Acp5 MGI Mouse Gene Detail - MGI:87883 - acid phosphatase 5, tartrate resistant

Symbol

Acp5
Name

acid phosphatase 5, tartrate resistant
Synonyms

TRACP, TRAP

Feature Type

protein coding gene
IDs

MGI:87883
NCBI Gene: 11433
Alliance

genome feature page
Transcription Start Sites

17 TSS

Sequence Map

Chr9:22038023-22047007 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 8.38 cM
Mapping Data

4 experiments

SNPs within 2kb

395 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_87883	protein coding gene	Chr9:22038023-22047042 (-)
129S1/SvImJ	ENSMUSG00200044612	protein coding gene	Chr9:18992581-19001570 (-)
A/J	ENSMUSG00195038090	protein coding gene	Chr9:18829245-18838234 (-)
AKR/J	ENSMUSG00220027438	protein coding gene	Chr9:18831661-18840647 (-)
BALB/cJ	ENSMUSG00180040285	protein coding gene	Chr9:18963535-18972520 (-)
C3H/HeJ	ENSMUSG00175040292	protein coding gene	Chr9:18926046-18935032 (-)
C57BL/6NJ	ENSMUSG00215029133	protein coding gene	Chr9:18923354-18932338 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031899	protein coding gene	Chr9:18131886-18141195 (-)
CAST/EiJ	ENSTCUG00005026644	protein coding gene	Chr9:18969633-18978589 (-)
CBA/J	ENSMUSG00210043133	protein coding gene	Chr9:18906969-18915956 (-)
DBA/2J	ENSMUSG00185024731	protein coding gene	Chr9:19022274-19031260 (-)
FVB/NJ	ENSMUSG00205032066	protein coding gene	Chr9:19257642-19266689 (-)
JF1/MsJ	ENSUMUG00000035662	protein coding gene	Chr9:19123350-19132403 (-)
LP/J	ENSMUSG00230038607	protein coding gene	Chr9:19416830-19425880 (-)
NOD/ShiLtJ	ENSMUSG00190026937	protein coding gene	Chr9:18950599-18959647 (-)
NZO/HlLtJ	ENSMUSG00225049718	protein coding gene	Chr9:19364213-19373200 (-)
PWK/PhJ	ENSLUMG00010041976	protein coding gene	Chr9:19014342-19023437 (-)
SPRET/EiJ	ENSMSPG00010018702	protein coding gene	Chr9:19237173-19242222 (-)
WSB/EiJ	ENSIUOG00005040573	protein coding gene	Chr9:18492559-18501607 (-)

Human Ortholog

ACP5, acid phosphatase 5, tartrate resistant

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACP5, acid phosphatase 5, tartrate resistant
Synonyms

HPAP, TRAcP, TRACP5a, TRACP5b, TRAP, TrATPase
Links

HGNC:124

NCBI Gene ID: 54

UniProt: P13686
Chr Location

19p13.2; chr19:11574653-11579993 (-) GRCh38

MGI Vertebrate Homology

Acp5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ACP5
Protein SuperFamily

Acid_Ptase_5
Gene Tree

Acp5

Diseases

1 with human ACP5 associations

				Human Disease	Mouse Models
				spondylometaphyseal dysplasia IDs spondylometaphyseal dysplasia DOID:0112295 ORDO:254

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

28 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Endonuclease-mediated

6
Gene trapped

12
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous mutation of this gene results in skeletal defects such as osteopetrosis, and shortening and widening of the bones. Heterozygous mutants display the same phenotype with lesser severity.

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All GO Annotations

40
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

857
Tissues

143
cDNA Data

89
Literature Summary

55

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acp5

ZFIN acp5a

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All Sequences

63
RefSeq

14
UniProt

1
CCDS

CCDS22923.1

Ensembl

ENSMUSG00000001348 (Evidence)
NCBI Gene

11433

			Length	Strain/Species	Flank
genomic	ENSMUSG00000001348	Ensembl Gene Model \| MGI Sequence Detail	8985	C57BL/6J	± kb
transcript	ENSMUST00000217643	Ensembl \| MGI Sequence Detail	1447	Not Applicable
polypeptide	ENSMUSP00000150903	Ensembl \| MGI Sequence Detail	327	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001937 tartrate-resistant acid phosphatase type 5

(term hierarchy)
EC

3.1.3.2
InterPro Domains

IPR004843 Calcineurin-like, phosphoesterase domain

IPR029052 Metallo-dependent phosphatase-like

IPR051558 Metallophosphoesterase Purple Acid Phosphatase

IPR024927 Purple acid phosphatase
GlyGen

Q05117 4 sites, 1 O-linked glycan (1 site)

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All nucleic 105

Genomic 5

cDNA 91

Primer pair 6

Other 3

Antibodies 3

Microarray probesets 4

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MGD-MRK-1052

Summaries

All 199

Developmental Gene Expression 55

Gene Ontology 15

Phenotypes 18
Earliest

J:4082 Grimes R, et al., Assignment of the mouse tartrate-resistant acid phosphatase gene (Acp5) to chromosome 9. Genomics. 1993 Feb;15(2):421-2
Latest

J:391326 Chae SA, et al., Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin-ATF4 Axis. Adv Sci (Weinh). 2026 Aug 7;:e77029

TSS for Acp5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr88476	Chr9:22047067-22047080 (-)	-67 bp
Tssr88475	Chr9:22046971-22047020 (-)	11 bp
Tssr88474	Chr9:22046950-22046961 (-)	51 bp
Tssr88473	Chr9:22043620-22043630 (-)	3,382 bp
Tssr88472	Chr9:22043579-22043596 (-)	3,419 bp
Tssr88471	Chr9:22043553-22043576 (-)	3,442 bp
Tssr88470	Chr9:22043171-22043181 (-)	3,831 bp
Tssr88469	Chr9:22043097-22043170 (-)	3,873 bp
Tssr88468	Chr9:22043063-22043075 (-)	3,938 bp
Tssr88467	Chr9:22042931-22042961 (-)	4,061 bp
Tssr88466	Chr9:22042902-22042916 (-)	4,098 bp
Tssr88465	Chr9:22041907-22041936 (-)	5,085 bp
Tssr88464	Chr9:22041863-22041877 (-)	5,137 bp
Tssr88463	Chr9:22041499-22041509 (-)	5,503 bp
Tssr88462	Chr9:22041437-22041443 (-)	5,567 bp
Tssr88461	Chr9:22041349-22041368 (-)	5,648 bp
Tssr88460	Chr9:22041198-22041232 (-)	5,792 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24