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Adra2b Gene Detail
Summary
  • Symbol
    Adra2b
  • Name
    adrenergic receptor, alpha 2b
  • Synonyms
    [a]2B, Adra-2b, alpha2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:87935
    NCBI Gene: 11552
Location & Maps
more
  • Sequence Map
    Chr2:127363208-127367221 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4014 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ADRA2B, adrenoceptor alpha 2B
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ADRA2B, adrenoceptor alpha 2B
    Orthology source: HomoloGene
  • Synonyms
    ADRA2L1, ADRA2RL1, ADRARL1, alpha-2BAR, ALPHA2BAR, FAME2
  • Links
    NCBI Gene ID: 151
    neXtProt AC: NX_P18089

  • Chr Location
    2q11.1; chr2:96112875-96116245 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human ADRA2B associations

Human Disease Mouse Models
       Epilepsy, Familial Adult Myoclonic, 2; FAME2   OMIM: 607876
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    2 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Transgenic
    1
  • Genomic Mutations
    2 involving Adra2b
  • Incidental Mutations
Homozygous null mice exhibit poor survival and breeding, lack the vasoconstrictor response to alpha2-adrenergic receptor agonists, and display background strain dependent postnatal respiratory failure. Heterozygotes show an attenuated hypertensive response to subtotal nephrectomy and salt loading.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016023 VEGA Gene Model | MGI Sequence Detail 4014 C57BL/6J ±  kb
transcript OTTMUST00000038196 VEGA | MGI Sequence Detail 4014 Not Applicable  
polypeptide OTTMUSP00000017129 VEGA | MGI Sequence Detail 448 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    81 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001187 alpha-2B adrenergic receptor
  • InterPro Domains
    IPR002233 Adrenoceptor family
    IPR000207 Alpha 2B adrenoceptor
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 19
    Genomic 4
    cDNA 13
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1137, MGD-MRK-1141
References
more
  • Summaries
    All 65
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 26
  • Earliest
    J:2037 Chruscinski AJ, et al., Cloning and expression of the mouse homolog of the human alpha 2-C2 adrenergic receptor. Biochem Biophys Res Commun. 1992 Aug 14;186(3):1280-7
  • Latest
    J:217322 Jhaveri DJ, et al., Opposing effects of alpha2- and beta-adrenergic receptor stimulation on quiescent neural precursor cell activity and adult hippocampal neurogenesis. PLoS One. 2014;9(6):e98736

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory