Ak1
Gene Detail

Symbol Name ID

Ak1 adenylate kinase 1 MGI:87977

Synonyms

Ak-1, B430205N08Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 2

22.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr2:32621758-32646805 bp, + strand From VEGA annotation of GRCm38   25048 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20135  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: adenylate kinase
Gene Tree: Ak1

Human homologs

Human Homolog		AK1, adenylate kinase 1
NCBI Gene ID		203
neXtProt AC		NX_P00568
Human Chr (Location)		9q34.1; chr9:130628759-130640022 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human AK1

Alleles and phenotypes

All alleles(41) : Targeted(2) Gene trapped(39)
 

Homozygotes for a targeted null mutation exhibit increased adenosine triphosphate (ATP) turnover and reduced efficiency of ATP utilization during muscle contraction.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	ATP metabolic process, cell cycle arrest, ...
Component	cytoplasm, outer dense fiber, ...
Function	adenylate kinase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (136)    Tissues (97)    Images (29)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	136

cDNA source data(63)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(65) cDNA(64) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000011984 (Evidence)
Ensembl Gene Model	ENSMUSG00000026817 (Evidence)
Entrez Gene	11636 (Evidence)
UniGene	480325
DFCI	TC1574279, TC1608410
DoTS	DT.101230530, DT.101368474, DT.534696, DT.97336880, DT.99860046
NIA Mouse Gene Index	U001626
EC	2.7.4.3
Consensus CDS Project	CCDS15924.1, CCDS57167.1
International Mouse Knockout Project Status	Ak1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011984	VEGA Gene Model | MGI Sequence Detail	25048	C57BL/6J
transcript	OTTMUST00000028359	VEGA | MGI Sequence Detail	2034	Not Applicable
polypeptide	OTTMUSP00000012847	VEGA | MGI Sequence Detail	210	Not Applicable

All sequences(52) RefSeq(8) UniProt(1)

Polymorphisms

RFLP(2) : SNPs within 2kb(84 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000850	Adenylate kinase
InterPro	IPR006267	Adenylate kinase, isozyme 1
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Protein Ontology	PR:000003878	adenylate kinase isoenzyme 1

References

(Earliest) J:5872 Francke U, et al., Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Cytogenet Cell Genet. 1977;19(2-3):57-84
(Latest) J:187448 Yegutkin GG, et al., Metabolism of circulating ADP in the bloodstream is mediated via integrated actions of soluble adenylate kinase-1 and NTPDase1/CD39 activities. FASEB J. 2012 Sep;26(9):3875-83
All references(69)

Other accession IDs

MGD-MRK-1240, MGD-MRK-1244, MGI:2445070