Acat2
Gene Detail

Symbol Name ID

Acat2 acetyl-Coenzyme A acetyltransferase 2 MGI:87871

Synonyms

Tcp1-rs1, Tcp-1x

Feature Type

protein coding gene

Genetic Map

Chromosome 17

8.73 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr17:12942890-12960747 bp, - strand From VEGA annotation of GRCm38   17858 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human    (Mammalian Orthology)
Comparative Map (Mouse/Human Acat2 ± 2 cM)

Protein SuperFamily: acetyl-CoA acetyltransferase
Gene Tree: Acat2

Human ortholog

ACAT2 acetyl-CoA acetyltransferase 2 NCBI Gene ID 39
Human Chr6:160182989-160200087 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human ACAT2 (1)

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	metabolic process
Component	cytoplasm, mitochondrion
Function	acetyl-CoA C-acetyltransferase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (312)    Tissues (116)    Images (65)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	312

cDNA source data(177)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(184) Genomic(5) cDNA(179)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000028085 (Evidence)
Ensembl Gene Model	ENSMUSG00000023832 (Evidence)
Entrez Gene	110460 (Evidence)
UniGene	439711
DoTS	DT.101720591, DT.536009, DT.91482569
EC	2.3.1.9
Consensus CDS Project	CCDS37437.1
International Mouse Knockout Project Status	Acat2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028085	VEGA Gene Model | MGI Sequence Detail	17858	C57BL/6J
transcript	OTTMUST00000069567	VEGA | MGI Sequence Detail	2250	Not Applicable
polypeptide	OTTMUSP00000035353	VEGA | MGI Sequence Detail	397	Not Applicable

All sequences(29) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(59 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002155	Thiolase
InterPro	IPR020610	Thiolase, active site
InterPro	IPR020613	Thiolase, conserved site
InterPro	IPR020617	Thiolase, C-terminal
InterPro	IPR016039	Thiolase-like
InterPro	IPR016038	Thiolase-like, subgroup
InterPro	IPR020616	Thiolase, N-terminal
Protein Ontology	PR:000003611	acetyl-CoA acetyltransferase, cytosolic

References

(Earliest) J:8190 Willison KR, et al., Molecular cloning and sequence analysis of a haploid expressed gene encoding t complex polypeptide 1. Cell. 1986 Mar 14;44(5):727-38
(Latest) J:185622 Rogers MA, et al., Cellular pregnenolone esterification by acyl-CoA:cholesterol acyltransferase. J Biol Chem. 2012 May 18;287(21):17483-92
All references(45)

Other accession IDs

MGD-MRK-1029, MGD-MRK-14817, MGD-MRK-14828, MGI:2147098, MGI:98537