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Chrng
Gene Detail
 Symbol
Name
ID
Chrng
cholinergic receptor, nicotinic, gamma polypeptide
MGI:87895
STS D1Mit49, D1Mit51
Synonyms Achr-3, Acrg
Feature Type protein coding gene
Genetic Map
Chromosome 1
44.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(46)
Sequence Map
Chr1:87205811-87211835 bp, + strand
From NCBI annotation of GRCm38

  6025 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3810  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Chrng

Human
homologs
Human Homolog CHRNG, cholinergic receptor, nicotinic, gamma (muscle)
NCBI Gene ID 1146
neXtProt AC  NX_P07510
Human Synonyms  ACHRG
Human Chr (Location)  2q37.1; chr2:232539727-232546328 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human CHRNG
Alleles
and
phenotypes
All alleles(7) : Targeted(6) Gene trapped(1)
 
Homozygous null mice display perinatal and postnatal lethality, paradoxical breathing, abnormal skeletal muscle morphology, abnormal neuromuscular junction morphology and physiology, and are unable to suckle.
 
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cation transport, ion transmembrane transport, ...
Component acetylcholine-gated channel complex, cell junction, ...
Function acetylcholine-activated cation-selective channel activity, extracellular ligand-gated ion channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (137)    Tissues (36)    Images (23)
Theiler Stages: 18, 21, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 119
Northern blot 3
RT-PCR 15
cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(45) Genomic(7) cDNA(28) Primer pair(6) Other(4)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000026253 (Evidence)
Entrez Gene11449 (Evidence)
UniGene2810
DFCITC1585048, TC1615811
DoTSDT.102555570, DT.536491
NIA Mouse Gene IndexU000553
Consensus CDS ProjectCCDS35651.1
International Mouse Knockout Project StatusChrng
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11449 NCBI Gene Model | MGI Sequence Detail 6025 C57BL/6J ±  kb
transcript NM_009604 RefSeq | MGI Sequence Detail 1921 C57BL/6 
polypeptide P04760 UniProt | EBI | MGI Sequence Detail 519 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(5)
Polymorphisms All PCR and RFLP(15) : PCR(3) RFLP(12) SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
InterPro IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
InterPro IPR002394 Nicotinic acetylcholine receptor
Protein Ontology PR:000005468 acetylcholine receptor subunit gamma
Graphical View of Protein Domain Structure
References (Earliest) J:8277 Yu L, et al., Mouse muscle nicotinic acetylcholine receptor gamma subunit: cDNA sequence and gene expression. Nucleic Acids Res. 1986 Apr 25;14(8):3539-55
(Latest) J:200692 Nayak TK, et al., Asymmetric transmitter binding sites of fetal muscle acetylcholine receptors shape their synaptic response. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13654-9
All references(105)
Other
accession IDs
MGD-MRK-1038, MGD-MRK-1070

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory