About   Help   FAQ
Adh7
Gene Detail
 Symbol
Name
ID
Adh7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
MGI:87926
Synonyms Adh3, Adh-3, Adh-3e, Adh3-e, Adh-3t, Adh3-t, Adh4, Adt-1, IV ADH
Feature Type protein coding gene
Genetic Map
Chromosome 3
64.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(39)
Sequence Map
Chr3:138217773-138232042 bp, + strand
From NCBI annotation of GRCm38

  14270 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37333  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Protein SuperFamily: alcohol dehydrogenase
Gene Tree: Adh7

Human
homologs
Human Homolog ADH7, alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
NCBI Gene ID 131
neXtProt AC  NX_P40394
Human Synonyms  ADH4
Human Chr (Location)  4q23-q24; chr4:99412261-99435510 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in defective ethanol clearance and reduced metabolism of retinal to retinoic acid.
 
Human Diseases Modeled Using Mouse Adh7 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process ethanol catabolic process, ethanol metabolic process, ...
Component cytoplasm, extracellular region, ...
Function alcohol dehydrogenase activity, zinc-dependent, alcohol dehydrogenase (NAD) activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (241)    Tissues (138)    Images (24)
Theiler Stages: 1, 3, 4, 9, 10, 11, 12, 13, 14, 15, 22, 28
Assay TypeResults
RNA in situ 231
RT-PCR 10
cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(24) Genomic(2) cDNA(20) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000055301 (Evidence)
Entrez Gene11529 (Evidence)
UniGene8473
DFCITC1583015
DoTSDT.526608
NIA Mouse Gene IndexU003908
EC1.1.1.1
Consensus CDS ProjectCCDS38651.1
International Mouse Knockout Project StatusAdh7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11529 NCBI Gene Model | MGI Sequence Detail 14270 C57BL/6J ±  kb
transcript NM_009626 RefSeq | MGI Sequence Detail 2079 C57BL/6 
polypeptide Q64437 UniProt | EBI | MGI Sequence Detail 374 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(189 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013149 Alcohol dehydrogenase, C-terminal
InterPro IPR013154 Alcohol dehydrogenase GroES-like
InterPro IPR002085 Alcohol dehydrogenase superfamily, zinc-type
InterPro IPR002328 Alcohol dehydrogenase, zinc-type, conserved site
InterPro IPR011032 GroES-like
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000003773 alcohol dehydrogenase class 4 mu/sigma chain
Graphical View of Protein Domain Structure
References (Earliest) J:5932 Holmes RS, The genetics of alpha-hydroxyacid oxidase and alcohol dehydrogenase in the mouse: evidence for multiple gene loci and linkage between Hao-2 and Adh-3. Genetics. 1977 Dec;87(4):709-16
(Latest) J:180672 Anvret A, et al., Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease. Behav Brain Res. 2012 Feb 1;227(1):252-7
All references(83)
Other
accession IDs
MGD-MRK-1116, MGD-MRK-1117, MGD-MRK-1118, MGD-MRK-1125, MGD-MRK-1126, MGD-MRK-1127, MGD-MRK-1166, MGD-MRK-35651, MGI:107190, MGI:2139678, MGI:87927, MGI:87928

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory