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Chrng Gene Detail
Summary
  • Symbol
    Chrng
  • Name
    cholinergic receptor, nicotinic, gamma polypeptide
  • Synonyms
    Achr-3, Acrg
  • Feature Type
    protein coding gene
  • IDs
    MGI:87895
    NCBI Gene: 11449
  • Gene Overview
    MyGene.info: CHRNG
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:87205811-87211835 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 44.07 cM
  • Mapping Data
    47 experiments
  • Sequence Tags
Strain
Comparison
more
  • SNPs within 2kb
    60 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87895
protein coding gene Chr1:87204657-87212694 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016260
protein coding gene Chr1:88542109-88550175 (+)
A/J MGP_AJ_G0016241
protein coding gene Chr1:85233762-85241791 (+)
AKR/J MGP_AKRJ_G0016202
protein coding gene Chr1:87750600-87758637 (+)
BALB/cJ MGP_BALBcJ_G0016198
protein coding gene Chr1:85356196-85364516 (+)
C3H/HeJ MGP_C3HHeJ_G0016026
protein coding gene Chr1:88010077-88019140 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016654
protein coding gene Chr1:91880402-91888439 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014376
protein coding gene Chr1:79682720-79690756 (+)
CAST/EiJ MGP_CASTEiJ_G0015611
protein coding gene Chr1:87213358-87221685 (+)
CBA/J MGP_CBAJ_G0016002
protein coding gene Chr1:94750402-94758412 (+)
DBA/2J MGP_DBA2J_G0016105
protein coding gene Chr1:84539615-84547865 (+)
FVB/NJ MGP_FVBNJ_G0016104
protein coding gene Chr1:83598404-83606414 (+)
LP/J MGP_LPJ_G0016176
protein coding gene Chr1:89605223-89614477 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016130
protein coding gene Chr1:98042556-98051957 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016697
protein coding gene Chr1:87851524-87862903 (+)
PWK/PhJ MGP_PWKPhJ_G0015398
protein coding gene Chr1:83835063-83843636 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015178
protein coding gene Chr1:86774906-86782936 (+)
WSB/EiJ MGP_WSBEiJ_G0015675
protein coding gene Chr1:87523214-87531226 (+)



Homology
more
  • Human Ortholog
    CHRNG, cholinergic receptor nicotinic gamma subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CHRNG, cholinergic receptor nicotinic gamma subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACHRG
  • Links
    NCBI Gene ID: 1146
    neXtProt AC: NX_P07510
    UniProt: P07510

  • Chr Location
    2q37.1; chr2:232539727-232546328 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3810
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CHRNG
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CHRNG associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 4 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display perinatal and postnatal lethality, paradoxical breathing, abnormal skeletal muscle morphology, abnormal neuromuscular junction morphology and physiology, and are unable to suckle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11449 NCBI Gene Model | MGI Sequence Detail 6025 C57BL/6J ±  kb
    transcript NM_009604 RefSeq | MGI Sequence Detail 1921 C57BL/6  
    polypeptide P04760 UniProt | EBI | MGI Sequence Detail 519 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
      IPR002394 Nicotinic acetylcholine receptor
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 7
      cDNA 30
      Primer pair 6
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1038, MGD-MRK-1070
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 17
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:239493 Sigoillot SM, et al., Neuromuscular junction immaturity and muscle atrophy are hallmarks of the ColQ-deficient mouse, a model of congenital myasthenic syndrome with acetylcholinesterase deficiency. FASEB J. 2016 Jun;30(6):2382-99

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory