Ak2
Gene Detail

Symbol Name ID

Ak2 adenylate kinase 2 MGI:87978

Synonyms

Ak-2, D4Ertd220e

Feature Type

protein coding gene

Genetic Map

Chromosome 4

62.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr4:128991958-129011529 bp, + strand From VEGA annotation of GRCm38   19572 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1227  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: adenylate kinase
Gene Tree: Ak2

Human homologs

Human Homolog		AK2, adenylate kinase 2
NCBI Gene ID		204
neXtProt AC		NX_P54819
Human Synonyms		ADK2, AK 2
Human Chr (Location)		1p34; chr1:33007940-33036911 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human AK2

Alleles and phenotypes

All alleles(12) : Gene trapped(11) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	ADP biosynthetic process, AMP metabolic process, ...
Component	cytosol, extracellular vesicular exosome, ...
Function	adenylate kinase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (245)    Tissues (155)    Images (41)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	199
RT-PCR	46

cDNA source data(238)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(242) cDNA(240) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000009623 (Evidence)
Ensembl Gene Model	ENSMUSG00000028792 (Evidence)
Entrez Gene	11637 (Evidence)
UniGene	29460
DFCI	TC1572081, TC1584870
DoTS	DT.101244545, DT.537175
NIA Mouse Gene Index	U004854
EC	2.7.4.3
Consensus CDS Project	CCDS18679.1, CCDS18680.1
International Mouse Knockout Project Status	Ak2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009623	VEGA Gene Model | MGI Sequence Detail	19572	C57BL/6J
transcript	OTTMUST00000022144	VEGA | MGI Sequence Detail	986	Not Applicable
polypeptide	OTTMUSP00000010094	VEGA | MGI Sequence Detail	239	Not Applicable

All sequences(48) RefSeq(5) UniProt(2)

Polymorphisms

SNPs within 2kb(327 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000850	Adenylate kinase
InterPro	IPR007862	Adenylate kinase, active site lid domain
InterPro	IPR006259	Adenylate kinase subfamily
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Protein Ontology	PR:000003879	adenylate kinase 2, mitochondrial

References

(Earliest) J:5872 Francke U, et al., Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Cytogenet Cell Genet. 1977;19(2-3):57-84
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(50)

Other accession IDs

MGD-MRK-1241, MGD-MRK-1245, MGI:1098559