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Acp5
Gene Detail
Symbol

Name
ID
Acp5
acid phosphatase 5, tartrate resistant
MGI:87883
STS
Synonyms
TRACP, TRAP
Feature Type
protein coding gene
Genetic Map
Chromosome 9
8.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:22126731-22135746 bp, - strand
From Ensembl annotation of GRCm38

  9016 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:137203  Vertebrate Homology Class
1 mouse; 1 rat

HCOP human homology predictions: ACP5
Protein SuperFamily: acid phosphatase, type 5
Gene Tree: Acp5

Human
homologs
ACP5, acid phosphatase 5, tartrate resistant
Orthology source: HGNC

IDs:
NCBI Gene ID: 54
neXtProt AC: NX_P13686

Human Synonyms: SPENCDI, TRAP

Human Chr (Location): 19p13.2; chr19:11574660-11578986 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ACP5

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(15) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in skeletal defects such as osteopetrosis, and shortening and widening of the bones. Heterozygous mutants display the same phenotype with lesser severity.
 
Interactions
Acp5 interacts with 29 markers (Mir99a, Mir134, Mir137, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process bone morphogenesis, bone resorption, ...
Component lysosome
Function acid phosphatase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (217)    Tissues (128)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 205
RT-PCR 2
cDNA source data(88)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase acp5 ; ZFIN acp5a    NEW 
Molecular
reagents
All nucleic(97) Genomic(5) cDNA(90) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000001348 (Evidence)
Entrez Gene 11433 (Evidence)
UniGene 46354
DFCI TC1574934, TC1687888, TC1702155, TC1776400
DoTS DT.101144293, DT.101387811, DT.101387813, DT.55100487, DT.91418460, DT.97400133
NIA Mouse Gene Index U030604
EC 3.1.3.2
Consensus CDS Project CCDS22923.1
International Mouse Phenotyping Consortium Status Acp5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001348 Ensembl Gene Model | MGI Sequence Detail 9016 C57BL/6J ±  kb
transcript ENSMUST00000115315 Ensembl | MGI Sequence Detail 1349 Not Applicable 
polypeptide ENSMUSP00000110970 Ensembl | MGI Sequence Detail 327 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(14) UniProt(1)
Polymorphisms
SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024927 Acid phosphatase, type 5
InterPro IPR004843 Metallophosphoesterase domain
Protein Ontology PR:000001937 tartrate-resistant acid phosphatase type 5
References
(Earliest) J:4082 Grimes R, et al., Assignment of the mouse tartrate-resistant acid phosphatase gene (Acp5) to chromosome 9. Genomics. 1993 Feb;15(2):421-2
(Latest) J:216100 Akil O, et al., Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia. PLoS One. 2014;9(5):e94989
All references(81)
Other
accession IDs
MGD-MRK-1052

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory