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Adra2c Gene Detail
Summary
  • Symbol
    Adra2c
  • Name
    adrenergic receptor, alpha 2c
  • Synonyms
    [a]2C, Adra-2c, alpha2C, alpha2-C4, subtype alpha2-C4
  • Feature Type
    protein coding gene
  • IDs
    MGI:87936
    NCBI Gene: 11553
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:35435910-35439107 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 18.09 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    163 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87936
 protein coding gene Chr5:35435663-35439107 (+)
129S1/SvImJ ENSMUSG00200031122
 protein coding gene Chr5:30904852-30908296 (+)
A/J ENSMUSG00195043862
 protein coding gene Chr5:30382378-30385823 (+)
AKR/J ENSMUSG00220008172
 protein coding gene Chr5:30402732-30406177 (+)
BALB/cJ ENSMUSG00180030163
 protein coding gene Chr5:30185254-30188699 (+)
C3H/HeJ ENSMUSG00175019741
 protein coding gene Chr5:32164822-32168267 (+)
C57BL/6NJ ENSMUSG00215004616
 protein coding gene Chr5:30902094-30905539 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027145
 protein coding gene Chr5:30220300-30223748 (+)
CAST/EiJ ENSTCUG00005023975
 protein coding gene Chr5:30378820-30382265 (+)
CBA/J ENSMUSG00210004624
 protein coding gene Chr5:31133649-31137095 (+)
DBA/2J ENSMUSG00185017126
 protein coding gene Chr5:32997088-33000532 (+)
FVB/NJ ENSMUSG00205036318
 protein coding gene Chr5:29877435-29880879 (+)
JF1/MsJ ENSUMUG00000043265
 protein coding gene Chr5:37592800-37596244 (+)
LP/J ENSMUSG00230047529
 protein coding gene Chr5:37608497-37611941 (+)
NOD/ShiLtJ ENSMUSG00190011631
 protein coding gene Chr5:30159518-30162962 (+)
NZO/HlLtJ ENSMUSG00225015901
 protein coding gene Chr5:42814619-42818064 (+)
PWK/PhJ ENSLUMG00010022804
 protein coding gene Chr5:30289686-30293130 (+)
SPRET/EiJ ENSMSPG00010032206
 protein coding gene Chr5:31503631-31507077 (+)
WSB/EiJ ENSIUOG00005016375
 protein coding gene Chr5:33086464-33089908 (+)



Homology
more
  • Human Ortholog
    ADRA2C, adrenoceptor alpha 2C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADRA2C, adrenoceptor alpha 2C
  • Synonyms
    ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR
  • Links
    NCBI Gene ID: 152
    UniProt: P18825

  • Chr Location
    4p16.3; chr4:3766348-3768526 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ADRA2C associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    6
  • Radiation induced
    4
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    8 involving Adra2c
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    24 strains or lines available
Mice homozygous for targeted mutations that inactivate the gene are viable and fertile and appear grossly normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    65
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    677
  • Tissues
    58
  • cDNA Data
    4
  • Literature Summary
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 11553 NCBI Gene Model | MGI Sequence Detail 3198 C57BL/6J ±  kb
transcript NM_007418 RefSeq | MGI Sequence Detail 3214 ZRU/MplStud  
polypeptide Q01337 UniProt | EBI | MGI Sequence Detail 458 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    Genomic 2
    cDNA 4
    Primer pair 4
    Other 1
    Antibodies 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-1138, MGD-MRK-1142
References
more
  • Summaries
    All 121
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 10
    Phenotypes 68
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:341722 Gonzatti MB, et al., Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury. iScience. 2023 Oct 20;26(10):107947
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory