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Adh1
Gene Detail
Symbol

Name
ID
Adh1
alcohol dehydrogenase 1 (class I)
MGI:87921
STS
Synonyms
Adh-1, Adh-1e, Adh1-e, Adh-1t, Adh-1-t, Adh1-t, Adh1tl, ADH-AA, class I alcohol dehydrogenase
Feature Type
protein coding gene
Genetic Map
Chromosome 3
64.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr3:138260991-138290698 bp, + strand
From VEGA annotation of GRCm38

  29708 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:73888  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog

Protein SuperFamily: alcohol dehydrogenase
Gene Tree: Adh1

Human
homologs
Human Homolog ADH1C, alcohol dehydrogenase 1C (class I), gamma polypeptide
NCBI Gene ID 126
neXtProt AC  NX_P00326
Human Synonyms  ADH3
Human Chr (Location)  4q23; chr4:99336492-99352760 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human ADH1C
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit impaired metabolism of (and sensitivity to) ethanol and retinol.
 
Interactions
Adh1 interacts with 160 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process acetaldehyde biosynthetic process, behavioral response to ethanol, ...
Component cytoplasm, cytosol, ...
Function alcohol dehydrogenase (NAD) activity, drug binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (250)    Tissues (171)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 215
Northern blot 5
RT-PCR 30
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(35) Genomic(9) cDNA(20) Primer pair(6)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000034747 (Evidence)
Ensembl Gene ModelENSMUSG00000074207 (Evidence)
Entrez Gene11522 (Evidence)
DFCITC1573340
DoTSDT.101714693, DT.537179, DT.97335280
NIA Mouse Gene IndexU024699, U116865
EC1.1.1.1
Consensus CDS ProjectCCDS17867.1
International Mouse Knockout Project StatusAdh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034747 VEGA Gene Model | MGI Sequence Detail 29708 C57BL/6J ±  kb
transcript OTTMUST00000088306 VEGA | MGI Sequence Detail 1492 Not Applicable 
polypeptide OTTMUSP00000048109 VEGA | MGI Sequence Detail 375 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(247 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013149 Alcohol dehydrogenase, C-terminal
InterPro IPR013154 Alcohol dehydrogenase GroES-like
InterPro IPR002085 Alcohol dehydrogenase superfamily, zinc-type
InterPro IPR002328 Alcohol dehydrogenase, zinc-type, conserved site
InterPro IPR011032 GroES-like
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000004555 alcohol dehydrogenase 1
References
(Earliest) J:6249 Holmes RS, Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3. Biochem Genet. 1979 Jun;17(5-6):461-72
(Latest) J:180672 Anvret A, et al., Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease. Behav Brain Res. 2012 Feb 1;227(1):252-7
All references(90)
Other
accession IDs
MGD-MRK-1111, MGD-MRK-1112, MGD-MRK-1113, MGD-MRK-1115, MGD-MRK-1120, MGD-MRK-1121, MGD-MRK-1123, MGD-MRK-1124, MGI:2139643, MGI:87922, MGI:87924, MGI:87925

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory