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Ak1 Gene Detail
Summary
  • Symbol
    Ak1
  • Name
    adenylate kinase 1
  • Synonyms
    Ak-1, B430205N08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:87977
    NCBI Gene: 11636
Location & Maps
more
  • Sequence Map
    Chr2:32621758-32635058 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13301 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 22.09 cM
  • Mapping Data
    14 experiments
Homology
more
  • Human Ortholog
    AK1, adenylate kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AK1, adenylate kinase 1
    Orthology source: HomoloGene
  • Synonyms
    HTL-S-58j
  • Links
    NCBI Gene ID: 203
    neXtProt AC: NX_P00568

  • Chr Location
    9q34.1; chr9:127866480-127877743 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human AK1 associations

Human Disease Mouse Models
       Adenylate Kinase Deficiency, Hemolytic Anemia Due to   OMIM: 612631
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    41
  • Gene trapped
    39
  • Targeted
    2
  • Incidental Mutations
    APF
Homozygotes for a targeted null mutation exhibit increased adenosine triphosphate (ATP) turnover and reduced efficiency of ATP utilization during muscle contraction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011984 VEGA Gene Model | MGI Sequence Detail 13301 C57BL/6J ±  kb
transcript OTTMUST00000028359 VEGA | MGI Sequence Detail 2034 Not Applicable  
polypeptide OTTMUSP00000012847 VEGA | MGI Sequence Detail 210 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    66 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 79
    cDNA 78
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-1240, MGD-MRK-1244, MGI:2445070
References
more
  • Summaries
    All 64
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 19
  • Earliest
    J:5872 Francke U, et al., Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Cytogenet Cell Genet. 1977;19(2-3):57-84
  • Latest
    J:197212 Kim HJ, et al., Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development. PLoS One. 2013;8(2):e55609

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory