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Adra2c
Gene Detail
Symbol

Name
ID
Adra2c
adrenergic receptor, alpha 2c
MGI:87936
Synonyms
[a]2C, Adra-2c, alpha2C, alpha2-C4, subtype alpha2-C4
Feature Type
protein coding gene
Genetic Map
Chromosome 5
18.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr5:35278566-35281761 bp, + strand
From Ensembl annotation of GRCm38

  3196 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20170  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADRA2C
Protein SuperFamily: alpha-2 adrenergic receptor
Gene Tree: Adra2c

Human
homologs
ADRA2C, adrenoceptor alpha 2C
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 152
neXtProt AC: NX_P18825

Human Synonyms: ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR

Human Chr (Location): 4p16; chr4:3766569-3768526 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ADRA2C

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Radiation induced(5) Targeted(1)
Genomic Mutations involving Adra2c (6)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for targeted mutations that inactivate the gene are viable and fertile and appear grossly normal.
 
Mutations Annotated to Human Diseases (4)    Phenotype Images(4)
Interactions
Adra2c interacts with 76 markers (Mir27a, Mir27b, Mir29b-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (53)    Tissues (39)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 52
RT-PCR 1
cDNA source data(3)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase adra2c ; ZFIN adra2c    NEW 
Molecular
reagents
All nucleic(8) Genomic(2) cDNA(3) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000045318 (Evidence)
Entrez Gene 11553 (Evidence)
DFCI TC1586475, TC1673169, TC1743148
DoTS DT.55152125, DT.60100682, DT.94147697
NIA Mouse Gene Index U005497
Consensus CDS Project CCDS19226.1
International Mouse Phenotyping Consortium Status Adra2c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045318 Ensembl Gene Model | MGI Sequence Detail 3196 C57BL/6J ±  kb
transcript ENSMUST00000049545 Ensembl | MGI Sequence Detail 3196 Not Applicable 
polypeptide ENSMUSP00000059705 Ensembl | MGI Sequence Detail 458 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(14 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002233 Adrenergic receptor
InterPro IPR000735 Adrenergic receptor, alpha-2C
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001188 alpha-2C adrenergic receptor
References
(Earliest) J:11322 Oakey RJ, et al., Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution. Genomics. 1991 Jun;10(2):338-44
(Latest) J:202182 Vanzelli AS, et al., Integrative effect of carvedilol and aerobic exercise training therapies on improving cardiac contractility and remodeling in heart failure mice. PLoS One. 2013;8(5):e62452
All references(81)
Other
accession IDs
MGD-MRK-1138, MGD-MRK-1142

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory