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Plin2 Gene Detail
Summary
  • Symbol
    Plin2
  • Name
    perilipin 2
  • Synonyms
    Adfp, adipophilin, ADPH, Adrp
  • Feature Type
    protein coding gene
  • IDs
    MGI:87920
    NCBI Gene: 11520
Location & Maps
more
  • Sequence Map
    Chr4:86648386-86670060 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21675 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 40.69 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    PLIN2, perilipin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLIN2, perilipin 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADFP, ADRP
  • Links
    NCBI Gene ID: 123
    neXtProt AC: NX_Q99541

  • Chr Location
    9p22.1; chr9:19108388-19127606 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 5 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    2
  • Gene trapped
    3
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    3 involving Plin2
  • Incidental Mutations
    APF
Homozygotes for null mutations are resistant to diet-induced obesity and hepatic steatosis and may exhibit altered milk composition, vision abnormalities, or small sebaceous glands. Male mice homozygous for a gene trap allele are infertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007453 VEGA Gene Model | MGI Sequence Detail 21675 C57BL/6J ±  kb
transcript OTTMUST00000017238 VEGA | MGI Sequence Detail 1888 Not Applicable  
polypeptide OTTMUSP00000007962 VEGA | MGI Sequence Detail 425 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    114 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 379
    Genomic 11
    cDNA 367
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1110, MGD-MRK-1154, MGI:2140117
References
more
  • Summaries
    All 77
    Developmental Gene Expression 14
    Gene Ontology 8
    Phenotypes 22
  • Earliest
    J:2265 Jiang HP, et al., Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7856-60
  • Latest
    J:228894 Coles GL, et al., KIF7 Controls the Proliferation of Cells of the Respiratory Airway through Distinct Microtubule Dependent Mechanisms. PLoS Genet. 2015 Oct;11(10):e1005525

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory