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Adra2b
Gene Detail
Symbol

Name
ID
Adra2b
adrenergic receptor, alpha 2b
MGI:87935
Synonyms
[a]2B, Adra-2b, alpha2B
Feature Type
protein coding gene
Genetic Map
Chromosome 2
61.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr2:127363208-127367221 bp, + strand
From VEGA annotation of GRCm38

  4014 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:553  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: alpha-2 adrenergic receptor
Gene Tree: Adra2b

Human
homologs
Human Homolog ADRA2B, adrenoceptor alpha 2B
NCBI Gene ID 151
neXtProt AC  NX_P18089
Human Synonyms  ADRA2L1, ADRA2RL1, ADRARL1, alpha-2BAR, ALPHA2BAR
Human Chr (Location)  2q11.1; chr2:96112875-96116149 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit poor survival and breeding, lack the vasoconstrictor response to alpha2-adrenergic receptor agonists, and display background strain dependent postnatal respiratory failure. Heterozygotes show an attenuated hypertensive response to subtotal nephrectomy and salt loading.
 
Phenotype Images(2)
Interactions
Adra2b interacts with 239 markers (Mir7-1, Mir7b, Mir10a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (49)    Tissues (34)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 48
RT-PCR 1
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(4) cDNA(13) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016023 (Evidence)
Ensembl Gene ModelENSMUSG00000058620 (Evidence)
Entrez Gene11552 (Evidence)
UniGene347390
DFCITC1585440
DoTSDT.55146675
NIA Mouse Gene IndexU002436
Consensus CDS ProjectCCDS16701.1
International Mouse Knockout Project StatusAdra2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016023 VEGA Gene Model | MGI Sequence Detail 4014 C57BL/6J ±  kb
transcript OTTMUST00000038196 VEGA | MGI Sequence Detail 4014 Not Applicable 
polypeptide OTTMUSP00000017129 VEGA | MGI Sequence Detail 448 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(81 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002233 Adrenergic receptor
InterPro IPR000207 Adrenergic receptor, alpha-2B
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001187 alpha-2B adrenergic receptor
References
(Earliest) J:2037 Chruscinski AJ, et al., Cloning and expression of the mouse homolog of the human alpha 2-C2 adrenergic receptor. Biochem Biophys Res Commun. 1992 Aug 14;186(3):1280-7
(Latest) J:198258 Noguchi TA, et al., Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos. Gene Expr Patterns. 2012 Jan 15;
All references(68)
Other
accession IDs
MGD-MRK-1137, MGD-MRK-1141

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory