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Adh1 Gene Detail
Summary
  • Symbol
    Adh1
  • Name
    alcohol dehydrogenase 1 (class I)
  • Synonyms
    Adh-1, Adh-1e, Adh1-e, Adh-1t, Adh-1-t, Adh1-t, Adh1tl, ADH-AA, class I alcohol dehydrogenase
  • Feature Type
    protein coding gene
  • IDs
    MGI:87921
    NCBI Gene: 11522
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:138277645-138290691 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 64.16 cM
  • Mapping Data
    15 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87921
protein coding gene Chr3:138260991-138290698 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027928
protein coding gene Chr3:141313653-141343867 (+)
A/J MGP_AJ_G0027885
protein coding gene Chr3:136305524-136332885 (+)
AKR/J MGP_AKRJ_G0027851
protein coding gene Chr3:139932895-139960138 (+)
BALB/cJ MGP_BALBcJ_G0027897
protein coding gene Chr3:136112336-136139957 (+)
C3H/HeJ MGP_C3HHeJ_G0027627
protein coding gene Chr3:140256489-140283897 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028341
protein coding gene Chr3:146174047-146207938 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025679
protein coding gene Chr3:131721847-131753089 (+)
CAST/EiJ MGP_CASTEiJ_G0027083
protein coding gene Chr3:140025902-140055877 (+)
CBA/J MGP_CBAJ_G0027604
protein coding gene Chr3:151142960-151170068 (+)
DBA/2J MGP_DBA2J_G0027743
protein coding gene Chr3:135425689-135453750 (+)
FVB/NJ MGP_FVBNJ_G0027710
protein coding gene Chr3:132885589-132914679 (+)
LP/J MGP_LPJ_G0027853
protein coding gene Chr3:142699034-142727550 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027742
protein coding gene Chr3:159234027-159266559 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028399
protein coding gene Chr3:139471445-139499808 (+)
PWK/PhJ MGP_PWKPhJ_G0026807
protein coding gene Chr3:135183439-135214219 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026634
protein coding gene Chr3:137577313-137606732 (+)
WSB/EiJ MGP_WSBEiJ_G0027162
protein coding gene Chr3:140313649-140346559 (+)



Homology
more
  • Human Ortholog
    ADH1A, alcohol dehydrogenase 1A (class I), alpha polypeptide
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADH1A, alcohol dehydrogenase 1A (class I), alpha polypeptide
    Orthology source: HGNC
  • Synonyms
    ADH1
  • Links
    NCBI Gene ID: 124
    neXtProt AC: NX_P07327
    UniProt: P07327

  • Chr Location
    4q23; chr4:99276366-99291028 (-)  GRCh38.p7

  • Human Ortholog
    ADH1B, alcohol dehydrogenase 1B (class I), beta polypeptide
    Orthology source: HGNC
  • Synonyms
    ADH2, HEL-S-117
  • Links
    NCBI Gene ID: 125
    neXtProt AC: NX_P00325
    UniProt: P00325

  • Chr Location
    4q23; chr4:99306387-99321442 (-)  GRCh38.p7

  • Human Ortholog
    ADH1C, alcohol dehydrogenase 1C (class I), gamma polypeptide
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADH3
  • Links
    NCBI Gene ID: 126
    neXtProt AC: NX_P00326
    UniProt: P00326

  • Chr Location
    4q23; chr4:99336492-99353045 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human ADH1B,ADH1C associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 1 genetic background
    3 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired metabolism of (and sensitivity to) ethanol and retinol.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11522 NCBI Gene Model | MGI Sequence Detail 13047 C57BL/6J ±  kb
    transcript NM_007409 RefSeq | MGI Sequence Detail 1413 Not Specified  
    polypeptide P00329 UniProt | EBI | MGI Sequence Detail 375 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 9
      cDNA 24
      Primer pair 6

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-1111, MGD-MRK-1112, MGD-MRK-1113, MGD-MRK-1115, MGD-MRK-1120, MGD-MRK-1121, MGD-MRK-1123, MGD-MRK-1124, MGI:2139643, MGI:87922, MGI:87924, MGI:87925
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 17
      Phenotypes 10
    • Earliest
      J:6249 Holmes RS, Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3. Biochem Genet. 1979 Jun;17(5-6):461-72
    • Latest
      J:249092 Pang J, et al., Alcohol Dehydrogenase Protects against Endoplasmic Reticulum Stress-Induced Myocardial Contractile Dysfunction via Attenuation of Oxidative Stress and Autophagy: Role of PTEN-Akt-mTOR Signaling. PLoS One. 2016;11(1):e0147322

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory