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Chrna1
Gene Detail
Symbol

Name
ID
Chrna1
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)
MGI:87885
Synonyms
Achr-1, Acra
Feature Type
protein coding gene
Genetic Map
Chromosome 2
43.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(50)
Sequence Map
Chr2:73563215-73580338 bp, - strand
From VEGA annotation of GRCm38

  17124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:59  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CHRNA1
Gene Tree: Chrna1

Human
homologs
CHRNA1, cholinergic receptor, nicotinic, alpha 1 (muscle)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1134
neXtProt AC: NX_P02708

Human Synonyms: ACHRA, ACHRD, CHRNA, CMS1A, CMS1B, CMS2A, FCCMS, SCCMS

Human Chr (Location): 2q31.1; chr2:174747592-174764472 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human CHRNA1

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Targeted(9)
Genomic Mutations involving Chrna1 (5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit neonatal lethality, kyphosis, carpotosis, absent miniature and nerve-evoked endplant potential, increased motor neuron number, and abnormal neuromuscular synapse.
 
Phenotype Images(1)
Interactions
Chrna1 interacts with 312 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (32 records)
Data Summary: Results (114)    Tissues (20)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 90
Northern blot 3
RT-PCR 15
RNase protection 6
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CHRNA1 ; Xenbase chrna1, chrna1.2 ; ZFIN chrna1    NEW 
Molecular
reagents
All nucleic(37) cDNA(33) Primer pair(1) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000013434 (Evidence)
Ensembl Gene Model ENSMUSG00000027107 (Evidence)
Entrez Gene 11435 (Evidence)
UniGene 4583
DFCI TC1582446, TC1665985
DoTS DT.484075
NIA Mouse Gene Index U022747
PDB 2QC1
Consensus CDS Project CCDS16132.1
International Mouse Phenotyping Consortium Status Chrna1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013434 VEGA Gene Model | MGI Sequence Detail 17124 C57BL/6J ±  kb
transcript OTTMUST00000032468 VEGA | MGI Sequence Detail 4386 Not Applicable 
polypeptide OTTMUSP00000014418 VEGA | MGI Sequence Detail 457 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(14) : SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006201 Neurotransmitter-gated ion-channel
InterPro IPR018000 Neurotransmitter-gated ion-channel, conserved site
InterPro IPR006202 Neurotransmitter-gated ion-channel ligand-binding
InterPro IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
InterPro IPR027361 Nicotinic acetylcholine-gated receptor, transmembrane domain
InterPro IPR002394 Nicotinic acetylcholine receptor
Protein Ontology PR:000005453 acetylcholine receptor subunit alpha
References
(Earliest) J:32043 Merlie JP, et al., cDNA clone for the alpha subunit of the acetylcholine receptor from the mouse muscle cell line BC3H-1. Proc Natl Acad Sci U S A. 1983 Jun;80(12):3845-9
(Latest) J:216752 Tezuka T, et al., The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses. Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16556-61
All references(147)
Other
accession IDs
MGD-MRK-1036, MGD-MRK-1054, MGI:2138920, MGI:2139021

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory