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Aco1 Gene Detail
Summary
  • Symbol
    Aco1
  • Name
    aconitase 1
  • Synonyms
    Aco-1, Irebp, Irp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:87879
    NCBI Gene: 11428
Location & Maps
more
  • Sequence Map
    Chr4:40143081-40198338 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      55258 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ACO1, aconitase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACO1, aconitase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1
  • Links
    NCBI Gene ID: 48
    neXtProt AC: NX_P21399

  • Chr Location
    9p21.1; chr9:32384603-32450836 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 5 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically and radiation induced
    1
  • Gene trapped
    5
  • Targeted
    7
  • Genomic Mutations
    1 involving Aco1
  • Incidental Mutations
Mice homozygous for disruptions in this gene display no obvious phenotypic abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006559 VEGA Gene Model | MGI Sequence Detail 55258 C57BL/6J ±  kb
transcript OTTMUST00000014972 VEGA | MGI Sequence Detail 3832 Not Applicable  
polypeptide OTTMUSP00000006919 VEGA | MGI Sequence Detail 889 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    364 from dbSNP Build 137
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000003631 cytoplasmic aconitate hydratase
  • EC
  • InterPro Domains
    IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha domain
    IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
    IPR015932 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2
    IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel
    IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel domain
    IPR018136 Aconitase family, 4Fe-4S cluster binding site
    IPR006249 Aconitase/Iron-responsive element-binding protein 2
    IPR015937 Aconitase/isopropylmalate dehydratase
    IPR029784 Iron regulatory protein 1
Molecular
Reagents
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  • All nucleic 184
    cDNA 182
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-1044, MGD-MRK-1046, MGD-MRK-11463, MGI:2140214
References
more
  • Summaries
    All 70
    Developmental Gene Expression 6
    Gene Ontology 12
    Phenotypes 23
  • Earliest
    J:13842 Nash HR, et al., Aconitase. Mouse News Lett. 1980;62:57-8
  • Latest
    J:202286 Wilkinson N, et al., IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2alpha mRNA translation. Blood. 2013 Aug 29;122(9):1658-68

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory