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Afp
Gene Detail
Symbol

Name
ID
Afp
alpha fetoprotein
MGI:87951
STS
Synonyms
alpha-foetoprotein
Feature Type
protein coding gene
Genetic Map
Chromosome 5
44.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(50)
Sequence Map
Chr5:90490714-90508907 bp, + strand
From NCBI annotation of GRCm38

  18194 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36278  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: serum albumin
Gene Tree: Afp

Human
homologs
Human Homolog AFP, alpha-fetoprotein
NCBI Gene ID 174
neXtProt AC  NX_P02771
Human Synonyms  AFPD, FETA, HPAFP
Human Chr (Location)  4q13.3; chr4:73436219-73455785 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human AFP
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Females homozygous for targeted null mutations are sterile due to impairment of the hypothalamic/pituitary system and failure of the estrus cycle resulting in anovulation. Homozygous males are fertile.
 
Interactions
Afp interacts with 43 markers (Mir18b, Mir19a, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process ovulation from ovarian follicle, progesterone metabolic process, ...
Component cytoplasm, extracellular region, ...
Function beta-glucuronidase activity, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (144 records)
Data Summary: Results (257)    Tissues (101)    Images (80)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 180
Northern blot 8
Western blot 7
RT-PCR 48
RNase protection 3
Nuclease S1 5
cDNA source data(462)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(507) Genomic(24) cDNA(467) Primer pair(15) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000054932 (Evidence)
Entrez Gene11576 (Evidence)
UniGene358570
DFCITC1573775
DoTSDT.102538967, DT.102538980, DT.496212, DT.94170154
NIA Mouse Gene IndexU046009
EC3.2.1.31
Consensus CDS ProjectCCDS19413.1
International Mouse Knockout Project StatusAfp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11576 NCBI Gene Model | MGI Sequence Detail 18194 C57BL/6J ±  kb
transcript NM_007423 RefSeq | MGI Sequence Detail 2086 C57BL/6 
polypeptide P02772 UniProt | EBI | MGI Sequence Detail 605 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(2) UniProt(4)
Polymorphisms
All PCR and RFLP(11) : PCR(1) RFLP(10) SNPs within 2kb(229 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000264 ALB/AFP/VDB
InterPro IPR001703 Alpha-fetoprotein
InterPro IPR021177 Serum albumin/Alpha-fetoprotein
InterPro IPR020857 Serum albumin, conserved site
InterPro IPR020858 Serum albumin-like
InterPro IPR014760 Serum albumin, N-terminal
Protein Ontology PR:000003809 alpha-fetoprotein
Graphical View of Protein Domain Structure
References
(Earliest) J:180 Lane PW, Allelism of pr and ax. Mouse News Lett. 1962;26:35
(Latest) J:205747 Polydorou C, et al., Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation. Nat Commun. 2013;4:1658
All references(249)
Other
accession IDs
MGD-MRK-1173

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory