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Adk
Gene Detail
Symbol

Name
ID
Adk
adenosine kinase
MGI:87930
Synonyms
2310026J05Rik, 5033405D03Rik, AK, MGC:6593
Feature Type
protein coding gene
Genetic Map
Chromosome 14
11.58 cM, cytoband A2-B
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr14:21052574-21448568 bp, + strand
From Ensembl annotation of GRCm38

  395995 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4891  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: adenosine kinase
Gene Tree: Adk

Human
homologs
Human Homolog ADK, adenosine kinase
NCBI Gene ID 132
neXtProt AC  NX_P55263
Human Synonyms  AK
Human Chr (Location)  10q22; chr10:74151185-74709303 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ADK
Mutations,
alleles, and
phenotypes
All mutations/alleles(85) : Gene trapped(82) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in death before 14 days of age, growth retardation, liver abnormalities, apnea, and impaired temperature regulation.
 
Human Diseases Modeled Using Mouse Adk (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Adk interacts with 84 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process adenosine metabolic process, AMP biosynthetic process, ...
Component cytoplasm, cytosol, ...
Function adenosine kinase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (409)    Tissues (182)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 317
RT-PCR 92
cDNA source data(167)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(168) cDNA(167) Primer pair(1)
Microarray probesets(10)
Other database
links
Ensembl Gene ModelENSMUSG00000039197 (Evidence)
Entrez Gene11534 (Evidence)
UniGene188734
DFCITC1574102, TC1591193, TC1633769, TC1664813, TC1715785
DoTSDT.101364178, DT.101393215, DT.494589, DT.87033743, DT.91583375, DT.94224519, DT.94224543, DT.94224549
NIA Mouse Gene IndexU015371
EC2.7.1.20
Consensus CDS ProjectCCDS26862.1
International Mouse Knockout Project StatusAdk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039197 Ensembl Gene Model | MGI Sequence Detail 395995 C57BL/6J ±  kb
transcript ENSMUST00000045376 Ensembl | MGI Sequence Detail 1781 Not Applicable 
polypeptide ENSMUSP00000047665 Ensembl | MGI Sequence Detail 361 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(2835 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001805 Adenosine kinase
InterPro IPR011611 Carbohydrate kinase PfkB
InterPro IPR002173 Carbohydrate/puine kinase, PfkB, conserved site
Protein Ontology PR:000003780 adenosine kinase
References
(Earliest) J:5979 Leinwand L, et al., Assignment of the gene for adenosine kinase to chromosome 14 in Mus musculus by somatic cell hybridization. Cytogenet Cell Genet. 1978;21(1-2):77-85
(Latest) J:194007 Wu M, et al., Opiate-induced changes in brain adenosine levels and narcotic drug responses. Neuroscience. 2013 Jan 3;228:235-42
All references(65)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1129, MGI:1916830, MGI:1923219, MGI:2145606, MGI:2145711

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory