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Plin2 Gene Detail
Summary
  • Symbol
    Plin2
  • Name
    perilipin 2
  • Synonyms
    Adfp, adipophilin, ADPH, Adrp
  • Feature Type
    protein coding gene
  • IDs
    MGI:87920
    NCBI Gene: 11520
  • Alliance
    genome feature page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:86566623-86588297 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 40.69 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    717 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87920
 protein coding gene Chr4:86545147-86588518 (-)
129S1/SvImJ ENSMUSG00200000519
 protein coding gene Chr4:81494419-81559531 (-)
A/J ENSMUSG00195008349
 protein coding gene Chr4:82073703-82138825 (-)
AKR/J ENSMUSG00220007593
 protein coding gene Chr4:81487199-81531021 (-)
BALB/cJ ENSMUSG00180005746
 protein coding gene Chr4:81038615-81103731 (-)
C3H/HeJ ENSMUSG00175004016
 protein coding gene Chr4:81961055-82026095 (-)
C57BL/6NJ ENSMUSG00215012924
 protein coding gene Chr4:81938317-81982137 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026133
 protein coding gene Chr4:79479521-79519928 (-)
CAST/EiJ ENSTCUG00005000775
 protein coding gene Chr4:81359076-81422845 (-)
CBA/J ENSMUSG00210001179
 protein coding gene Chr4:81547783-81612821 (-)
DBA/2J ENSMUSG00185002886
 protein coding gene Chr4:82155447-82220581 (-)
FVB/NJ ENSMUSG00205001234
 protein coding gene Chr4:80455223-80499033 (-)
JF1/MsJ ENSUMUG00000001441
 protein coding gene Chr4:82437442-82479151 (-)
LP/J ENSMUSG00230014993
 protein coding gene Chr4:85575710-85640834 (-)
NOD/ShiLtJ ENSMUSG00190016116
 protein coding gene Chr4:81016837-81060635 (-)
NZO/HlLtJ ENSMUSG00225005281
 protein coding gene Chr4:90664577-90729615 (-)
PWK/PhJ ENSLUMG00010001614
 protein coding gene Chr4:80256715-80320898 (-)
SPRET/EiJ ENSMSPG00010014124
 protein coding gene Chr4:82044565-82057465 (-)
WSB/EiJ ENSIUOG00005012055
 protein coding gene Chr4:81380175-81430439 (-)



Homology
more
  • Human Ortholog
    PLIN2, perilipin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLIN2, perilipin 2
  • Synonyms
    ADFP, ADRP
  • Links
    NCBI Gene ID: 123
    UniProt: Q99541

  • Chr Location
    9p22.1; chr9:19108375-19149369 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 4 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null mutations are resistant to diet-induced obesity and hepatic steatosis and may exhibit altered milk composition, vision abnormalities, or small sebaceous glands. Male mice homozygous for a gene trap allele are infertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    629
  • Tissues
    11
  • cDNA Data
    368
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028494 Ensembl Gene Model | MGI Sequence Detail 21675 C57BL/6J ±  kb
    transcript ENSMUST00000000466 Ensembl | MGI Sequence Detail 1888 Not Applicable  
    polypeptide ENSMUSP00000000466 Ensembl | MGI Sequence Detail 425 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 383
      Genomic 11
      cDNA 368
      Primer pair 4
      Antibodies 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1110, MGD-MRK-1154, MGI:2140117
    References
    more
    • Summaries
      All 168
      Developmental Gene Expression 33
      Gene Ontology 15
      Phenotypes 48
    • Earliest
      J:2265 Jiang HP, et al., Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7856-60
    • Latest
      J:384922 Gong S, et al., In vivo visualization of lipophagy dynamics using the tfLiveDrop reporter mice. J Lipid Res. 2026 Apr 2;67(5):101033
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory