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Actg1
Gene Detail
Symbol

Name
ID
Actg1
actin, gamma, cytoplasmic 1
MGI:87906
Synonyms
Actl, E51
Feature Type
protein coding gene
Genetic Map
Chromosome 11
84.07 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:120345690-120348542 bp, - strand
From VEGA annotation of GRCm38

  2853 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74402  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: ACTG1
Protein SuperFamily: actin
Gene Tree: Actg1

Human
homologs
ACTG1, actin gamma 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 71
neXtProt AC: NX_P63261

Human Synonyms: ACT, ACTG, BRWS2, DFNA20, DFNA26, HEL-176

Human Chr (Location): 17q25; chr17:81509971-81512866 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human ACTG1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice in which this gene has been conditionally disrupted in muscle tissue display a reduced mobility and classical hind limb contractures when suspended by the tail. Mice homozygous for a null allele exhibit prenatal lethality, premature death, and progressive hearing loss.
 
Phenotype Images(1)
Interactions
Actg1 interacts with 188 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process platelet aggregation, sarcomere organization
Component actin cytoskeleton, blood microparticle, ...
Function ATP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (39)    Tissues (28)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 39
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase actg1    NEW 
Molecular
reagents
All nucleic(30) Genomic(1) cDNA(28) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000004137 (Evidence)
Ensembl Gene Model ENSMUSG00000062825 (Evidence)
Entrez Gene 11465 (Evidence)
DFCI TC1573610
DoTS DT.101200000, DT.101335667, DT.101365895, DT.103564073, DT.87075159, DT.91355621, DT.94160444, DT.94160460, DT.94160572
NIA Mouse Gene Index U004569, U058659, U064867, U089984, U098752, U105632, U109044, U112567, U115538, U124461, U124631, U128662, U134801, U151063, U293454, U338552, U340506, U369436
Consensus CDS Project CCDS25730.1
International Mouse Phenotyping Consortium Status Actg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004137 VEGA Gene Model | MGI Sequence Detail 2853 C57BL/6J ±  kb
transcript OTTMUST00000009340 VEGA | MGI Sequence Detail 1952 Not Applicable 
polypeptide OTTMUSP00000004544 VEGA | MGI Sequence Detail 375 Not Applicable 

For the selected sequences
All sequences(120) RefSeq(4) UniProt(9)
Polymorphisms
SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020902 Actin/actin-like conserved site
InterPro IPR004001 Actin, conserved site
InterPro IPR004000 Actin family
Protein Ontology PR:000003680 actin, cytoplasmic 2
References
(Earliest) J:31028 Cleveland DW, et al., Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 1980 May;20(1):95-105
(Latest) J:211364 Yuan B, et al., A Cardiomyocyte-Specific Wdr1 Knockout Demonstrates Essential Functional Roles for Actin Disassembly during Myocardial Growth and Maintenance in Mice. Am J Pathol. 2014 Jul;184(7):1967-80
All references(72)
Other
accession IDs
MGD-MRK-1090, MGD-MRK-38474, MGI:109429, MGI:2144346

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory