Actc1
Gene Detail

Symbol Name ID

Actc1 actin, alpha, cardiac muscle 1 MGI:87905

Synonyms

Actc-1, alphac-actin

Feature Type

protein coding gene

Genetic Map

Chromosome 2

57.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)

Sequence Map

Chr2:114047282-114053548 bp, - strand From VEGA annotation of GRCm38   6267 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68446  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Actc1

Human homologs

Human Homolog		ACTC1, actin, alpha, cardiac muscle 1
NCBI Gene ID		70
neXtProt AC		NX_P68032
Human Synonyms		ACTC, ASD5, CMD1R, CMH11, LVNC4
Human Chr (Location)		15q14; chr15:35080297-35087927 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human ACTC1

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous null mutation of this gene results in embryonic and postnatal lethality. Animals that survive to birth die within the first 2 weeks and display reduced body size and heart muscle defects.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	actin filament-based movement, actin-myosin filament sliding, ...
Component	actin filament, actomyosin, actin part, ...
Function	ATPase activity, ATP binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (105 records)
Data Summary: Results (395)    Tissues (298)    Images (125)
Theiler Stages: 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	12
RNA in situ	342
Northern blot	4
RT-PCR	37

cDNA source data(357)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(373) Genomic(4) cDNA(361) Primer pair(7) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000015175 (Evidence)
Ensembl Gene Model	ENSMUSG00000068614 (Evidence)
Entrez Gene	11464 (Evidence)
UniGene	686
DFCI	TC1573851
DoTS	DT.87078535, DT.91294559
NIA Mouse Gene Index	U023182
Consensus CDS Project	CCDS16564.1
International Mouse Knockout Project Status	Actc1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015175	VEGA Gene Model | MGI Sequence Detail	6267	C57BL/6J
transcript	OTTMUST00000035992	VEGA | MGI Sequence Detail	1473	Not Applicable
polypeptide	OTTMUSP00000016161	VEGA | MGI Sequence Detail	377	Not Applicable

All sequences(43) RefSeq(2) UniProt(7)

Polymorphisms

RFLP(9) : SNPs(69 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020902	Actin/actin-like conserved site
InterPro	IPR004001	Actin, conserved site
InterPro	IPR004000	Actin-related protein
Protein Ontology	PR:000003679	actin, alpha cardiac muscle 1

References

(Earliest) J:32044 Minty AJ, et al., A fetal skeletal muscle actin mRNA in the mouse and its identity with cardiac actin mRNA. Cell. 1982 Aug;30(1):185-92
(Latest) J:194471 Borensztein M, et al., Myod and H19-Igf2 locus interactions are required for diaphragm formation in the mouse. Development. 2013 Mar;140(6):1231-9
All references(166)

Other accession IDs

MGD-MRK-1088, MGD-MRK-1089