About   Help   FAQ
Acp5 Gene Detail
Summary
  • Symbol
    Acp5
  • Name
    acid phosphatase 5, tartrate resistant
  • Synonyms
    TRACP, TRAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:87883
    NCBI Gene: 11433
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:22126727-22135711 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8985 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 8.38 cM
  • Mapping Data
    4 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    ACP5, acid phosphatase 5, tartrate resistant
  • Vertebrate Orthologs
    2
  • Human Ortholog
    ACP5, acid phosphatase 5, tartrate resistant
    Orthology source: HGNC
  • Synonyms
    HPAP, TRACP5a, TRACP5b, TRAP, TrATPase
  • Links
    NCBI Gene ID: 54
    neXtProt AC: NX_P13686
    UniProt: P13686

  • Chr Location
    19p13.2; chr19:11574660-11579008 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in skeletal defects such as osteopetrosis, and shortening and widening of the bones. Heterozygous mutants display the same phenotype with lesser severity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001348 Ensembl Gene Model | MGI Sequence Detail 8985 C57BL/6J ±  kb
    transcript ENSMUST00000069330 Ensembl | MGI Sequence Detail 1356 Not Applicable  
    polypeptide ENSMUSP00000065425 Ensembl | MGI Sequence Detail 327 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      39 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 99
      Genomic 5
      cDNA 91
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1052
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 41
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:4082 Grimes R, et al., Assignment of the mouse tartrate-resistant acid phosphatase gene (Acp5) to chromosome 9. Genomics. 1993 Feb;15(2):421-2
    • Latest
      J:255349 Rauch F, et al., Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice. Bone. 2018 Feb;107:131-142

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory