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Actg1
Gene Detail
 Symbol
Name
ID
Actg1
actin, gamma, cytoplasmic 1
MGI:87906
Synonyms Actl, E51
Feature Type protein coding gene
Genetic Map
Chromosome 11
84.07 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:120345690-120348542 bp, - strand
From VEGA annotation of GRCm38

  2853 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74402  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 2 zebrafish

Protein SuperFamily: actin
Gene Tree: Actg1

Human
homologs
Human Homolog ACTG1, actin, gamma 1
NCBI Gene ID 71
neXtProt AC  NX_P63261
Human Synonyms  ACT, ACTG, BRWS2, DFNA20, DFNA26, HEL-176
Human Chr (Location)  17q25; chr17:81509971-81512890 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human ACTG1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice in which this gene has been conditionally disrupted in muscle tissue display a reduced mobility and classical hind limb contractures when suspended by the tail. Mice homozygous for a null allele exhibit prenatal lethality, premature death, and progressive hearing loss.
 
Phenotype Images(1)
Interactions
Actg1 interacts with 189 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process sarcomere organization
Component actin cytoskeleton, blood microparticle, ...
Function ATP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (39)    Tissues (28)    Images (10)
Theiler Stages: 19, 22, 23, 24, 28
Assay TypeResults
RNA in situ 39
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(1) cDNA(28) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000004137 (Evidence)
Ensembl Gene ModelENSMUSG00000062825 (Evidence)
Entrez Gene11465 (Evidence)
DFCITC1573610
DoTSDT.101200000, DT.101335667, DT.101365895, DT.103564073, DT.87075159, DT.91355621, DT.94160444, DT.94160460, DT.94160572
NIA Mouse Gene IndexU004569, U058659, U064867, U089984, U098752, U105632, U109044, U112567, U115538, U124461, U124631, U128662, U134801, U151063, U293454, U338552, U340506, U369436
Consensus CDS ProjectCCDS25730.1
International Mouse Knockout Project StatusActg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004137 VEGA Gene Model | MGI Sequence Detail 2853 C57BL/6J ±  kb
transcript OTTMUST00000009340 VEGA | MGI Sequence Detail 1952 Not Applicable 
polypeptide OTTMUSP00000004544 VEGA | MGI Sequence Detail 375 Not Applicable 

For the selected sequences
All sequences(110) RefSeq(2) UniProt(9)
Polymorphisms SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020902 Actin/actin-like conserved site
InterPro IPR004001 Actin, conserved site
InterPro IPR004000 Actin-related protein
Protein Ontology PR:000003680 actin, cytoplasmic 2
References (Earliest) J:31028 Cleveland DW, et al., Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 1980 May;20(1):95-105
(Latest) J:204328 Tondeleir D, et al., Beta-Actin Is Involved in Modulating Erythropoiesis during Development by Fine-Tuning Gata2 Expression Levels. PLoS One. 2013;8(6):e67855
All references(69)
Other
accession IDs
MGD-MRK-1090, MGD-MRK-38474, MGI:109429, MGI:2144346

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory