Chrng
Gene Detail

Symbol Name ID

Chrng cholinergic receptor, nicotinic, gamma polypeptide MGI:87895

STS

D1Mit49, D1Mit51

Synonyms

Achr-3, Acrg

Feature Type

protein coding gene

Genetic Map

Chromosome 1

44.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(46)

Sequence Map

Chr1:87205811-87211835 bp, + strand From NCBI annotation of GRCm38   6025 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3810  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Chrng

Human homologs

Human Homolog		CHRNG, cholinergic receptor, nicotinic, gamma (muscle)
NCBI Gene ID		1146
neXtProt AC		NX_P07510
Human Synonyms		ACHRG
Human Chr (Location)		2q37.1; chr2:233404437-233411038 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human CHRNG

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Homozygous null mice display perinatal and postnatal lethality, paradoxical breathing, abnormal skeletal muscle morphology, abnormal neuromuscular junction morphology and physiology, and are unable to suckle.

 

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	cation transport, ion transmembrane transport, ...
Component	acetylcholine-gated channel complex, cell junction, ...
Function	acetylcholine-activated cation-selective channel activity, extracellular ligand-gated ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (137)    Tissues (36)    Images (23)
Theiler Stages: 18, 21, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	119
Northern blot	3
RT-PCR	15

cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(45) Genomic(7) cDNA(28) Primer pair(6) Other(4)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000026253 (Evidence)
Entrez Gene	11449 (Evidence)
UniGene	2810
DFCI	TC1585048, TC1615811
DoTS	DT.102555570, DT.536491
NIA Mouse Gene Index	U000553
Consensus CDS Project	CCDS35651.1
International Mouse Knockout Project Status	Chrng

Sequences

Length	Strain/Species
genomic	11449	NCBI Gene Model | MGI Sequence Detail	6025	C57BL/6J
transcript	NM_009604	RefSeq | MGI Sequence Detail	1921	C57BL/6
polypeptide	P04760	UniProt | EBI | MGI Sequence Detail	519	Not Applicable

All sequences(27) RefSeq(2) UniProt(5)

Polymorphisms

All PCR and RFLP(15) : PCR(3) RFLP(12) SNPs(47 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006201	Neurotransmitter-gated ion-channel
InterPro	IPR018000	Neurotransmitter-gated ion-channel, conserved site
InterPro	IPR006202	Neurotransmitter-gated ion-channel ligand-binding
InterPro	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
InterPro	IPR002394	Nicotinic acetylcholine receptor
Protein Ontology	PR:000005468	acetylcholine receptor subunit gamma

Graphical View of Protein Domain Structure

References

(Earliest) J:8277 Yu L, et al., Mouse muscle nicotinic acetylcholine receptor gamma subunit: cDNA sequence and gene expression. Nucleic Acids Res. 1986 Apr 25;14(8):3539-55
(Latest) J:183613 Gonzalez-Gutierrez G, et al., Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6331-6
All references(104)

Other accession IDs

MGD-MRK-1038, MGD-MRK-1070