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Adra2a Gene Detail
Summary
  • Symbol
    Adra2a
  • Name
    adrenergic receptor, alpha 2a
  • Synonyms
    Adra-2, Adra-2a, alpha2A, alpha2A-adrenergic receptor, alpha(2A)AR, alpha2A-AR
  • Feature Type
    protein coding gene
  • IDs
    MGI:87934
    NCBI Gene: 11551
  • Gene Overview
    MyGene.info: ADRA2A
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:54045182-54048982 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 49.04 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87934
protein coding gene Chr19:54045182-54048982 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025253
protein coding gene Chr19:54238904-54242704 (+)
A/J MGP_AJ_G0025229
protein coding gene Chr19:51564392-51568192 (+)
AKR/J MGP_AKRJ_G0025198
protein coding gene Chr19:53187399-53191199 (+)
BALB/cJ MGP_BALBcJ_G0025224
protein coding gene Chr19:51650885-51654685 (+)
C3H/HeJ MGP_C3HHeJ_G0024984
protein coding gene Chr19:53410465-53414265 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025667
protein coding gene Chr19:55543392-55547192 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023079
protein coding gene Chr19:50546142-50549967 (+)
CAST/EiJ MGP_CASTEiJ_G0024449
protein coding gene Chr19:53376061-53379865 (+)
CBA/J MGP_CBAJ_G0024964
protein coding gene Chr19:58317378-58321178 (+)
DBA/2J MGP_DBA2J_G0025096
protein coding gene Chr19:51378571-51382371 (+)
FVB/NJ MGP_FVBNJ_G0025057
protein coding gene Chr19:51095728-51099528 (+)
LP/J MGP_LPJ_G0025182
protein coding gene Chr19:54121997-54125797 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025090
protein coding gene Chr19:57727981-57731781 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025725
protein coding gene Chr19:53386268-53390068 (+)
PWK/PhJ MGP_PWKPhJ_G0024197
protein coding gene Chr19:51285774-51289569 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024000
protein coding gene Chr19:52073429-52077238 (+)
WSB/EiJ MGP_WSBEiJ_G0024519
protein coding gene Chr19:53514486-53518286 (+)



Homology
more
  • Human Ortholog
    ADRA2A, adrenoceptor alpha 2A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ADRA2A, adrenoceptor alpha 2A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32
  • Links
    NCBI Gene ID: 150
    neXtProt AC: NX_P08913
    UniProt: P08913

  • Chr Location
    10q25.2; chr10:111077032-111080907 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 4 alleles in 6 genetic backgrounds
    7 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene fail to produce hypotensive responsiveness to alpha2AR agonists, including failure to inhibit voltage-gated Ca2+ currents and spontaneous neuronal firing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11551 NCBI Gene Model | MGI Sequence Detail 3801 C57BL/6J ±  kb
    transcript NM_007417 RefSeq | MGI Sequence Detail 3818 C57BL/6  
    polypeptide Q01338 UniProt | EBI | MGI Sequence Detail 450 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR002233 Adrenoceptor family
      IPR001946 Alpha 2A adrenoceptor
      IPR017452 GPCR, rhodopsin-like, 7TM
      IPR000276 G protein-coupled receptor, rhodopsin-like
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 4
      cDNA 12
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1135, MGD-MRK-1136, MGD-MRK-1140, MGI:2147710
    References
    more
    • Summaries
      All 136
      Developmental Gene Expression 14
      Gene Ontology 9
      Phenotypes 71
    • Earliest
      J:10323 Yang-Feng TL, et al., Chromosomal organization of adrenergic receptor genes. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1516-20
    • Latest
      J:263116 Yu X, et al., alpha2A-adrenergic blockade attenuates septic cardiomyopathy by increasing cardiac norepinephrine concentration and inhibiting cardiac endothelial activation. Sci Rep. 2018 Apr 3;8(1):5478

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory