About   Help   FAQ
Due to maintenance, access to MGI may be intermittent 8:00 AM ET Wed, September 18.
Ak2 Gene Detail
Summary
  • Symbol
    Ak2
  • Name
    adenylate kinase 2
  • Synonyms
    Ak-2, D4Ertd220e
  • Feature Type
    protein coding gene
  • IDs
    MGI:87978
    NCBI Gene: 11637
  • Gene Overview
    MyGene.info: AK2
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:128993224-129011529 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 62.62 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    307 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87978
 protein coding gene Chr4:128991958-129011529 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028810
 protein coding gene Chr4:130844680-130864341 (+)
A/J MGP_AJ_G0028769
 protein coding gene Chr4:125665519-125685086 (+)
AKR/J MGP_AKRJ_G0028722
 protein coding gene Chr4:129141232-129160798 (+)
BALB/cJ MGP_BALBcJ_G0028792
 protein coding gene Chr4:126247331-126266886 (+)
C3H/HeJ MGP_C3HHeJ_G0028506
 protein coding gene Chr4:129197812-129218651 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029234
 protein coding gene Chr4:135802674-135822215 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026507
 protein coding gene Chr4:118797197-118816814 (+)
CAST/EiJ MGP_CASTEiJ_G0027939
 protein coding gene Chr4:127364092-127385214 (+)
CBA/J MGP_CBAJ_G0028472
 protein coding gene Chr4:139111055-139132637 (+)
DBA/2J MGP_DBA2J_G0028621
 protein coding gene Chr4:126094915-126114520 (+)
FVB/NJ MGP_FVBNJ_G0028588
 protein coding gene Chr4:124845970-124865783 (+)
LP/J MGP_LPJ_G0028722
 protein coding gene Chr4:131154132-131173807 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028614
 protein coding gene Chr4:144016834-144036487 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029272
 protein coding gene Chr4:129509776-129531333 (+)
PWK/PhJ MGP_PWKPhJ_G0027660
 protein coding gene Chr4:122664361-122684604 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027487
 protein coding gene Chr4:125369627-125392083 (+)
WSB/EiJ MGP_WSBEiJ_G0028019
 protein coding gene Chr4:129620293-129644041 (+)



Homology
more
  • Human Ortholog
    AK2, adenylate kinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AK2, adenylate kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADK2
  • Links
    NCBI Gene ID: 204
    neXtProt AC: NX_P54819
    UniProt: P54819

  • Chr Location
    1p35.1; chr1:33007940-33036911 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human AK2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    308
  • Tissues
    159
  • cDNA Data
    239
  • Literature Summary
    4
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 11637 NCBI Gene Model | MGI Sequence Detail 18306 C57BL/6J ±  kb
transcript NR_138540 RefSeq | MGI Sequence Detail 3354 C57BL/6  
polypeptide Q9WTP6 UniProt | EBI | MGI Sequence Detail 239 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 246
    cDNA 241
    Primer pair 5

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1241, MGD-MRK-1245, MGI:1098559
References
more
  • Summaries
    All 51
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:5872 Francke U, et al., Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Cytogenet Cell Genet. 1977;19(2-3):57-84
  • Latest
    J:222992 Vadnais ML, et al., Adenine nucleotide metabolism and a role for AMP in modulating flagellar waveforms in mouse sperm. Biol Reprod. 2014 Jun;90(6):128
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
09/10/2019
MGI 6.14 		The Jackson Laboratory