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Afp
Gene Detail
Symbol

Name
ID
Afp
alpha fetoprotein
MGI:87951
STS
Synonyms
alpha-foetoprotein
Feature Type
protein coding gene
Genetic Map
Chromosome 5
44.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(50)
Sequence Map
Chr5:90490737-90508907 bp, + strand
From VEGA annotation of GRCm38

  18171 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36278  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: AFP
Protein SuperFamily: serum albumin
Gene Tree: Afp

Human
homologs
AFP, alpha-fetoprotein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 174
neXtProt AC: NX_P02771

Human Synonyms: AFPD, FETA, HPAFP

Human Chr (Location): 4q13.3; chr4:73423104-73455785 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human AFP

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Females homozygous for targeted null mutations are sterile due to impairment of the hypothalamic/pituitary system and failure of the estrus cycle resulting in anovulation. Homozygous males are fertile.
 
Interactions
Afp interacts with 43 markers (Mir18b, Mir19a, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process ovulation from ovarian follicle, progesterone metabolic process, ...
Component cytoplasm, extracellular region, ...
Function beta-glucuronidase activity, metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (147 records)
Data Summary: Results (257)    Tissues (101)    Images (81)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 180
Northern blot 8
Western blot 7
RT-PCR 48
RNase protection 3
Nuclease S1 5
cDNA source data(462)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(507) Genomic(24) cDNA(467) Primer pair(15) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000055486 (Evidence)
Ensembl Gene Model ENSMUSG00000054932 (Evidence)
Entrez Gene 11576 (Evidence)
UniGene 358570
DFCI TC1573775
DoTS DT.102538967, DT.102538980, DT.496212, DT.94170154
NIA Mouse Gene Index U046009
EC 3.2.1.31
Consensus CDS Project CCDS19413.1
International Mouse Phenotyping Consortium Status Afp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055486 VEGA Gene Model | MGI Sequence Detail 18171 C57BL/6J ±  kb
transcript OTTMUST00000137327 VEGA | MGI Sequence Detail 2063 Not Applicable 
polypeptide OTTMUSP00000072342 VEGA | MGI Sequence Detail 605 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(2) UniProt(4)
Polymorphisms
All PCR and RFLP(11) : PCR(1) RFLP(10) SNPs within 2kb(229 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000264 ALB/AFP/VDB
InterPro IPR021177 Serum albumin/Alpha-fetoprotein/Afamin
InterPro IPR020857 Serum albumin, conserved site
InterPro IPR020858 Serum albumin-like
InterPro IPR014760 Serum albumin, N-terminal
Protein Ontology PR:000003809 alpha-fetoprotein
References
(Earliest) J:180 Lane PW, Allelism of pr and ax. Mouse News Lett. 1962;26:35
(Latest) J:222397 Kulinski TM, et al., Imprinted expression in cystic embryoid bodies shows an embryonic and not an extra-embryonic pattern. Dev Biol. 2015 Jun 15;402(2):291-305
All references(248)
Other
accession IDs
MGD-MRK-1173

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory