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Adh7 Gene Detail
Summary
  • Symbol
    Adh7
  • Name
    alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
  • Synonyms
    Adh-3, Adh3, Adh3-e, Adh-3e, Adh3-t, Adh-3t, Adh4, Adt-1, IV ADH
  • Feature Type
    protein coding gene
  • IDs
    MGI:87926
    NCBI Gene: 11529
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:137923521-137939143 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 64.13 cM
  • Mapping Data
    39 experiments
Strain
Comparison
more
  • SNPs within 2kb
    561 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87926
 protein coding gene Chr3:137903828-137939143 (+)
129S1/SvImJ ENSMUSG00200002850
 protein coding gene Chr3:134686160-134724086 (+)
A/J ENSMUSG00195004302
 protein coding gene Chr3:134794559-134832508 (+)
AKR/J ENSMUSG00220002855
 protein coding gene Chr3:133245130-133283053 (+)
BALB/cJ ENSMUSG00180011269
 protein coding gene Chr3:134708655-134746599 (+)
C3H/HeJ ENSMUSG00175019022
 protein coding gene Chr3:134311992-134349931 (+)
C57BL/6NJ ENSMUSG00215017961
 protein coding gene Chr3:135082886-135098503 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025678
 protein coding gene Chr3:131677634-131693538 (+)
CAST/EiJ ENSTCUG00005029004
 protein coding gene Chr3:135411672-135441819 (+)
CBA/J ENSMUSG00210030644
 protein coding gene Chr3:134921831-134959774 (+)
DBA/2J ENSMUSG00185003529
 protein coding gene Chr3:135538990-135576916 (+)
FVB/NJ ENSMUSG00205021118
 protein coding gene Chr3:133846660-133884585 (+)
JF1/MsJ ENSUMUG00000003934
 protein coding gene Chr3:134317315-134350720 (+)
LP/J ENSMUSG00230002493
 protein coding gene Chr3:137499887-137537812 (+)
NOD/ShiLtJ ENSMUSG00190004227
 protein coding gene Chr3:135920268-135958195 (+)
NZO/HlLtJ ENSMUSG00225004606
 protein coding gene Chr3:139967876-140005792 (+)
PWK/PhJ ENSLUMG00010020058
 protein coding gene Chr3:134227967-134261441 (+)
SPRET/EiJ ENSMSPG00010013731
 protein coding gene Chr3:135416889-135433877 (+)
WSB/EiJ ENSIUOG00005017905
 protein coding gene Chr3:135118882-135134509 (+)



Homology
more
  • Human Ortholog
    ADH7, alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADH7, alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
  • Links
    NCBI Gene ID: 131
    UniProt: P40394

  • Chr Location
    4q23; chr4:99412261-99435510 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Adh7 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in defective ethanol clearance and reduced metabolism of retinal to retinoic acid.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    917
  • Tissues
    197
  • cDNA Data
    24
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055301 Ensembl Gene Model | MGI Sequence Detail 15623 C57BL/6J ±  kb
    transcript ENSMUST00000090171 Ensembl | MGI Sequence Detail 3432 Not Applicable  
    polypeptide ENSMUSP00000087633 Ensembl | MGI Sequence Detail 374 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 2
      cDNA 24
      Primer pair 2
      Other 1
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1116, MGD-MRK-1117, MGD-MRK-1118, MGD-MRK-1125, MGD-MRK-1126, MGD-MRK-1127, MGD-MRK-1166, MGD-MRK-35651, MGI:107190, MGI:2139678, MGI:87927, MGI:87928
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 12
      Diseases 2
      Gene Ontology 17
      Phenotypes 15
    • Earliest
      J:5932 Holmes RS, The genetics of alpha-hydroxyacid oxidase and alcohol dehydrogenase in the mouse: evidence for multiple gene loci and linkage between Hao-2 and Adh-3. Genetics. 1977 Dec;87(4):709-16
    • Latest
      J:364860 Wang H, et al., The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression patterns through regulation of WDR5 stability. Elife. 2024 Nov 11;13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory