Adra2c
Gene Detail

Symbol Name ID

Adra2c adrenergic receptor, alpha 2c MGI:87936

Synonyms

[a]2C, Adra-2c, alpha2C, alpha2-C4, subtype alpha2-C4

Feature Type

protein coding gene

Genetic Map

Chromosome 5

18.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr5:35278566-35281761 bp, + strand From Ensembl annotation of GRCm38   3196 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20170  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: alpha-2 adrenergic receptor
Gene Tree: Adra2c

Human homologs

Human Homolog		ADRA2C, adrenoceptor alpha 2C
NCBI Gene ID		152
neXtProt AC		NX_P18825
Human Synonyms		ADRA2L2, ADRA2RL2, ADRARL2, ALPHA2CAR
Human Chr (Location)		4p16; chr4:3768296-3770253 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ADRA2C

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for targeted mutations that inactivate the gene are viable and fertile and appear grossly normal.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	activation of MAPK activity by adrenergic receptor signaling pathway, activation of protein kinase B activity, ...
Component	axon, axon terminus, ...
Function	adrenergic receptor activity, alpha-2A adrenergic receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (53)    Tissues (39)    Images (13)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	52
RT-PCR	1

cDNA source data(3)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(8) Genomic(2) cDNA(3) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000045318 (Evidence)
Entrez Gene	11553 (Evidence)
DFCI	TC1586475, TC1673169, TC1743148
DoTS	DT.55152125, DT.60100682, DT.94147697
NIA Mouse Gene Index	U005497
Consensus CDS Project	CCDS19226.1
International Mouse Knockout Project Status	Adra2c

Sequences

Length	Strain/Species
genomic	ENSMUSG00000045318	Ensembl Gene Model | MGI Sequence Detail	3196	C57BL/6J
transcript	ENSMUST00000049545	Ensembl | MGI Sequence Detail	3196	Not Applicable
polypeptide	ENSMUSP00000059705	Ensembl | MGI Sequence Detail	458	Not Applicable

All sequences(24) RefSeq(2) UniProt(1)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(7 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002233	Adrenergic receptor
InterPro	IPR000735	Adrenergic receptor, alpha-2C
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001188	alpha-2C adrenergic receptor

References

(Earliest) J:11322 Oakey RJ, et al., Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution. Genomics. 1991 Jun;10(2):338-44
(Latest) J:189969 Hsing CH, et al., alpha2-Adrenoceptor agonist dexmedetomidine protects septic acute kidney injury through increasing BMP-7 and inhibiting HDAC2 and HDAC5. Am J Physiol Renal Physiol. 2012 Nov;303(10):F1443-53
All references(77)

Other accession IDs

MGD-MRK-1138, MGD-MRK-1142