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Actc1
Gene Detail
Symbol

Name
ID
Actc1
actin, alpha, cardiac muscle 1
MGI:87905
Synonyms
Actc-1, alphac-actin
Feature Type
protein coding gene
Genetic Map
Chromosome 2
57.55 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr2:114047282-114053548 bp, - strand
From VEGA annotation of GRCm38

  6267 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68446  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 4 zebrafish

HCOP human homology predictions: ACTC1
Protein SuperFamily: actin
Gene Tree: Actc1

Human
homologs
ACTC1, actin, alpha, cardiac muscle 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 70
neXtProt AC: NX_P68032

Human Synonyms: ACTC, ASD5, CMD1R, CMH11, LVNC4

Human Chr (Location): 15q14; chr15:34788096-34795726 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human ACTC1

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(5) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutation of this gene results in embryonic and postnatal lethality. Animals that survive to birth die within the first 2 weeks and display reduced body size and heart muscle defects.
 
Human Diseases Modeled in Mice Using Actc1 (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Actc1 interacts with 67 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process actin filament-based movement, actin-mediated cell contraction, ...
Component actin filament, actomyosin, actin portion, ...
Function ATPase activity, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (115 records)
Data Summary: Results (463)    Tissues (346)    Images (138)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 22
RNA in situ 400
Northern blot 4
RT-PCR 37
cDNA source data(362)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ACTC1 ; Xenbase actc1 ; ZFIN actc1a, actc1b    NEW 
Molecular
reagents
All nucleic(378) Genomic(4) cDNA(366) Primer pair(7) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000015175 (Evidence)
Ensembl Gene Model ENSMUSG00000068614 (Evidence)
Entrez Gene 11464 (Evidence)
UniGene 686
DFCI TC1573851
DoTS DT.87078535, DT.91294559
NIA Mouse Gene Index U023182
Consensus CDS Project CCDS16564.1
International Mouse Phenotyping Consortium Status Actc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015175 VEGA Gene Model | MGI Sequence Detail 6267 C57BL/6J ±  kb
transcript OTTMUST00000035992 VEGA | MGI Sequence Detail 1473 Not Applicable 
polypeptide OTTMUSP00000016161 VEGA | MGI Sequence Detail 377 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(7)
Polymorphisms
RFLP(9) : SNPs within 2kb(102 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020902 Actin/actin-like conserved site
InterPro IPR004001 Actin, conserved site
InterPro IPR004000 Actin-related protein
Protein Ontology PR:000003679 actin, alpha cardiac muscle 1
References
(Earliest) J:32044 Minty AJ, et al., A fetal skeletal muscle actin mRNA in the mouse and its identity with cardiac actin mRNA. Cell. 1982 Aug;30(1):185-92
(Latest) J:217656 Lescroart F, et al., Clonal analysis reveals a common origin between nonsomite-derived neck muscles and heart myocardium. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1446-51
All references(175)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1088, MGD-MRK-1089

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory