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Plin2
Gene Detail
Symbol

Name
ID
Plin2
perilipin 2
MGI:87920
Synonyms
Adfp, adipophilin, ADPH, Adrp
Feature Type
protein coding gene
Genetic Map
Chromosome 4
40.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:86648386-86670060 bp, - strand
From VEGA annotation of GRCm38

  21675 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:872  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PLIN2
Protein SuperFamily: lipid droplet-associated protein, perilipin type
Gene Tree: Plin2

Human
homologs
PLIN2, perilipin 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 123
neXtProt AC: NX_Q99541

Human Synonyms: ADFP, ADRP

Human Chr (Location): 9p22.1; chr9:19108388-19127606 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from APF )
 
Male mice homozygous for one knock-out allele are infertile. Mice homozygous to a different knock-out allele exhibit eye defects. Mice homozygous for a different knock-out allele exhibit difficulty raising the first litter and increased resistance to diet induced obesity and hepatic steatosis.
 
Interactions
Plin2 interacts with 66 markers (Mir15a, Mir22, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process lipid storage, long-chain fatty acid transport
Component cytoplasm, cytosol, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 1
cDNA source data(367)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase plin2 ; ZFIN plin2    NEW 
Molecular
reagents
All nucleic(379) Genomic(11) cDNA(367) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000007453 (Evidence)
Ensembl Gene Model ENSMUSG00000028494 (Evidence)
Entrez Gene 11520 (Evidence)
UniGene 381
DFCI TC1573348, TC1650896
DoTS DT.101720511, DT.55104410, DT.97379230, DT.99867312
NIA Mouse Gene Index U025230, U109880
Consensus CDS Project CCDS18308.1
International Mouse Phenotyping Consortium Status Plin2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007453 VEGA Gene Model | MGI Sequence Detail 21675 C57BL/6J ±  kb
transcript OTTMUST00000017238 VEGA | MGI Sequence Detail 1888 Not Applicable 
polypeptide OTTMUSP00000007962 VEGA | MGI Sequence Detail 425 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(6) UniProt(7)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(131 from dbSNP Build 137)    SNPs within 2kb including multiple locations(165)
Protein-related
information
ResourceIDDescription
InterPro IPR004279 Perilipin
Protein Ontology PR:000003766 perilipin-2
References
(Earliest) J:2265 Jiang HP, et al., Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7856-60
(Latest) J:217352 Carr RM, et al., Absence of perilipin 2 prevents hepatic steatosis, glucose intolerance and ceramide accumulation in alcohol-fed mice. PLoS One. 2014;9(5):e97118
All references(76)
Other
accession IDs
MGD-MRK-1110, MGD-MRK-1154, MGI:2140117

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory