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Adra2a Gene Detail
Summary
  • Symbol
    Adra2a
  • Name
    adrenergic receptor, alpha 2a
  • Synonyms
    Adra-2, Adra-2a, alpha2A, alpha2A-adrenergic receptor, alpha(2A)AR, alpha2A-AR
  • Feature Type
    protein coding gene
  • IDs
    MGI:87934
    NCBI Gene: 11551
  • Gene Overview
    MyGene.info: ADRA2A
Location & Maps
more
  • Sequence Map
    Chr19:54045182-54048982 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3801 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 49.04 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    ADRA2A, adrenoceptor alpha 2A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ADRA2A, adrenoceptor alpha 2A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32
  • Links
    NCBI Gene ID: 150
    neXtProt AC: NX_P08913

  • Chr Location
    10q25.2; chr10:111077032-111080907 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 4 alleles in 6 genetic backgrounds
    7 phenotypes from multigenic genotypes
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Targeted
    5
  • Transgenic
    1
  • Incidental Mutations
Mice homozygous for targeted mutations that inactivate the gene fail to produce hypotensive responsiveness to alpha2AR agonists, including failure to inhibit voltage-gated Ca2+ currents and spontaneous neuronal firing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11551 NCBI Gene Model | MGI Sequence Detail 3801 C57BL/6J ±  kb
transcript NM_007417 RefSeq | MGI Sequence Detail 3818 C57BL/6  
polypeptide NP_031443 RefSeq | MGI Sequence Detail 465 C57BL/6  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 15
    Genomic 4
    cDNA 10
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1135, MGD-MRK-1136, MGD-MRK-1140, MGI:2147710
References
more
  • Summaries
    All 121
    Developmental Gene Expression 12
    Gene Ontology 7
    Phenotypes 67
  • Earliest
    J:10323 Yang-Feng TL, et al., Chromosomal organization of adrenergic receptor genes. Proc Natl Acad Sci U S A. 1990 Feb;87(4):1516-20
  • Latest
    J:220253 Berger M, et al., Galphai/o-coupled receptor signaling restricts pancreatic beta-cell expansion. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2888-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory