Chrna1
Gene Detail

Symbol Name ID

Chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) MGI:87885

Synonyms

Achr-1, Acra

Feature Type

protein coding gene

Genetic Map

Chromosome 2

43.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(50)

Sequence Map

Chr2:73563215-73580338 bp, - strand From VEGA annotation of GRCm38   17124 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:59  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Chrna1

Human homologs

Human Homolog		CHRNA1, cholinergic receptor, nicotinic, alpha 1 (muscle)
NCBI Gene ID		1134
neXtProt AC		NX_P02708
Human Synonyms		ACHRA, ACHRD, CHRNA, CMS2A, FCCMS, SCCMS
Human Chr (Location)		2q31.1; chr2:175612320-175629200 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human CHRNA1

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Mice homozygous for a knock-out allele exhibit neonatal lethality, kyphosis, carpotosis, absent miniature and nerve-evoked endplant potential, increased motor neuron number, and abnormal neuromuscular synapse.

 

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	cation transport, ion transmembrane transport, ...
Component	acetylcholine-gated channel complex, cell junction, ...
Function	acetylcholine-activated cation-selective channel activity, acetylcholine binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (31 records)
Data Summary: Results (114)    Tissues (20)    Images (25)
Theiler Stages: 18, 21, 22, 23, 25, 26, 28

Assay Type	Results
RNA in situ	90
Northern blot	3
RT-PCR	15
RNase protection	6

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(38) cDNA(34) Primer pair(1) Other(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000013434 (Evidence)
Ensembl Gene Model	ENSMUSG00000027107 (Evidence)
Entrez Gene	11435 (Evidence)
UniGene	4583
DFCI	TC1582446, TC1665985
DoTS	DT.484075
NIA Mouse Gene Index	U022747
PDB	2QC1
Consensus CDS Project	CCDS16132.1
International Mouse Knockout Project Status	Chrna1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013434	VEGA Gene Model | MGI Sequence Detail	17124	C57BL/6J
transcript	OTTMUST00000032468	VEGA | MGI Sequence Detail	4386	Not Applicable
polypeptide	OTTMUSP00000014418	VEGA | MGI Sequence Detail	457	Not Applicable

All sequences(25) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(14) : SNPs(87 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006201	Neurotransmitter-gated ion-channel
InterPro	IPR018000	Neurotransmitter-gated ion-channel, conserved site
InterPro	IPR006202	Neurotransmitter-gated ion-channel ligand-binding
InterPro	IPR006029	Neurotransmitter-gated ion-channel transmembrane domain
InterPro	IPR002394	Nicotinic acetylcholine receptor
Protein Ontology	PR:000005453	acetylcholine receptor subunit alpha

References

(Earliest) J:32043 Merlie JP, et al., cDNA clone for the alpha subunit of the acetylcholine receptor from the mouse muscle cell line BC3H-1. Proc Natl Acad Sci U S A. 1983 Jun;80(12):3845-9
(Latest) J:185517 Purohit P, et al., Sources of energy for gating by neurotransmitters in acetylcholine receptor channels. Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9384-9
All references(142)

Other accession IDs

MGD-MRK-1036, MGD-MRK-1054, MGI:2138920, MGI:2139021