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Actg1
Gene Detail
Symbol

Name
ID
Actg1
actin, gamma, cytoplasmic 1
MGI:87906
Synonyms
Actl, E51
Feature Type
protein coding gene
Genetic Map
Chromosome 11
84.07 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:120345690-120348542 bp, - strand
From VEGA annotation of GRCm38

  2853 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74402  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: actin
Gene Tree: Actg1

Human
homologs
Human Homolog ACTG1, actin, gamma 1
NCBI Gene ID 71
neXtProt AC  NX_P63261
Human Synonyms  ACT, ACTG, BRWS2, DFNA20, DFNA26, HEL-176
Human Chr (Location)  17q25; chr17:81509971-81512890 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human ACTG1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice in which this gene has been conditionally disrupted in muscle tissue display a reduced mobility and classical hind limb contractures when suspended by the tail. Mice homozygous for a null allele exhibit prenatal lethality, premature death, and progressive hearing loss.
 
Phenotype Images(1)
Interactions
Actg1 interacts with 189 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process platelet aggregation, sarcomere organization
Component actin cytoskeleton, blood microparticle, ...
Function ATP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (39)    Tissues (28)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 39
cDNA source data(28)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) Genomic(1) cDNA(28) Other(1)
Microarray probesets(6)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004137 VEGA Gene Model | MGI Sequence Detail 2853 C57BL/6J ±  kb
transcript OTTMUST00000009340 VEGA | MGI Sequence Detail 1952 Not Applicable 
polypeptide OTTMUSP00000004544 VEGA | MGI Sequence Detail 375 Not Applicable 

For the selected sequences
All sequences(118) RefSeq(2) UniProt(17)
Polymorphisms
SNPs within 2kb(1 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020902 Actin/actin-like conserved site
InterPro IPR004001 Actin, conserved site
InterPro IPR004000 Actin-related protein
Protein Ontology PR:000003680 actin, cytoplasmic 2
References
(Earliest) J:31028 Cleveland DW, et al., Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 1980 May;20(1):95-105
(Latest) J:209602 Li CL, et al., SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons. J Neurosci. 2014 Mar 12;34(11):4027-42
All references(71)
Other
accession IDs
MGD-MRK-1090, MGD-MRK-38474, MGI:109429, MGI:2144346

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory