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Acat1
Gene Detail
 Symbol
Name
ID
Acat1
acetyl-Coenzyme A acetyltransferase 1
MGI:87870
Synonyms 6330585C21Rik, Acat
Feature Type protein coding gene
Genetic Map
Chromosome 9
29.12 cM, cytoband C-D
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr9:53580522-53610382 bp, - strand
From VEGA annotation of GRCm38

  29861 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: acetyl-CoA acetyltransferase
Gene Tree: Acat1

Human
homologs
Human Homolog ACAT1, acetyl-CoA acetyltransferase 1
NCBI Gene ID 38
neXtProt AC  NX_P24752
Human Synonyms  ACAT, MAT, T2, THIL
Human Chr (Location)  11q22.3; chr11:108121531-108148168 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ACAT1
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Acat1 interacts with 242 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process metabolic process, protein homooligomerization
Component extracellular vesicular exosome, mitochondrial inner membrane, ...
Function acetyl-CoA C-acetyltransferase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (7)    Tissues (7)   
Theiler Stages: 15, 19, 23, 26, 28
Assay TypeResults
RT-PCR 7
cDNA source data(251)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(259) Genomic(1) cDNA(254) Primer pair(2) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000036698 (Evidence)
Ensembl Gene ModelENSMUSG00000032047 (Evidence)
Entrez Gene110446 (Evidence)
UniGene293233
DFCITC1573563
DoTSDT.102558494, DT.87069871, DT.94299926
NIA Mouse Gene IndexU030874
EC2.3.1.9
Consensus CDS ProjectCCDS23184.1
International Mouse Knockout Project StatusAcat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036698 VEGA Gene Model | MGI Sequence Detail 29861 C57BL/6J ±  kb
transcript OTTMUST00000094019 VEGA | MGI Sequence Detail 3405 Not Applicable 
polypeptide OTTMUSP00000052229 VEGA | MGI Sequence Detail 424 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(2)
Polymorphisms RFLP(3) : SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002155 Thiolase
InterPro IPR020610 Thiolase, active site
InterPro IPR020615 Thiolase, acyl-enzyme intermediate active site
InterPro IPR020613 Thiolase, conserved site
InterPro IPR020617 Thiolase, C-terminal
InterPro IPR016039 Thiolase-like
InterPro IPR016038 Thiolase-like, subgroup
InterPro IPR020616 Thiolase, N-terminal
Protein Ontology PR:000003610 acetyl-CoA acetyltransferase, mitochondrial
References (Earliest) J:8321 Leader DP, et al., Isolation and characterization of cDNA clones from mouse skeletal muscle actin mRNA. DNA. 1986 Jun;5(3):235-8
(Latest) J:185622 Rogers MA, et al., Cellular pregnenolone esterification by acyl-CoA:cholesterol acyltransferase. J Biol Chem. 2012 May 18;287(21):17483-92
All references(53)
Other
accession IDs
MGD-MRK-1027, MGD-MRK-1028, MGI:2443107

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory