Ak2 Gene Detail

Summary

• Symbol
  Ak2
• Name
  adenylate kinase 2
• Synonyms
  Ak-2, D4Ertd220e

• Feature Type
  protein coding gene
• IDs
  MGI:87978
  NCBI Gene: 11637
• Gene Overview
  MyGene.info: AK2

Location & Maps

• Sequence Map
  Chr4:128991958-129011529 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    19572 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 4, 62.62 cM
• Mapping Data
  5 experiments

Homology

• Human Ortholog
  AK2, adenylate kinase 2

• Vertebrate Orthologs
  10

• Human Ortholog
  AK2, adenylate kinase 2
  Orthology source: HomoloGene, HGNC
• Synonyms
  ADK2
• Links
  HGNC:362

  NCBI Gene ID: 204

  neXtProt AC: NX_P54819

  
  
• Chr Location
  1p34; chr1:33007940-33036911 (-)  GRCh38.p2

---

• HomoloGene
  Vertebrate Homology Class 1227
  1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  
• HCOP
  human homology predictions: AK2
• Protein SuperFamily
  adenylate kinase
• Gene Tree
  Ak2
  

Human Diseases

• Diseases
  1 with human AK2 associations

				Human Disease	Mouse Models
				Reticular Dysgenesis   OMIM: 267500

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  12 phenotype references
  

• All Mutations and Alleles
  16
• Chemically induced (other)
  2
• Gene trapped
  11
• Radiation induced
  1
• Targeted
  2
• Genomic Mutations
  4 involving Ak2
• Incidental Mutations
  Mutagenetix , APF

Gene Ontology
(GO)
Classifications

• All GO Annotations
  25
• GO References
  8

• External Resources
  FuncBase

Expression

• Assay Results
  245
• Tissues
  155
• cDNA Data
  238
• Literature Summary
  4

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
• Other Vertebrate Links
  Xenbase ak2
  ZFIN ak2

Interactions

• Ak2 interacts with 143 markers (Mir10a, Mir18, Mir27a, ...) View All

Sequences &
Gene Models

• All Sequences
  44
• RefSeq
  5
• UniProt
  2
• CCDS
  CCDS18679.1, CCDS18680.1
• UniGene
  29460

• VEGA
  OTTMUSG00000009623 (Evidence)
• Ensembl
  ENSMUSG00000028792 (Evidence)
• NCBI Gene
  11637 (Evidence)

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000009623	VEGA Gene Model | MGI Sequence Detail	19572	C57BL/6J
transcript	OTTMUST00000022144	VEGA | MGI Sequence Detail	986	Not Applicable
polypeptide	OTTMUSP00000010094	VEGA | MGI Sequence Detail	239	Not Applicable

Polymorphisms

• SNPs within 2kb
  328 from dbSNP Build 142

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000003879 adenylate kinase 2, mitochondrial
• EC
  2.7.4.3
• InterPro Domains
  IPR028587 Adenylate kinase 2
  IPR007862 Adenylate kinase, active site lid domain
  IPR006259 Adenylate kinase subfamily
  IPR000850 Adenylate kinase/UMP-CMP kinase
  IPR027417 P-loop containing nucleoside triphosphate hydrolase

Molecular
Reagents

• All nucleic 242

  cDNA 240

  Primer pair 2

  
  

  Microarray probesets 4

Other
Accession IDs

MGD-MRK-1241, MGD-MRK-1245, MGI:1098559

References

• Summaries
  All 43

  Developmental Gene Expression 4

  Gene Ontology 8

  Phenotypes 12
• Earliest
  J:5872 Francke U, et al., Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Cytogenet Cell Genet. 1977;19(2-3):57-84
• Latest
  J:214478 Tanimura A, et al., Differential expression of adenine nucleotide converting enzymes in mitochondrial intermembrane space: a potential role of adenylate kinase isozyme 2 in neutrophil differentiation. PLoS One. 2014;9(2):e89916