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Acp1
Gene Detail
Symbol

Name
ID
Acp1
acid phosphatase 1, soluble
MGI:87881
Synonyms
4632432E04Rik, Acp-1, LMW-PTP
Feature Type
protein coding gene
Genetic Map
Chromosome 12
13.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr12:30893326-30911612 bp, - strand
From Ensembl annotation of GRCm38

  18287 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38274  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 chicken; 1 zebrafish

HCOP human homology predictions: ACP1
Gene Tree: Acp1

Human
homologs
ACP1, acid phosphatase 1, soluble
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 52
neXtProt AC: NX_P24666

Human Synonyms: HAAP, LMW-PTP

Human Chr (Location): 2p25; chr2:264140-278283 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice show an increased mean serum IL-6 response to LPS challenge. Male homozygous mutant mice are notably smaller than controls adn female mutant mice show an increased mean skin fibroblast proliferation rate.
 
Interactions
Acp1 interacts with 305 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process dephosphorylation, protein dephosphorylation
Component cytoplasm, cytoplasmic side of plasma membrane, ...
Function acid phosphatase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (290)    Tissues (132)    Images (74)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 290
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase acp1 ; ZFIN acp1    NEW 
Molecular
reagents
All nucleic(20) cDNA(20)
Microarray probesets(18)
Other database
links
Ensembl Gene Model ENSMUSG00000044573 (Evidence)
Entrez Gene 11431 (Evidence)
NIA Mouse Gene Index U033875, U051184, U063297, U081947, U097782
EC 3.1.3.2, 3.1.3.48
PDB 2P4U
Consensus CDS Project CCDS36427.1, CCDS49045.1
International Mouse Phenotyping Consortium Status Acp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044573 Ensembl Gene Model | MGI Sequence Detail 18287 C57BL/6J ±  kb
transcript ENSMUST00000062740 Ensembl | MGI Sequence Detail 3107 Not Applicable 
polypeptide ENSMUSP00000106509 Ensembl | MGI Sequence Detail 158 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(5) UniProt(3)
Polymorphisms
SNPs within 2kb(155 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023485 Phosphotyrosine protein phosphatase I superfamily
InterPro IPR000106 Protein-tyrosine phosphatase/arsenate reductase
InterPro IPR017867 Protein-tyrosine phosphatase, low molecular weight
InterPro IPR002115 Protein-tyrosine phosphatase, low molecular weight, mammalian
Protein Ontology PR:000003646 low molecular weight phosphotyrosine protein phosphatase
References
(Earliest) J:5872 Francke U, et al., Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Cytogenet Cell Genet. 1977;19(2-3):57-84
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(38)
Other
accession IDs
MGD-MRK-1048, MGD-MRK-1050, MGI:1914786, MGI:2144813

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory