About   Help   FAQ
Afp Gene Detail
Summary
  • Symbol
    Afp
  • Name
    alpha fetoprotein
  • Synonyms
    alpha-foetoprotein
  • Feature Type
    protein coding gene
  • IDs
    MGI:87951
    NCBI Gene: 11576
  • Gene Overview
    MyGene.info: AFP
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:90490737-90508907 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18171 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 44.77 cM
  • Mapping Data
    50 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    AFP, alpha fetoprotein
  • Vertebrate Orthologs
    8
  • Human Ortholog
    AFP, alpha fetoprotein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AFPD, FETA, HPAFP
  • Links
    NCBI Gene ID: 174
    neXtProt AC: NX_P02771
    UniProt: P02771

  • Chr Location
    4q13.3; chr4:73436219-73455785 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 4 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Females homozygous for targeted null mutations are sterile due to impairment of the hypothalamic/pituitary system and failure of the estrus cycle resulting in anovulation. Homozygous males are fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000055486 VEGA Gene Model | MGI Sequence Detail 18171 C57BL/6J ±  kb
    transcript OTTMUST00000137327 VEGA | MGI Sequence Detail 2063 Not Applicable  
    polypeptide OTTMUSP00000072342 VEGA | MGI Sequence Detail 605 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      228 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 512
      Genomic 24
      cDNA 469
      Primer pair 18
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1173
    References
    more
    • Summaries
      All 269
      Developmental Gene Expression 158
      Gene Ontology 8
      Phenotypes 19
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:261784 Chennupati V, et al., Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation. J Clin Invest. 2018 Apr 2;128(4):1597-1614

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory