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Aco2 Gene Detail
Summary
  • Symbol
    Aco2
  • Name
    aconitase 2, mitochondrial
  • Synonyms
    Aco-2, Aco3, D10Wsu183e
  • Feature Type
    protein coding gene
  • IDs
    MGI:87880
    NCBI Gene: 11429
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:81872463-81915137 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 38.26 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    210 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87880
protein coding gene Chr15:81872309-81915137 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022124
protein coding gene Chr15:82343479-82388987 (+)
A/J MGP_AJ_G0022085
protein coding gene Chr15:79436134-79479274 (+)
AKR/J MGP_AKRJ_G0022060
protein coding gene Chr15:81629783-81672534 (+)
BALB/cJ MGP_BALBcJ_G0022091
protein coding gene Chr15:79475748-79518583 (+)
C3H/HeJ MGP_C3HHeJ_G0021862
protein coding gene Chr15:81651652-81698910 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022534
protein coding gene Chr15:85579581-85622675 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020062
protein coding gene Chr15:75883690-75926331 (+)
CAST/EiJ MGP_CASTEiJ_G0021381
protein coding gene Chr15:82430426-82478164 (+)
CBA/J MGP_CBAJ_G0021826
protein coding gene Chr15:88236093-88284220 (+)
DBA/2J MGP_DBA2J_G0021956
protein coding gene Chr15:78908053-78950917 (+)
FVB/NJ MGP_FVBNJ_G0021933
protein coding gene Chr15:77944211-77992047 (+)
LP/J MGP_LPJ_G0022024
protein coding gene Chr15:82490548-82533117 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021954
protein coding gene Chr15:93173395-93216786 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022548
protein coding gene Chr15:81730755-81774824 (+)
PWK/PhJ MGP_PWKPhJ_G0021124
protein coding gene Chr15:78950103-78995471 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020963
protein coding gene Chr15:81520306-81565694 (+)
WSB/EiJ MGP_WSBEiJ_G0021434
protein coding gene Chr15:82146911-82189768 (+)



Homology
more
  • Human Ortholog
    ACO2, aconitase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ACO2, aconitase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACONM, HEL-S-284, ICRD, OCA8, OPA9
  • Links
    NCBI Gene ID: 50
    neXtProt AC: NX_Q99798
    UniProt: Q99798

  • Chr Location
    22q13.2; chr22:41469125-41528989 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ACO2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11429 NCBI Gene Model | MGI Sequence Detail 42675 C57BL/6J ±  kb
transcript NM_080633 RefSeq | MGI Sequence Detail 2785 C57BL/6  
polypeptide Q99KI0 UniProt | EBI | MGI Sequence Detail 780 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000003632 aconitate hydratase, mitochondrial
  • EC
  • InterPro Domains
    IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
    IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
    IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel
    IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
    IPR015932 Aconitase, domain 2
    IPR018136 Aconitase family, 4Fe-4S cluster binding site
    IPR036008 Aconitase, iron-sulfur domain
    IPR006248 Aconitase, mitochondrial-like
Molecular
Reagents
less
  • All nucleic 23
    cDNA 19
    Primer pair 3
    Other 1

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-1045, MGD-MRK-1047, MGD-MRK-19418, MGD-MRK-36451, MGI:107874
References
more
  • Summaries
    All 69
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 11
    Phenotypes 26
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory