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Chrng Gene Detail
Summary
  • Symbol
    Chrng
  • Name
    cholinergic receptor, nicotinic, gamma polypeptide
  • Synonyms
    Achr-3, Acrg
  • Feature Type
    protein coding gene
  • IDs
    MGI:87895
    NCBI Gene: 11449
  • Gene Overview
    MyGene.info: CHRNG
Location & Maps
more
  • Sequence Map
    Chr1:87204657-87212694 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8038 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 44.07 cM
  • Mapping Data
    47 experiments
  • Sequence Tags
Homology
more
  • Human Ortholog
    CHRNG, cholinergic receptor nicotinic gamma subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CHRNG, cholinergic receptor nicotinic gamma subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACHRG
  • Links
    NCBI Gene ID: 1146
    neXtProt AC: NX_P07510

  • Chr Location
    2q37.1; chr2:232539727-232546328 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3810
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CHRNG
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human CHRNG associations

Human Disease Mouse Models
       Multiple Pterygium Syndrome, Escobar Variant; EVMPS   OMIM: 265000
Multiple Pterygium Syndrome, Lethal Type; LMPS   OMIM: 253290
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 4 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Chrng
  • Incidental Mutations
Homozygous null mice display perinatal and postnatal lethality, paradoxical breathing, abnormal skeletal muscle morphology, abnormal neuromuscular junction morphology and physiology, and are unable to suckle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048193 VEGA Gene Model | MGI Sequence Detail 8038 C57BL/6J ±  kb
transcript OTTMUST00000123733 VEGA | MGI Sequence Detail 2780 Not Applicable  
polypeptide OTTMUSP00000067488 VEGA | MGI Sequence Detail 519 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    71 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000005468 acetylcholine receptor subunit gamma
  • InterPro Domains
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
    IPR002394 Nicotinic acetylcholine receptor
Molecular
Reagents
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  • All nucleic 46
    Genomic 7
    cDNA 29
    Primer pair 6
    Other 4

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-1038, MGD-MRK-1070
References
more
  • Summaries
    All 103
    Developmental Gene Expression 15
    Gene Ontology 8
    Phenotypes 12
  • Earliest
    J:8277 Yu L, et al., Mouse muscle nicotinic acetylcholine receptor gamma subunit: cDNA sequence and gene expression. Nucleic Acids Res. 1986 Apr 25;14(8):3539-55
  • Latest
    J:221937 Watson JA, et al., Motor and Sensory Deficits in the teetering Mice Result from Mutation of the ESCRT Component HGS. PLoS Genet. 2015 Jun;11(6):e1005290

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory