Afp
Gene Detail

Symbol Name ID

Afp alpha fetoprotein MGI:87951

STS

D5Nds4

Synonyms

alpha-foetoprotein

Feature Type

protein coding gene

Genetic Map

Chromosome 5

44.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(51)

Sequence Map

Chr5:90490714-90508907 bp, + strand From NCBI annotation of GRCm38   18194 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36278  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: serum albumin
Gene Tree: Afp

Human homologs

Human Homolog		AFP, alpha-fetoprotein
NCBI Gene ID		174
neXtProt AC		NX_P02771
Human Synonyms		FETA, HPAFP
Human Chr (Location)		4q13.3; chr4:74301933-74321492 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human AFP

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Females homozygous for targeted null mutations are sterile due to impairment of the hypothalamic/pituitary system and failure of the estrus cycle resulting in anovulation. Homozygous males are fertile.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	ovulation from ovarian follicle, progesterone metabolic process, ...
Component	cytoplasm, extracellular region, ...
Function	beta-glucuronidase activity, metal ion binding

External Resources: FuncBase

Expression

Literature Summary: (141 records)
Data Summary: Results (207)    Tissues (50)    Images (78)
Theiler Stages: 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	130
Northern blot	8
Western blot	7
RT-PCR	48
RNase protection	3
Nuclease S1	5

cDNA source data(462)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(507) Genomic(24) cDNA(467) Primer pair(15) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000054932 (Evidence)
Entrez Gene	11576 (Evidence)
UniGene	358570
DFCI	TC1573775
DoTS	DT.102538967, DT.102538980, DT.496212, DT.94170154
NIA Mouse Gene Index	U046009
EC	3.2.1.31
Consensus CDS Project	CCDS19413.1
International Mouse Knockout Project Status	Afp

Sequences

Length	Strain/Species
genomic	11576	NCBI Gene Model | MGI Sequence Detail	18194	C57BL/6J
transcript	NM_007423	RefSeq | MGI Sequence Detail	2086	C57BL/6
polypeptide	P02772	UniProt | EBI | MGI Sequence Detail	605	Not Applicable

All sequences(52) RefSeq(2) UniProt(4)

Polymorphisms

All PCR and RFLP(11) : PCR(1) RFLP(10) SNPs(178 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000264	ALB/AFP/VDB
InterPro	IPR001703	Alpha-fetoprotein
InterPro	IPR021177	Serum albumin/Alpha-fetoprotein
InterPro	IPR020857	Serum albumin, conserved site
InterPro	IPR020858	Serum albumin-like
InterPro	IPR014760	Serum albumin, N-terminal
Protein Ontology	PR:000003809	alpha-fetoprotein

Graphical View of Protein Domain Structure

References

(Earliest) J:180 Lane PW, Allelism of pr and ax. Mouse News Lett. 1962;26:35
(Latest) J:188116 Dobreva MP, et al., Periostin as a biomarker of the amniotic membrane. Stem Cells Int. 2012;2012:987185
All references(245)

Other accession IDs

MGD-MRK-1173