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Adh7
Gene Detail
Symbol

Name
ID
Adh7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
MGI:87926
Synonyms
Adh3, Adh-3, Adh-3e, Adh3-e, Adh-3t, Adh3-t, Adh4, Adt-1, IV ADH
Feature Type
protein coding gene
Genetic Map
Chromosome 3
64.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(39)
Sequence Map
Chr3:138217760-138233382 bp, + strand
From VEGA annotation of GRCm38

  15623 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37333  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: ADH7
Protein SuperFamily: alcohol dehydrogenase
Gene Tree: Adh7

Human
homologs
ADH7, alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 131
neXtProt AC: NX_P40394

Human Synonyms: ADH4

Human Chr (Location): 4q23-q24; chr4:99412261-99435510 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutation of this gene results in defective ethanol clearance and reduced metabolism of retinal to retinoic acid.
 
Human Diseases Modeled in Mice Using Adh7 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Adh7 interacts with 253 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (12 records)
Data Summary: Results (238)    Tissues (135)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 231
RT-PCR 7
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100487608    NEW 
Molecular
reagents
All nucleic(24) Genomic(2) cDNA(20) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000052803 (Evidence)
Ensembl Gene Model ENSMUSG00000055301 (Evidence)
Entrez Gene 11529 (Evidence)
UniGene 8473
DFCI TC1583015
DoTS DT.526608
NIA Mouse Gene Index U003908
EC 1.1.1.1
Consensus CDS Project CCDS38651.1
International Mouse Phenotyping Consortium Status Adh7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052803 VEGA Gene Model | MGI Sequence Detail 15623 C57BL/6J ±  kb
transcript OTTMUST00000132157 VEGA | MGI Sequence Detail 3432 Not Applicable 
polypeptide OTTMUSP00000070502 VEGA | MGI Sequence Detail 374 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(198 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013149 Alcohol dehydrogenase, C-terminal
InterPro IPR028635 Alcohol dehydrogenase family, zinc-type, class-IV subfamily
InterPro IPR013154 Alcohol dehydrogenase, N-terminal
InterPro IPR002085 Alcohol dehydrogenase superfamily, zinc-type
InterPro IPR002328 Alcohol dehydrogenase, zinc-type, conserved site
InterPro IPR011032 GroES-like
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000003773 alcohol dehydrogenase class 4 mu/sigma chain
References
(Earliest) J:5932 Holmes RS, The genetics of alpha-hydroxyacid oxidase and alcohol dehydrogenase in the mouse: evidence for multiple gene loci and linkage between Hao-2 and Adh-3. Genetics. 1977 Dec;87(4):709-16
(Latest) J:180672 Anvret A, et al., Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease. Behav Brain Res. 2012 Feb 1;227(1):252-7
All references(82)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1116, MGD-MRK-1117, MGD-MRK-1118, MGD-MRK-1125, MGD-MRK-1126, MGD-MRK-1127, MGD-MRK-1166, MGD-MRK-35651, MGI:107190, MGI:2139678, MGI:87927, MGI:87928

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory