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Acp1 Gene Detail
Summary
  • Symbol
    Acp1
  • Name
    acid phosphatase 1, soluble
  • Synonyms
    4632432E04Rik, Acp-1, Lmptp, LMW-PTP
  • Feature Type
    protein coding gene
  • IDs
    MGI:87881
    NCBI Gene: 11431
  • Gene Overview
    MyGene.info: ACP1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:30893326-30911589 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18264 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 13.00 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ACP1, acid phosphatase 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    ACP1, acid phosphatase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HAAP, LMWPTP, LMW-PTP
  • Links
    NCBI Gene ID: 52
    neXtProt AC: NX_P24666
    UniProt: P24666

  • Chr Location
    2p25.3; chr2:264869-278283 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show an increased mean serum IL-6 response to LPS challenge. Male homozygotes are smaller than controls whereas female homozygotes show an increased mean skin fibroblast proliferation rate. Males homozygous for a different null allele show decreased response of heart to induced stress.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044573 Ensembl Gene Model | MGI Sequence Detail 18264 C57BL/6J ±  kb
    transcript ENSMUST00000062740 Ensembl | MGI Sequence Detail 3066 Not Applicable  
    polypeptide ENSMUSP00000106509 Ensembl | MGI Sequence Detail 158 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      149 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • PDB
    • EC
    • InterPro Domains
      IPR023485 Phosphotyrosine protein phosphatase I
      IPR036196 Phosphotyrosine protein phosphatase I superfamily
      IPR017867 Protein-tyrosine phosphatase, low molecular weight
      IPR002115 Protein-tyrosine phosphatase, low molecular weight, mammalian
    Molecular
    Reagents
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    • All nucleic 22
      cDNA 21
      Primer pair 1

      Microarray probesets 18
    Other
    Accession IDs
    less
    MGD-MRK-1048, MGD-MRK-1050, MGI:1914786, MGI:2144813
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 7
    • Earliest
      J:5872 Francke U, et al., Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Cytogenet Cell Genet. 1977;19(2-3):57-84
    • Latest
      J:253205 Stanford SM, et al., Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol. 2017 Jun;13(6):624-632

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory