Ak2 MGI Mouse Gene Detail - MGI:87978

Ak2 Gene Detail

Symbol

Ak2
Name

adenylate kinase 2
Synonyms

Ak-2, D4Ertd220e

Feature Type

protein coding gene
IDs

MGI:87978
NCBI Gene: 11637
Gene Overview

MyGene.info: AK2

Sequence Map

Chr4:128991958-129011529 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

19572 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 62.62 cM
Mapping Data

5 experiments

Human Ortholog

AK2, adenylate kinase 2

Vertebrate Orthologs

10

Human Ortholog

AK2, adenylate kinase 2
Orthology source: HomoloGene, HGNC
Synonyms

ADK2
Links

HGNC:362

NCBI Gene ID: 204

neXtProt AC: NX_P54819

UniProt: P54819
Chr Location

1p35.1; chr1:33007940-33036911 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 1227
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: AK2
Protein SuperFamily

adenylate kinase
Gene Tree

Ak2

Diseases

1 with human AK2 associations

				Human Disease	Mouse Models
				reticular dysgenesis IDs reticular dysgenesis DOID:0060020 DOID:1226 MESH:C538361 NCI:C27070 OMIM:267500 UMLS_CUI:C0272167

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

12 phenotype references

All Mutations and Alleles

16
Chemically induced (other)

2
Gene trapped

11
Radiation induced

1
Targeted

2
Genomic Mutations

4 involving Ak2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

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All GO Annotations

25
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

245
Tissues

155
cDNA Data

238
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ak2

ZFIN ak2

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Ak2 interacts with 143 markers (Mir10a, Mir18, Mir27a, ...) View All

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All Sequences

44
RefSeq

5
UniProt

2
CCDS

CCDS18679.1, CCDS18680.1
UniGene

29460

			Length	Strain/Species	Flank
genomic	OTTMUSG00000009623	VEGA Gene Model \| MGI Sequence Detail	19572	C57BL/6J	± kb
transcript	OTTMUST00000022144	VEGA \| MGI Sequence Detail	986	Not Applicable
polypeptide	OTTMUSP00000010094	VEGA \| MGI Sequence Detail	239	Not Applicable

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SNPs within 2kb

328 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000003879 adenylate kinase 2, mitochondrial

(term hierarchy)
EC

2.7.4.3
InterPro Domains

IPR028587 Adenylate kinase 2

IPR007862 Adenylate kinase, active site lid domain

IPR033690 Adenylate kinase, conserved site

IPR006259 Adenylate kinase subfamily

IPR000850 Adenylate kinase/UMP-CMP kinase

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 242

cDNA 240

Primer pair 2

Microarray probesets 4

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MGD-MRK-1241, MGD-MRK-1245, MGI:1098559

Summaries

All 49

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 12
Earliest

J:5872 Francke U, et al., Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Cytogenet Cell Genet. 1977;19(2-3):57-84
Latest

J:214478 Tanimura A, et al., Differential expression of adenine nucleotide converting enzymes in mitochondrial intermembrane space: a potential role of adenylate kinase isozyme 2 in neutrophil differentiation. PLoS One. 2014;9(2):e89916

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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