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Aco1
Gene Detail
Symbol

Name
ID
Aco1
aconitase 1
MGI:87879
Synonyms
Aco-1, Irebp, Irp1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
20.24 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr4:40143081-40198338 bp, + strand
From VEGA annotation of GRCm38

  55258 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1657  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ACO1
Protein SuperFamily: aconitase A/homoaconitase (aconitate hydratase 1)
Gene Tree: Aco1

Human
homologs
ACO1, aconitase 1, soluble
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 48
neXtProt AC: NX_P21399

Human Synonyms: ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1

Human Chr (Location): 9p21.1; chr9:32384603-32450836 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(5) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display no obvious phenotypic abnormalities.
 
Interactions
Aco1 interacts with 104 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (37 annotations)
Process cellular iron ion homeostasis, citrate metabolic process, ...
Component cell, cytoplasm, ...
Function 4 iron, 4 sulfur cluster binding, aconitate hydratase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (248)    Tissues (105)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 244
RT-PCR 4
cDNA source data(181)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase aco1    NEW 
Molecular
reagents
All nucleic(184) cDNA(182) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000006559 (Evidence)
Ensembl Gene Model ENSMUSG00000028405 (Evidence)
Entrez Gene 11428 (Evidence)
UniGene 331547
DFCI TC1573508, TC1645892, TC1653068, TC1654585
DoTS DT.101192465
NIA Mouse Gene Index U042522
EC 4.2.1.3
Consensus CDS Project CCDS18042.1
International Mouse Phenotyping Consortium Status Aco1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006559 VEGA Gene Model | MGI Sequence Detail 55258 C57BL/6J ±  kb
transcript OTTMUST00000014972 VEGA | MGI Sequence Detail 3832 Not Applicable 
polypeptide OTTMUSP00000006919 VEGA | MGI Sequence Detail 889 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(364 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha
InterPro IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
InterPro IPR015932 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2
InterPro IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel
InterPro IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel
InterPro IPR018136 Aconitase family, 4Fe-4S cluster binding site
InterPro IPR006249 Aconitase/iron regulatory protein 2
InterPro IPR015937 Aconitase/isopropylmalate dehydratase
Protein Ontology PR:000003631 cytoplasmic aconitate hydratase
References
(Earliest) J:13842 Nash HR, et al., Aconitase. Mouse News Lett. 1980;62:57-8
(Latest) J:202286 Wilkinson N, et al., IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2alpha mRNA translation. Blood. 2013 Aug 29;122(9):1658-68
All references(73)
Other
accession IDs
MGD-MRK-1044, MGD-MRK-1046, MGD-MRK-11463, MGI:2140214

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory