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Agtr1b
Gene Detail
 Symbol
Name
ID
Agtr1b
angiotensin II receptor, type 1b
MGI:87965
Synonyms Agtr-1b, Angtr-1b, AT1B
Feature Type protein coding gene
Genetic Map
Chromosome 3
6.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:20314473-20367177 bp, - strand
From VEGA annotation of GRCm38

  52705 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:84871  Vertebrate Homology Class
1 mouse; 1 rat; 2 zebrafish

Protein SuperFamily: angiotensin II receptor
Gene Tree: Agtr1b

Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations are phenotypically normal, but homozygotes for the Agtr1b/Agtr1a double knockout exhibit reductions in growth, survival, blood pressure, and kidney size not found in either single knockout.
 
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process blood vessel development, cellular response to dexamethasone stimulus, ...
Component basolateral plasma membrane, integral component of membrane, ...
Function angiotensin type II receptor activity, angiotensin type I receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (51)    Tissues (21)   
Theiler Stages: 24, 26, 28
Assay TypeResults
Northern blot 11
RT-PCR 40
cDNA source data(3)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) Genomic(7) cDNA(4) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000034694 (Evidence)
Ensembl Gene ModelENSMUSG00000054988 (Evidence)
Entrez Gene11608 (Evidence)
UniGene134863
DFCITC1593315
DoTSDT.94167745
NIA Mouse Gene IndexU023870
Consensus CDS ProjectCCDS17264.1
International Mouse Knockout Project StatusAgtr1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034694 VEGA Gene Model | MGI Sequence Detail 52705 C57BL/6J ±  kb
transcript OTTMUST00000088104 VEGA | MGI Sequence Detail 2147 Not Applicable 
polypeptide OTTMUSP00000048002 VEGA | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(284 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000248 Angiotensin II receptor family
InterPro IPR000190 Angiotensin II receptor type 1
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001252 angiotensin II receptor 1B
References (Earliest) J:1075 Sasamura H, et al., Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. Biochem Biophys Res Commun. 1992 May 29;185(1):253-9
(Latest) J:197881 Yu L, et al., Developmental expression patterns for angiotensin receptors in mouse skin and brain. J Renin Angiotensin Aldosterone Syst. 2012 Nov 30;
All references(69)
Other
accession IDs
MGD-MRK-1194, MGD-MRK-1196, MGD-MRK-1322

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory