Actg1
Gene Detail

Symbol Name ID

Actg1 actin, gamma, cytoplasmic 1 MGI:87906

Synonyms

Actl, E51

Feature Type

protein coding gene

Genetic Map

Chromosome 11

84.07 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:120345690-120348542 bp, - strand From VEGA annotation of GRCm38   2853 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74402  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Actg1

Human homologs

Human Homolog		ACTG1, actin, gamma 1
NCBI Gene ID		71
neXtProt AC		NX_P63261
Human Synonyms		ACT, ACTG, BRWS2, DFNA20, DFNA26
Human Chr (Location)		17q25; chr17:79476997-79479892 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ACTG1

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice in which this gene has been conditionally disrupted in muscle tissue display a reduced mobility and classical hind limb contractures when suspended by the tail. Mice homozygous for a null allele exhibit prenatal lethality, premature death, and progressive hearing loss.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	sarcomere organization
Component	actin cytoskeleton, costamere, ...
Function	ATP binding, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (39)    Tissues (28)    Images (10)
Theiler Stages: 19, 22, 23, 24, 28

Assay Type	Results
RNA in situ	39

cDNA source data(28)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) Genomic(1) cDNA(28) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000004137 (Evidence)
Ensembl Gene Model	ENSMUSG00000062825 (Evidence)
Entrez Gene	11465 (Evidence)
DFCI	TC1573610
DoTS	DT.101200000, DT.101335667, DT.101365895, DT.103564073, DT.87075159, DT.91355621, DT.94160444, DT.94160460, DT.94160572
NIA Mouse Gene Index	U004569, U058659, U064867, U089984, U098752, U105632, U109044, U112567, U115538, U124461, U124631, U128662, U134801, U151063, U293454, U338552, U340506, U369436
Consensus CDS Project	CCDS25730.1
International Mouse Knockout Project Status	Actg1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000004137	VEGA Gene Model | MGI Sequence Detail	2853	C57BL/6J
transcript	OTTMUST00000009340	VEGA | MGI Sequence Detail	1952	Not Applicable
polypeptide	OTTMUSP00000004544	VEGA | MGI Sequence Detail	375	Not Applicable

All sequences(108) RefSeq(2) UniProt(9)

Polymorphisms

SNPs(1 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020902	Actin/actin-like conserved site
InterPro	IPR004001	Actin, conserved site
InterPro	IPR004000	Actin-like
Protein Ontology	PR:000003680	actin, cytoplasmic 2

References

(Earliest) J:31028 Cleveland DW, et al., Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 1980 May;20(1):95-105
(Latest) J:185044 Rullo J, et al., Actin polymerization stabilizes alpha4beta1 integrin anchors that mediate monocyte adhesion. J Cell Biol. 2012 Apr 2;197(1):115-29
All references(66)

Other accession IDs

MGD-MRK-1090, MGD-MRK-38474, MGI:109429, MGI:2144346