Adh1
Gene Detail

Symbol Name ID

Adh1 alcohol dehydrogenase 1 (class I) MGI:87921

STS

D3Nds9

Synonyms

Adh-1, Adh-1e, Adh1-e, Adh-1t, Adh-1-t, Adh1-t, Adh1tl, ADH-AA, class I alcohol dehydrogenase

Feature Type

protein coding gene

Genetic Map

Chromosome 3

64.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr3:138260991-138290698 bp, + strand From VEGA annotation of GRCm38   29708 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Adh1 ± 2 cM)

Protein SuperFamily: alcohol dehydrogenase
Gene Tree: Adh1

Human ortholog

ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide NCBI Gene ID 126
Human Synonyms: ADH3
Human Chr4:100257649-100273917 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human ADH1C (2)

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygotes for targeted null mutations exhibit impaired metabolism of (and sensitivity to) ethanol and retinol.

 

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	acetaldehyde biosynthetic process, behavioral response to ethanol, ...
Component	cytoplasm, cytosol, ...
Function	alcohol dehydrogenase (NAD) activity, drug binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (214)    Tissues (136)    Images (40)
Theiler Stages: 1, 3, 4, 9, 11, 13, 15, 17, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	177
Northern blot	5
RT-PCR	32

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(34) Genomic(9) cDNA(19) Primer pair(6)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000034747 (Evidence)
Ensembl Gene Model	ENSMUSG00000074207 (Evidence)
Entrez Gene	11522 (Evidence)
DFCI	TC1573340
DoTS	DT.101714693, DT.537179, DT.97335280
NIA Mouse Gene Index	U024699, U116865
EC	1.1.1.1
Consensus CDS Project	CCDS17867.1
International Mouse Knockout Project Status	Adh1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034747	VEGA Gene Model | MGI Sequence Detail	29708	C57BL/6J
transcript	OTTMUST00000088306	VEGA | MGI Sequence Detail	1492	Not Applicable
polypeptide	OTTMUSP00000048109	VEGA | MGI Sequence Detail	375	Not Applicable

All sequences(38) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs(95 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013149	Alcohol dehydrogenase, C-terminal
InterPro	IPR013154	Alcohol dehydrogenase GroES-like
InterPro	IPR002085	Alcohol dehydrogenase superfamily, zinc-type
InterPro	IPR002328	Alcohol dehydrogenase, zinc-type, conserved site
InterPro	IPR011032	GroES-like
InterPro	IPR016040	NAD(P)-binding domain
Protein Ontology	PR:000004555	alcohol dehydrogenase 1

References

(Earliest) J:6249 Holmes RS, Genetics and ontogeny of alcohol dehydrogenase isozymes in the mouse: evidence for a cis-acting regulator gene (Adt-i) controlling C2 isozyme expression in reproductive tissues and close linkage of Adh-3 and Adt-i on chromosome 3. Biochem Genet. 1979 Jun;17(5-6):461-72
(Latest) J:180672 Anvret A, et al., Adh1 and Adh1/4 knockout mice as possible rodent models for presymptomatic Parkinson's disease. Behav Brain Res. 2012 Feb 1;227(1):252-7
All references(90)

Other accession IDs

MGD-MRK-1111, MGD-MRK-1112, MGD-MRK-1113, MGD-MRK-1115, MGD-MRK-1120, MGD-MRK-1121, MGD-MRK-1123, MGD-MRK-1124, MGI:2139643, MGI:87922, MGI:87924, MGI:87925