Acp2
Gene Detail

Symbol Name ID

Acp2 acid phosphatase 2, lysosomal MGI:87882

Synonyms

Acp-2, LAP

Feature Type

protein coding gene

Genetic Map

Chromosome 2

50.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:91202885-91214098 bp, + strand From VEGA annotation of GRCm38   11214 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cat, domestic; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Acp2 ± 2 cM)

Protein SuperFamily: acid phosphatase
Gene Tree: Acp2

Human ortholog

ACP2 acid phosphatase 2, lysosomal NCBI Gene ID 53
Human Chr11:47260853-47270457 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human ACP2 (1)

Alleles and phenotypes

All alleles(8) : Targeted(3) Gene trapped(4) Spontaneous(1)
 

Homozygous mutation of this gene result in skeletal defects and a small percentage of mutant animals exhibit tonic-clonic seizures. Mice with a missense mutation (Gly244Glu) are growth retarded and exhibit a disrupted cerebellum cytoarchitecture, an abnormal hair shaft, and skin malformations.

 
Human Diseases Modeled Using Mouse Acp2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	autophagic cell death, dephosphorylation, ...
Component	cytoplasmic vesicle, integral to membrane, ...
Function	acid phosphatase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (207)    Tissues (156)    Images (19)
Theiler Stages: 15, 19, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	183
Northern blot	24

cDNA source data(89)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(91) Genomic(1) cDNA(89) Primer pair(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000014413 (Evidence)
Ensembl Gene Model	ENSMUSG00000002103 (Evidence)
Entrez Gene	11432 (Evidence)
UniGene	45570
DFCI	TC1576732, TC1604835, TC1607760, TC1647765
NIA Mouse Gene Index	U002120, U193476
EC	3.1.3.2
Consensus CDS Project	CCDS16427.1
International Mouse Knockout Project Status	Acp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000014413	VEGA Gene Model | MGI Sequence Detail	11214	C57BL/6J
transcript	OTTMUST00000034159	VEGA | MGI Sequence Detail	4656	Not Applicable
polypeptide	OTTMUSP00000015308	VEGA | MGI Sequence Detail	423	Not Applicable

All sequences(55) RefSeq(2) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(24 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000560	Histidine phosphatase superfamily, clade-2
Protein Ontology	PR:000003647	lysosomal acid phosphatase

References

(Earliest) J:6674 Stallings RL, et al., Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7. Somatic Cell Genet. 1981 Nov;7(6):683-98
(Latest) J:183646 Makrypidi G, et al., Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5. Mol Cell Biol. 2012 Feb;32(4):774-82
All references(52)

Other accession IDs

MGD-MRK-1049, MGD-MRK-1051