Adh7
Gene Detail

Symbol Name ID

Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide MGI:87926

Synonyms

Adh3, Adh-3, Adh-3e, Adh3-e, Adh-3t, Adh3-t, Adh4, Adt-1, IV ADH

Feature Type

protein coding gene

Genetic Map

Chromosome 3

64.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(39)

Sequence Map

Chr3:138217773-138232042 bp, + strand From NCBI annotation of GRCm38   14270 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37333  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: alcohol dehydrogenase
Gene Tree: Adh7

Human homologs

Human Homolog		ADH7, alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
NCBI Gene ID		131
neXtProt AC		NX_P40394
Human Synonyms		ADH4
Human Chr (Location)		4q23-q24; chr4:100333418-100356667 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous mutation of this gene results in defective ethanol clearance and reduced metabolism of retinal to retinoic acid.

 
Human Diseases Modeled Using Mouse Adh7 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	ethanol catabolic process, ethanol metabolic process, ...
Component	cytoplasm, extracellular region, ...
Function	alcohol dehydrogenase activity, zinc-dependent, alcohol dehydrogenase (NAD) activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (240)    Tissues (138)    Images (23)
Theiler Stages: 1, 3, 4, 9, 10, 11, 12, 13, 14, 15, 22, 28

Assay Type	Results
RNA in situ	231
RT-PCR	9

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) Genomic(2) cDNA(20) Primer pair(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000055301 (Evidence)
Entrez Gene	11529 (Evidence)
UniGene	8473
DFCI	TC1583015
DoTS	DT.526608
NIA Mouse Gene Index	U003908
EC	1.1.1.1
Consensus CDS Project	CCDS38651.1
International Mouse Knockout Project Status	Adh7

Sequences

Length	Strain/Species
genomic	11529	NCBI Gene Model | MGI Sequence Detail	14270	C57BL/6J
transcript	NM_009626	RefSeq | MGI Sequence Detail	2079	C57BL/6
polypeptide	Q64437	UniProt | EBI | MGI Sequence Detail	374	Not Applicable

All sequences(30) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(127 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013149	Alcohol dehydrogenase, C-terminal
InterPro	IPR013154	Alcohol dehydrogenase GroES-like
InterPro	IPR002085	Alcohol dehydrogenase superfamily, zinc-type
InterPro	IPR002328	Alcohol dehydrogenase, zinc-type, conserved site
InterPro	IPR011032	GroES-like
InterPro	IPR016040	NAD(P)-binding domain
Protein Ontology	PR:000003773	alcohol dehydrogenase class 4 mu/sigma chain

Graphical View of Protein Domain Structure

References

(Earliest) J:5932 Holmes RS, The genetics of alpha-hydroxyacid oxidase and alcohol dehydrogenase in the mouse: evidence for multiple gene loci and linkage between Hao-2 and Adh-3. Genetics. 1977 Dec;87(4):709-16
(Latest) J:180672 Anvret A, et al., Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease. Behav Brain Res. 2012 Feb 1;227(1):252-7
All references(83)

Other accession IDs

MGD-MRK-1116, MGD-MRK-1117, MGD-MRK-1118, MGD-MRK-1125, MGD-MRK-1126, MGD-MRK-1127, MGD-MRK-1166, MGD-MRK-35651, MGI:107190, MGI:2139678, MGI:87927, MGI:87928