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Chrng
Gene Detail
Symbol

Name
ID
Chrng
cholinergic receptor, nicotinic, gamma polypeptide
MGI:87895
Synonyms
Achr-3, Acrg
Feature Type
protein coding gene
Genetic Map
Chromosome 1
44.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(46)
Sequence Map
Chr1:87204657-87212694 bp, + strand
From VEGA annotation of GRCm38

  8038 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3810  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Chrng

Human
homologs
Human Homolog CHRNG, cholinergic receptor, nicotinic, gamma (muscle)
NCBI Gene ID 1146
neXtProt AC  NX_P07510
Human Synonyms  ACHRG
Human Chr (Location)  2q37.1; chr2:232539727-232546328 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human CHRNG
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display perinatal and postnatal lethality, paradoxical breathing, abnormal skeletal muscle morphology, abnormal neuromuscular junction morphology and physiology, and are unable to suckle.
 
Interactions
Chrng interacts with 75 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (14 records)
Data Summary: Results (137)    Tissues (36)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 119
Northern blot 3
RT-PCR 15
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) Genomic(7) cDNA(28) Primer pair(6) Other(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000048193 (Evidence)
Ensembl Gene ModelENSMUSG00000026253 (Evidence)
Entrez Gene11449 (Evidence)
UniGene2810
DFCITC1585048, TC1615811
DoTSDT.102555570, DT.536491
NIA Mouse Gene IndexU000553
Consensus CDS ProjectCCDS35651.1
International Mouse Knockout Project StatusChrng
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048193 VEGA Gene Model | MGI Sequence Detail 8038 C57BL/6J ±  kb
transcript OTTMUST00000123733 VEGA | MGI Sequence Detail 2780 Not Applicable 
polypeptide OTTMUSP00000067488 VEGA | MGI Sequence Detail 519 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(10)
Polymorphisms
All PCR and RFLP(15) : PCR(3) RFLP(12) SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
InterPro IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
InterPro IPR002394 Nicotinic acetylcholine receptor
Protein Ontology PR:000005468 acetylcholine receptor subunit gamma
References
(Earliest) J:8277 Yu L, et al., Mouse muscle nicotinic acetylcholine receptor gamma subunit: cDNA sequence and gene expression. Nucleic Acids Res. 1986 Apr 25;14(8):3539-55
(Latest) J:200692 Nayak TK, et al., Asymmetric transmitter binding sites of fetal muscle acetylcholine receptors shape their synaptic response. Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13654-9
All references(106)
Other
accession IDs
MGD-MRK-1038, MGD-MRK-1070

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory