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Aspa
Gene Detail
Symbol

Name
ID
Aspa
aspartoacylase
MGI:87914
Synonyms
Acy2, Acy-2, aspartoacylase, nur7, small lethargic
Feature Type
protein coding gene
Genetic Map
Chromosome 11
45.28 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:73304992-73329596 bp, - strand
From VEGA annotation of GRCm38

  24605 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:33  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: aspartoacylase
Gene Tree: Aspa

Human
homologs
Human Homolog ASPA, aspartoacylase
NCBI Gene ID 443
neXtProt AC  NX_P45381
Human Synonyms  ACY2, ASP
Human Chr (Location)  17p13.3; chr17:3474110-3499406 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ASPA
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Chemically induced (ENU)(1) Gene trapped(6) Targeted(7)
Incidental mutations (data from APF )
 
Homozygous null mutants have spongy degeneration of the brain, enlarged heads, and decreased life spans and display metal retardation and impaired coordination.
 
Human Diseases Modeled Using Mouse Aspa (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Aspa interacts with 108 markers (Mir1a-1, Mir1a-2, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process acetate metabolic process, metabolic process, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function aminoacylase activity, aspartoacylase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (293)    Tissues (147)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 293
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(24)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006136 (Evidence)
Ensembl Gene ModelENSMUSG00000020774 (Evidence)
Entrez Gene11484 (Evidence)
UniGene293574
DFCITC1581704, TC1660748
DoTSDT.101365366, DT.524018, DT.91383638, DT.94197266
NIA Mouse Gene IndexU033039
EC3.5.1.15
Consensus CDS ProjectCCDS25005.1
International Mouse Knockout Project StatusAspa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006136 VEGA Gene Model | MGI Sequence Detail 24605 C57BL/6J ±  kb
transcript OTTMUST00000013867 VEGA | MGI Sequence Detail 1530 Not Applicable 
polypeptide OTTMUSP00000006437 VEGA | MGI Sequence Detail 312 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(18) UniProt(9)
Polymorphisms
SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016708 Aspartoacylase
InterPro IPR007036 Succinylglutamate desuccinylase/aspartoacylase
Protein Ontology PR:000004378 aspartoacylase
References
(Earliest) J:8672 Nadeau JH, A chromosomal segment conserved since divergence of lineages leading to man and mouse: the gene order of aminoacylase-1, transferrin, and beta-galactosidase on mouse chromosome 9 [published erratum appears in Genet Res 1987 Aug;50(1):77]. Genet Res. 1986 Dec;48(3):175-8
(Latest) J:194259 Lang J, et al., Adenomatous polyposis coli regulates oligodendroglial development. J Neurosci. 2013 Feb 13;33(7):3113-30
All references(55)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-1100, MGD-MRK-1102, MGI:2671359

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory