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Aco1
Gene Detail
 Symbol
Name
ID
Aco1
aconitase 1
MGI:87879
Synonyms Aco-1, Irebp, Irp1
Feature Type protein coding gene
Genetic Map
Chromosome 4
20.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr4:40143081-40198338 bp, + strand
From VEGA annotation of GRCm38

  55258 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1657  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: aconitase A/homoaconitase (aconitate hydratase 1)
Gene Tree: Aco1

Human
homologs
Human Homolog ACO1, aconitase 1, soluble
NCBI Gene ID 48
neXtProt AC  NX_P21399
Human Synonyms  ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1
Human Chr (Location)  9p21.1; chr9:32384603-32450836 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(5) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display no obvious phenotypic abnormalities.
 
Interactions
Aco1 interacts with 104 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cellular iron ion homeostasis, citrate metabolic process, ...
Component cell, cytoplasm, ...
Function 4 iron, 4 sulfur cluster binding, aconitate hydratase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (248)    Tissues (105)    Images (32)
Theiler Stages: 15, 22, 23
Assay TypeResults
RNA in situ 244
RT-PCR 4
cDNA source data(181)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(184) cDNA(182) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006559 (Evidence)
Ensembl Gene ModelENSMUSG00000028405 (Evidence)
Entrez Gene11428 (Evidence)
UniGene331547
DFCITC1573508, TC1645892, TC1653068, TC1654585
DoTSDT.101192465
NIA Mouse Gene IndexU042522
EC4.2.1.3
Consensus CDS ProjectCCDS18042.1
International Mouse Knockout Project StatusAco1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006559 VEGA Gene Model | MGI Sequence Detail 55258 C57BL/6J ±  kb
transcript OTTMUST00000014972 VEGA | MGI Sequence Detail 3832 Not Applicable 
polypeptide OTTMUSP00000006919 VEGA | MGI Sequence Detail 889 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(364 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha
InterPro IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
InterPro IPR015932 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2
InterPro IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel
InterPro IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel
InterPro IPR018136 Aconitase family, 4Fe-4S cluster binding site
InterPro IPR006249 Aconitase/iron regulatory protein 2
InterPro IPR015937 Aconitase/isopropylmalate dehydratase
Protein Ontology PR:000003631 cytoplasmic aconitate hydratase
References (Earliest) J:13842 Nash HR, et al., Aconitase. Mouse News Lett. 1980;62:57-8
(Latest) J:202286 Wilkinson N, et al., IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2alpha mRNA translation. Blood. 2013 Aug 29;122(9):1658-68
All references(79)
Other
accession IDs
MGD-MRK-1044, MGD-MRK-1046, MGD-MRK-11463, MGI:2140214

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory