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Adk Gene Detail
Summary
  • Symbol
    Adk
  • Name
    adenosine kinase
  • Synonyms
    2310026J05Rik, 5033405D03Rik, AK, MGC:6593
  • Feature Type
    protein coding gene
  • IDs
    MGI:87930
    NCBI Gene: 11534
  • Gene Overview
    MyGene.info: ADK
Location & Maps
more
  • Sequence Map
    Chr14:21052574-21448568 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      395995 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 11.58 cM, cytoband A2-B
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    ADK, adenosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADK, adenosine kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AK
  • Links
    NCBI Gene ID: 132
    neXtProt AC: NX_P55263

  • Chr Location
    10q22; chr10:74151185-74709303 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Adk mouse models; 1 with human ADK associations

Human Disease Mouse Models
       Visceral Steatosis, Congenital   OMIM: 228100 View 1 model
       Hypermethioninemia Due to Adenosine Kinase Deficiency   OMIM: 614300
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    86
  • Gene trapped
    82
  • Targeted
    3
  • Transgenic
    1
  • Incidental Mutations
Homozygous mutation of this gene results in death before 14 days of age, growth retardation, liver abnormalities, apnea, and impaired temperature regulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039197 Ensembl Gene Model | MGI Sequence Detail 395995 C57BL/6J ±  kb
transcript ENSMUST00000045376 Ensembl | MGI Sequence Detail 1781 Not Applicable  
polypeptide ENSMUSP00000047665 Ensembl | MGI Sequence Detail 361 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2828 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 168
    cDNA 167
    Primer pair 1

    Microarray probesets 10
Other
Accession IDs
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MGD-MRK-1129, MGI:1916830, MGI:1923219, MGI:2145606, MGI:2145711
References
more
  • Summaries
    All 60
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 9
    Phenotypes 18
  • Earliest
    J:5979 Leinwand L, et al., Assignment of the gene for adenosine kinase to chromosome 14 in Mus musculus by somatic cell hybridization. Cytogenet Cell Genet. 1978;21(1-2):77-85
  • Latest
    J:217047 Diogenes MJ, et al., Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase. Cereb Cortex. 2014 Jan;24(1):67-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory