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Plin2 Gene Detail
Summary
  • Symbol
    Plin2
  • Name
    perilipin 2
  • Synonyms
    Adfp, adipophilin, ADPH, Adrp
  • Feature Type
    protein coding gene
  • IDs
    MGI:87920
    NCBI Gene: 11520
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:86648386-86670060 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21675 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 40.69 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    PLIN2, perilipin 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PLIN2, perilipin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADFP, ADRP
  • Links
    NCBI Gene ID: 123
    neXtProt AC: NX_Q99541
    UniProt: Q99541

  • Chr Location
    9p22.1; chr9:19108391-19127606 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 4 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for null mutations are resistant to diet-induced obesity and hepatic steatosis and may exhibit altered milk composition, vision abnormalities, or small sebaceous glands. Male mice homozygous for a gene trap allele are infertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000007453 VEGA Gene Model | MGI Sequence Detail 21675 C57BL/6J ±  kb
    transcript OTTMUST00000017238 VEGA | MGI Sequence Detail 1888 Not Applicable  
    polypeptide OTTMUSP00000007962 VEGA | MGI Sequence Detail 425 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      114 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 380
      Genomic 11
      cDNA 368
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1110, MGD-MRK-1154, MGI:2140117
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 19
      Gene Ontology 9
      Phenotypes 30
    • Earliest
      J:2265 Jiang HP, et al., Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7856-60
    • Latest
      J:265199 Libby AE, et al., Perilipin-2 deletion promotes carbohydrate-mediated browning of white adipose tissue at ambient temperature. J Lipid Res. 2018 Aug;59(8):1482-1500

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory