG00000028792 (Evidence)
NCBI Gene

11637

			Length	Strain/Species	Flank
genomic	11637	NCBI Gene Model \| MGI Sequence Detail	18306	C57BL/6J	± kb
transcript	NR_138540	RefSeq \| MGI Sequence Detail	3354	C57BL/6
polypeptide	Q9WTP6	UniProt \| EBI \| MGI Sequence Detail	239	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003879 adenylate kinase 2, mitochondrial

(term hierarchy)
EC

2.7.4.3, 2.7.4.6
InterPro Domains

IPR028587 Adenylate kinase 2

IPR007862 Adenylate kinase, active site lid domain

IPR033690 Adenylate kinase, conserved site

IPR006259 Adenylate kinase subfamily

IPR000850 Adenylate kinase/UMP-CMP kinase

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 246

cDNA 241

Primer pair 5

Microarray probesets 4

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MGD-MRK-1241, MGD-MRK-1245, MGI:1098559

Summaries

All 57

Developmental Gene Expression 4

Gene Ontology 10

Phenotypes 16
Earliest

J:5872 Francke U, et al., Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Cytogenet Cell Genet. 1977;19(2-3):57-84
Latest

J:324982 Kim H, et al., AK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis. Cell Death Dis. 2022 May 18;13(5):469

TSS for Ak2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39092	Chr4:128887041-128887083 (+)	45 bp
Tssr39093	Chr4:128887085-128887127 (+)	89 bp
Tssr39094	Chr4:128901504-128901510 (+)	14,490 bp
Tssr1303	Chr4:128901887-128901900 (+)	14,877 bp
Tssr39095	Chr4:128902368-128902379 (+)	15,357 bp
Tssr39096	Chr4:128904489-128904501 (+)	17,478 bp
Tssr39097	Chr4:128904553-128904557 (+)	17,538 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 08/03/2022 MGI 6.21