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Acat2
Gene Detail
Symbol

Name
ID
Acat2
acetyl-Coenzyme A acetyltransferase 2
MGI:87871
Synonyms
Tcp1-rs1, Tcp-1x
Feature Type
protein coding gene
Genetic Map
Chromosome 17
8.73 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr17:12942890-12960747 bp, - strand
From VEGA annotation of GRCm38

  17858 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55855  Vertebrate Homology Class
1 human; 2 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ACAT2
Protein SuperFamily: acetyl-CoA acetyltransferase
Gene Tree: Acat2

Human
homologs
ACAT2, acetyl-CoA acetyltransferase 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 39
neXtProt AC: NX_Q9BWD1

Human Chr (Location): 6q25.3; chr6:159761957-159779112 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ACAT2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Acat2 interacts with 138 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process metabolic process
Component cytoplasm, cytosol, ...
Function acetyl-CoA C-acetyltransferase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (327)    Tissues (131)    Images (66)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 327
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase acat2 ; ZFIN acat2    NEW 
Molecular
reagents
All nucleic(19) Genomic(5) cDNA(14)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000028085 (Evidence)
Ensembl Gene Model ENSMUSG00000023832 (Evidence)
Entrez Gene 110460 (Evidence)
DoTS DT.101720591, DT.536009, DT.91482569
EC 2.3.1.9
Consensus CDS Project CCDS37437.1
International Mouse Phenotyping Consortium Status Acat2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028085 VEGA Gene Model | MGI Sequence Detail 17858 C57BL/6J ±  kb
transcript OTTMUST00000069567 VEGA | MGI Sequence Detail 2250 Not Applicable 
polypeptide OTTMUSP00000035353 VEGA | MGI Sequence Detail 397 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(106 from dbSNP Build 137)    SNPs within 2kb including multiple locations(160)
Protein-related
information
ResourceIDDescription
InterPro IPR002155 Thiolase
InterPro IPR020610 Thiolase, active site
InterPro IPR020613 Thiolase, conserved site
InterPro IPR020617 Thiolase, C-terminal
InterPro IPR016039 Thiolase-like
InterPro IPR016038 Thiolase-like, subgroup
InterPro IPR020616 Thiolase, N-terminal
Protein Ontology PR:000003611 acetyl-CoA acetyltransferase, cytosolic
References
(Earliest) J:8190 Willison KR, et al., Molecular cloning and sequence analysis of a haploid expressed gene encoding t complex polypeptide 1. Cell. 1986 Mar 14;44(5):727-38
(Latest) J:210054 Dixon JL, et al., Loss of beta-carotene 15,15'-oxygenase in developing mouse tissues alters esterification of retinol, cholesterol and diacylglycerols. Biochim Biophys Acta. 2014 Jan;1841(1):34-43
All references(49)
Other
accession IDs
MGD-MRK-1029, MGD-MRK-14817, MGD-MRK-14828, MGI:2147098, MGI:98537

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory