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Ak1
Gene Detail
Symbol

Name
ID
Ak1
adenylate kinase 1
MGI:87977
Synonyms
Ak-1, B430205N08Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
22.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr2:32621758-32635058 bp, + strand
From VEGA annotation of GRCm38

  13301 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20135  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AK1
Protein SuperFamily: adenylate kinase
Gene Tree: Ak1

Human
homologs
AK1, adenylate kinase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 203
neXtProt AC: NX_P00568

Human Synonyms: HTL-S-58j

Human Chr (Location): 9q34.1; chr9:127866480-127877743 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human AK1

Mutations,
alleles, and
phenotypes
All mutations/alleles(41) : Gene trapped(39) Targeted(2)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit increased adenosine triphosphate (ATP) turnover and reduced efficiency of ATP utilization during muscle contraction.
 
Interactions
Ak1 interacts with 165 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process ADP biosynthetic process, AMP metabolic process, ...
Component cytoplasm, extracellular exosome, ...
Function adenylate kinase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (136)    Tissues (97)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 136
cDNA source data(77)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ak1 ; ZFIN ak1    NEW 
Molecular
reagents
All nucleic(79) cDNA(78) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000011984 (Evidence)
Ensembl Gene Model ENSMUSG00000026817 (Evidence)
Entrez Gene 11636 (Evidence)
UniGene 29189
DFCI TC1574279, TC1608410
DoTS DT.101230530, DT.101368474, DT.534696, DT.97336880, DT.99860046
NIA Mouse Gene Index U001626
EC 2.7.4.3, 2.7.4.6
Consensus CDS Project CCDS15924.1, CCDS57167.1
International Mouse Phenotyping Consortium Status Ak1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011984 VEGA Gene Model | MGI Sequence Detail 13301 C57BL/6J ±  kb
transcript OTTMUST00000028359 VEGA | MGI Sequence Detail 2034 Not Applicable 
polypeptide OTTMUSP00000012847 VEGA | MGI Sequence Detail 210 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(10) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR028582 Adenylate kinase isoenzyme 1
InterPro IPR006267 Adenylate kinase, isozyme 1/5
InterPro IPR000850 Adenylate kinase/UMP-CMP kinase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000003878 adenylate kinase isoenzyme 1
References
(Earliest) J:5872 Francke U, et al., Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Cytogenet Cell Genet. 1977;19(2-3):57-84
(Latest) J:197212 Kim HJ, et al., Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development. PLoS One. 2013;8(2):e55609
All references(67)
Other
accession IDs
MGD-MRK-1240, MGD-MRK-1244, MGI:2445070

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory