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Chrna1
Gene Detail
 Symbol
Name
ID
Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
MGI:87885
Synonyms Achr-1, Acra
Feature Type protein coding gene
Genetic Map
Chromosome 2
43.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(50)
Sequence Map
Chr2:73563215-73580338 bp, - strand
From VEGA annotation of GRCm38

  17124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:59  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Chrna1

Human
homologs
Human Homolog CHRNA1, cholinergic receptor, nicotinic, alpha 1 (muscle)
NCBI Gene ID 1134
neXtProt AC  NX_P02708
Human Synonyms  ACHRA, ACHRD, CHRNA, CMS2A, FCCMS, SCCMS
Human Chr (Location)  2q31.1; chr2:174747592-174764472 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human CHRNA1
Alleles
and
phenotypes
All alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit neonatal lethality, kyphosis, carpotosis, absent miniature and nerve-evoked endplant potential, increased motor neuron number, and abnormal neuromuscular synapse.
 
Gene Ontology
(GO)
classifications
All GO classifications: (42 annotations)
Process cation transport, ion transmembrane transport, ...
Component acetylcholine-gated channel complex, cell junction, ...
Function acetylcholine-activated cation-selective channel activity, acetylcholine binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (114)    Tissues (20)    Images (25)
Theiler Stages: 18, 21, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 90
Northern blot 3
RT-PCR 15
RNase protection 6
cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(38) cDNA(34) Primer pair(1) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000013434 (Evidence)
Ensembl Gene ModelENSMUSG00000027107 (Evidence)
Entrez Gene11435 (Evidence)
UniGene4583
DFCITC1582446, TC1665985
DoTSDT.484075
NIA Mouse Gene IndexU022747
PDB2QC1
Consensus CDS ProjectCCDS16132.1
International Mouse Knockout Project StatusChrna1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013434 VEGA Gene Model | MGI Sequence Detail 17124 C57BL/6J ±  kb
transcript OTTMUST00000032468 VEGA | MGI Sequence Detail 4386 Not Applicable 
polypeptide OTTMUSP00000014418 VEGA | MGI Sequence Detail 457 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(4)
Polymorphisms RFLP(14) : SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
InterPro IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
InterPro IPR002394 Nicotinic acetylcholine receptor
Protein Ontology PR:000005453 acetylcholine receptor subunit alpha
References (Earliest) J:32043 Merlie JP, et al., cDNA clone for the alpha subunit of the acetylcholine receptor from the mouse muscle cell line BC3H-1. Proc Natl Acad Sci U S A. 1983 Jun;80(12):3845-9
(Latest) J:198597 Gupta S, et al., Function of interfacial prolines at the transmitter-binding sites of the neuromuscular acetylcholine receptor. J Biol Chem. 2013 May 3;288(18):12667-79
All references(146)
Other
accession IDs
MGD-MRK-1036, MGD-MRK-1054, MGI:2138920, MGI:2139021

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory