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Acp2
Gene Detail
 Symbol
Name
ID
Acp2
acid phosphatase 2, lysosomal
MGI:87882
Synonyms Acp-2, LAP
Feature Type protein coding gene
Genetic Map
Chromosome 2
50.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:91202885-91214098 bp, + strand
From VEGA annotation of GRCm38

  11214 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1217  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: acid phosphatase
Gene Tree: Acp2

Human
homologs
Human Homolog ACP2, acid phosphatase 2, lysosomal
NCBI Gene ID 53
neXtProt AC  NX_P11117
Human Chr (Location)  11p11.2-p11.11; chr11:47239302-47248906 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human ACP2
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Spontaneous(1) Targeted(5)
Genomic Mutations involving Acp2 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene result in skeletal defects and a small percentage of mutant animals exhibit tonic-clonic seizures. Mice with a missense mutation (Gly244Glu) are growth retarded and exhibit a disrupted cerebellum cytoarchitecture, an abnormal hair shaft, and skin malformations.
 
Human Diseases Modeled Using Mouse Acp2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Interactions
Acp2 interacts with 379 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process autophagic cell death, dephosphorylation, ...
Component cytoplasmic vesicle, extracellular vesicular exosome, ...
Function acid phosphatase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (207)    Tissues (156)    Images (19)
Theiler Stages: 15, 19, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 183
Northern blot 24
cDNA source data(90)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(92) Genomic(1) cDNA(90) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000014413 (Evidence)
Ensembl Gene ModelENSMUSG00000002103 (Evidence)
Entrez Gene11432 (Evidence)
UniGene45570
DFCITC1576732, TC1604835, TC1607760, TC1647765
NIA Mouse Gene IndexU002120, U193476
EC3.1.3.2
Consensus CDS ProjectCCDS16427.1
International Mouse Knockout Project StatusAcp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014413 VEGA Gene Model | MGI Sequence Detail 11214 C57BL/6J ±  kb
transcript OTTMUST00000034159 VEGA | MGI Sequence Detail 4656 Not Applicable 
polypeptide OTTMUSP00000015308 VEGA | MGI Sequence Detail 423 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(4) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000560 Histidine phosphatase superfamily, clade-2
Protein Ontology PR:000003647 lysosomal acid phosphatase
References (Earliest) J:6674 Stallings RL, et al., Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7. Somatic Cell Genet. 1981 Nov;7(6):683-98
(Latest) J:202631 Bailey K, et al., Spatial and Temporal Expression of Lysosomal Acid Phosphatase 2 (ACP2) Reveals Dynamic Patterning of the Mouse Cerebellar Cortex. Cerebellum. 2013 Dec;12(6):870-81
All references(54)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1049, MGD-MRK-1051

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory