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Aco2
Gene Detail
Symbol

Name
ID
Aco2
aconitase 2, mitochondrial
MGI:87880
Synonyms
Aco-2, Aco3, D10Wsu183e
Feature Type
protein coding gene
Genetic Map
Chromosome 15
38.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr15:81872309-81915133 bp, + strand
From VEGA annotation of GRCm38

  42825 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:856  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ACO2
Protein SuperFamily: aconitase A/homoaconitase (aconitate hydratase 1)
Gene Tree: Aco2

Human
homologs
ACO2, aconitase 2, mitochondrial
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 50
neXtProt AC: NX_Q99798

Human Synonyms: ACONM, ICRD, OCA8

Human Chr (Location): 22q13.2; chr22:41469125-41528989 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human ACO2

Mutations,
alleles, and
phenotypes
All mutations/alleles(100) : Gene trapped(97) Radiation induced(1) Targeted(2)
Genomic Mutations involving Aco2 (1)
Incidental mutations (data from Mutagenetix , APF )
Phenotype Images(2)
Interactions
Aco2 interacts with 72 markers (Mir7-2, Mir7b, Mir34b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process citrate metabolic process, isocitrate metabolic process, ...
Component mitochondrion, myelin sheath, ...
Function 3 iron, 4 sulfur cluster binding, 4 iron, 4 sulfur cluster binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (363)    Tissues (136)    Images (69)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 357
RT-PCR 6
cDNA source data(18)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase aco2 ; ZFIN aco2    NEW 
Molecular
reagents
All nucleic(22) cDNA(18) Primer pair(3) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000016391 (Evidence)
Ensembl Gene Model ENSMUSG00000022477 (Evidence)
Entrez Gene 11429 (Evidence)
NIA Mouse Gene Index U016471, U158723
EC 4.2.1.3
Consensus CDS Project CCDS27675.1
International Mouse Phenotyping Consortium Status Aco2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016391 VEGA Gene Model | MGI Sequence Detail 42825 C57BL/6J ±  kb
transcript OTTMUST00000039478 VEGA | MGI Sequence Detail 2918 Not Applicable 
polypeptide OTTMUSP00000017637 VEGA | MGI Sequence Detail 780 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(216 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha
InterPro IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
InterPro IPR015932 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2
InterPro IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel
InterPro IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel
InterPro IPR018136 Aconitase family, 4Fe-4S cluster binding site
InterPro IPR015937 Aconitase/isopropylmalate dehydratase
InterPro IPR006248 Aconitase, mitochondrial-like
Protein Ontology PR:000003632 aconitate hydratase, mitochondrial
References
(Earliest) J:13842 Nash HR, et al., Aconitase. Mouse News Lett. 1980;62:57-8
(Latest) J:172853 Kohr MJ, et al., Characterization of potential S-nitrosylation sites in the myocardium. Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1327-35
All references(48)
Other
accession IDs
MGD-MRK-1045, MGD-MRK-1047, MGD-MRK-19418, MGD-MRK-36451, MGI:107874

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory