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Plin2
Gene Detail
 Symbol
Name
ID
Plin2
perilipin 2
MGI:87920
Synonyms Adfp, adipophilin, ADPH, Adrp
Feature Type protein coding gene
Genetic Map
Chromosome 4
40.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:86648386-86670060 bp, - strand
From VEGA annotation of GRCm38

  21675 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:872  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: lipid droplet-associated protein, perilipin type
Gene Tree: Plin2

Human
homologs
Human Homolog PLIN2, perilipin 2
NCBI Gene ID 123
neXtProt AC  NX_Q99541
Human Synonyms  ADFP, ADRP
Human Chr (Location)  9p22.1; chr9:19108388-19127606 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(3) Targeted(5)
Incidental mutations (data from APF )
 
Male mice homozygous for one knock-out allele are infertile. Mice homozygous to a different knock-out allele exhibit eye defects. Mice homozygous for a different knock-out allele exhibit difficulty raising the first litter and increased resistance to diet induced obesity and hepatic steatosis.
 
Interactions
Plin2 interacts with 66 markers (Mir15a, Mir22, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process lipid storage, long-chain fatty acid transport
Component cytoplasm, cytosol, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 22
Assay TypeResults
RNA in situ 1
cDNA source data(367)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(379) Genomic(11) cDNA(367) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000007453 (Evidence)
Ensembl Gene ModelENSMUSG00000028494 (Evidence)
Entrez Gene11520 (Evidence)
UniGene381
DFCITC1573348, TC1650896
DoTSDT.101720511, DT.55104410, DT.97379230, DT.99867312
Consensus CDS ProjectCCDS18308.1
International Mouse Knockout Project StatusPlin2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007453 VEGA Gene Model | MGI Sequence Detail 21675 C57BL/6J ±  kb
transcript OTTMUST00000017238 VEGA | MGI Sequence Detail 1888 Not Applicable 
polypeptide OTTMUSP00000007962 VEGA | MGI Sequence Detail 425 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(4) UniProt(7)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(131 from dbSNP Build 137)    SNPs within 2kb including multiple locations(165)
Protein-related
information
ResourceIDDescription
InterPro IPR004279 Perilipin
Protein Ontology PR:000003766 perilipin-2
References (Earliest) J:2265 Jiang HP, et al., Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7856-60
(Latest) J:202513 Dahlhoff M, et al., PLIN2, the major perilipin regulated during sebocyte differentiation, controls sebaceous lipid accumulation in vitro and sebaceous gland size in vivo. Biochim Biophys Acta. 2013 Oct;1830(10):4642-9
All references(74)
Other
accession IDs
MGD-MRK-1110, MGD-MRK-1154, MGI:2140117

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory