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Adra2a
Gene Detail
 Symbol
Name
ID
Adra2a
adrenergic receptor, alpha 2a
MGI:87934
Synonyms Adra-2, Adra-2a, alpha2A, alpha2A-adrenergic receptor, alpha(2A)AR, alpha2A-AR
Feature Type protein coding gene
Genetic Map
Chromosome 19
49.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr19:54045182-54048982 bp, + strand
From NCBI annotation of GRCm38

  3801 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47944  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: alpha-2 adrenergic receptor
Gene Tree: Adra2a

Human
homologs
Human Homolog ADRA2A, adrenoceptor alpha 2A
NCBI Gene ID 150
neXtProt AC  NX_P08913
Human Synonyms  ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32
Human Chr (Location)  10q25.2; chr10:111077032-111080907 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for targeted mutations that inactivate the gene fail to produce hypotensive responsiveness to alpha2AR agonists, including failure to inhibit voltage-gated Ca2+ currents and spontaneous neuronal firing.
 
Interactions
Adra2a interacts with 235 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (54 annotations)
Process activation of MAPK activity by adrenergic receptor signaling pathway, activation of protein kinase activity, ...
Component cytoplasm, integral component of membrane, ...
Function adrenergic receptor activity, alpha2-adrenergic receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (129)    Tissues (79)    Images (30)
Theiler Stages: 15, 17, 18, 19, 20, 21, 22, 23, 24, 28
Assay TypeResults
RNA in situ 128
RT-PCR 1
cDNA source data(8)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(4) cDNA(10) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000033717 (Evidence)
Entrez Gene11551 (Evidence)
DFCITC1598908, TC1602704
DoTSDT.101724816, DT.97348098
NIA Mouse Gene IndexU019585
Consensus CDS ProjectCCDS29905.1
International Mouse Knockout Project StatusAdra2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11551 NCBI Gene Model | MGI Sequence Detail 3801 C57BL/6J ±  kb
transcript NM_007417 RefSeq | MGI Sequence Detail 3818 C57BL/6 
polypeptide NP_031443 RefSeq | MGI Sequence Detail 465 C57BL/6 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(2 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002233 Adrenergic receptor
InterPro IPR001946 Adrenergic receptor, alpha-2A
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001186 alpha-2A adrenergic receptor
References (Earliest) J:10323 Yang-Feng TL, et al., Chromosomal organization of adrenergic receptor genes. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1516-20
(Latest) J:202182 Vanzelli AS, et al., Integrative effect of carvedilol and aerobic exercise training therapies on improving cardiac contractility and remodeling in heart failure mice. PLoS One. 2013;8(5):e62452
All references(118)
Other
accession IDs
MGD-MRK-1135, MGD-MRK-1136, MGD-MRK-1140, MGI:2147710

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory