Acat1
Gene Detail

Symbol Name ID

Acat1 acetyl-Coenzyme A acetyltransferase 1 MGI:87870

Synonyms

6330585C21Rik, Acat

Feature Type

protein coding gene

Genetic Map

Chromosome 9

29.12 cM, cytoband C-D
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr9:53580522-53610382 bp, - strand From VEGA annotation of GRCm38   29861 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; hamster, golden; rabbit, European    (Mammalian Orthology)
Comparative Map (Mouse/Human Acat1 ± 2 cM)

Protein SuperFamily: acetyl-CoA acetyltransferase
Gene Tree: Acat1

Human ortholog

ACAT1 acetyl-CoA acetyltransferase 1 NCBI Gene ID 38
Human Synonyms: ACAT, MAT, T2, THIL
Human Chr11:107992258-108018895 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human ACAT1 (1)

Alleles and phenotypes

All alleles(7) : Targeted(3) Gene trapped(4)

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	metabolic process, protein homooligomerization
Component	mitochondrial inner membrane, mitochondrial matrix, ...
Function	acetyl-CoA C-acetyltransferase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (7)    Tissues (7)   
Theiler Stages: 15, 19, 23, 26, 28

Assay Type	Results
RT-PCR	7

cDNA source data(249)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(257) Genomic(1) cDNA(252) Primer pair(2) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000036698 (Evidence)
Ensembl Gene Model	ENSMUSG00000032047 (Evidence)
Entrez Gene	110446 (Evidence)
UniGene	293233
DFCI	TC1573563
DoTS	DT.102558494, DT.87069871, DT.94299926
NIA Mouse Gene Index	U030874
EC	2.3.1.9
Consensus CDS Project	CCDS23184.1
International Mouse Knockout Project Status	Acat1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036698	VEGA Gene Model | MGI Sequence Detail	29861	C57BL/6J
transcript	OTTMUST00000094019	VEGA | MGI Sequence Detail	3405	Not Applicable
polypeptide	OTTMUSP00000052229	VEGA | MGI Sequence Detail	424	Not Applicable

All sequences(33) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(3) : SNPs(44 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002155	Thiolase
InterPro	IPR020610	Thiolase, active site
InterPro	IPR020615	Thiolase, acyl-enzyme intermediate active site
InterPro	IPR020613	Thiolase, conserved site
InterPro	IPR020617	Thiolase, C-terminal
InterPro	IPR016039	Thiolase-like
InterPro	IPR016038	Thiolase-like, subgroup
InterPro	IPR020616	Thiolase, N-terminal
Protein Ontology	PR:000003610	acetyl-CoA acetyltransferase, mitochondrial

References

(Earliest) J:8321 Leader DP, et al., Isolation and characterization of cDNA clones from mouse skeletal muscle actin mRNA. DNA. 1986 Jun;5(3):235-8
(Latest) J:185622 Rogers MA, et al., Cellular pregnenolone esterification by acyl-CoA:cholesterol acyltransferase. J Biol Chem. 2012 May 18;287(21):17483-92
All references(52)

Other accession IDs

MGD-MRK-1027, MGD-MRK-1028, MGI:2443107