Agtr1b
Gene Detail

Symbol Name ID

Agtr1b angiotensin II receptor, type 1b MGI:87965

Synonyms

Agtr-1b, Angtr-1b, AT1B

Feature Type

protein coding gene

Genetic Map

Chromosome 3

6.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr3:20314473-20367177 bp, - strand From VEGA annotation of GRCm38   52705 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:84871  Vertebrate Homology Class
1 mouse; 1 rat; 2 zebrafish

Protein SuperFamily: angiotensin II receptor
Gene Tree: Agtr1b

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygotes for targeted null mutations are phenotypically normal, but homozygotes for the Agtr1b/Agtr1a double knockout exhibit reductions in growth, survival, blood pressure, and kidney size not found in either single knockout.

 

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	blood vessel development, cellular response to dexamethasone stimulus, ...
Component	basolateral plasma membrane, integral to membrane, ...
Function	angiotensin type I receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (51)    Tissues (21)   
Theiler Stages: 24, 26, 28

Assay Type	Results
Northern blot	11
RT-PCR	40

cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(7) cDNA(4) Primer pair(3)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000034694 (Evidence)
Ensembl Gene Model	ENSMUSG00000054988 (Evidence)
Entrez Gene	11608 (Evidence)
UniGene	134863
DFCI	TC1593315
DoTS	DT.94167745
NIA Mouse Gene Index	U023870
Consensus CDS Project	CCDS17264.1
International Mouse Knockout Project Status	Agtr1b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034694	VEGA Gene Model | MGI Sequence Detail	52705	C57BL/6J
transcript	OTTMUST00000088104	VEGA | MGI Sequence Detail	2147	Not Applicable
polypeptide	OTTMUSP00000048002	VEGA | MGI Sequence Detail	359	Not Applicable

All sequences(21) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(164 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000248	Angiotensin II receptor
InterPro	IPR000190	AT1 angiotensin II receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001252	angiotensin II receptor 1B

References

(Earliest) J:1075 Sasamura H, et al., Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. Biochem Biophys Res Commun. 1992 May 29;185(1):253-9
(Latest) J:192277 Poduri A, et al., Regional variation in aortic AT1b receptor mRNA abundance is associated with contractility but unrelated to atherosclerosis and aortic aneurysms. PLoS One. 2012;7(10):e48462
All references(68)

Other accession IDs

MGD-MRK-1194, MGD-MRK-1196, MGD-MRK-1322