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Acat1
Gene Detail
Symbol

Name
ID
Acat1
acetyl-Coenzyme A acetyltransferase 1
MGI:87870
Synonyms
6330585C21Rik, Acat
Feature Type
protein coding gene
Genetic Map
Chromosome 9
29.12 cM, cytoband C-D
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr9:53580522-53610382 bp, - strand
From VEGA annotation of GRCm38

  29861 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ACAT1
Protein SuperFamily: acetyl-CoA acetyltransferase
Gene Tree: Acat1

Human
homologs
ACAT1, acetyl-CoA acetyltransferase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 38
neXtProt AC: NX_P24752

Human Synonyms: ACAT, MAT, T2, THIL

Human Chr (Location): 11q22.3; chr11:108121531-108148168 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ACAT1

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Acat1 interacts with 241 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process metabolic process, protein homooligomerization
Component extracellular exosome, mitochondrial inner membrane, ...
Function acetyl-CoA C-acetyltransferase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (7)    Tissues (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 7
cDNA source data(251)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase acat1    NEW 
Molecular
reagents
All nucleic(259) Genomic(1) cDNA(254) Primer pair(2) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000036698 (Evidence)
Ensembl Gene Model ENSMUSG00000032047 (Evidence)
Entrez Gene 110446 (Evidence)
UniGene 293233
DFCI TC1573563
DoTS DT.102558494, DT.87069871, DT.94299926
NIA Mouse Gene Index U030874
EC 2.3.1.9
Consensus CDS Project CCDS23184.1
International Mouse Phenotyping Consortium Status Acat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036698 VEGA Gene Model | MGI Sequence Detail 29861 C57BL/6J ±  kb
transcript OTTMUST00000094019 VEGA | MGI Sequence Detail 3405 Not Applicable 
polypeptide OTTMUSP00000052229 VEGA | MGI Sequence Detail 424 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(3) : SNPs within 2kb(48 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002155 Thiolase
InterPro IPR020610 Thiolase, active site
InterPro IPR020615 Thiolase, acyl-enzyme intermediate active site
InterPro IPR020613 Thiolase, conserved site
InterPro IPR020617 Thiolase, C-terminal
InterPro IPR016039 Thiolase-like
InterPro IPR016038 Thiolase-like, subgroup
InterPro IPR020616 Thiolase, N-terminal
Protein Ontology PR:000003610 acetyl-CoA acetyltransferase, mitochondrial
References
(Earliest) J:1221 Masuno M, et al., Chromosome mapping of the human mitochondrial acetoacetyl-coenzyme A thiolase gene to 11q22.3----q23.1 by fluorescence in situ hybridization. Cytogenet Cell Genet. 1992;60(2):121-2
(Latest) J:210054 Dixon JL, et al., Loss of beta-carotene 15,15'-oxygenase in developing mouse tissues alters esterification of retinol, cholesterol and diacylglycerols. Biochim Biophys Acta. 2014 Jan;1841(1):34-43
All references(52)
Other
accession IDs
MGD-MRK-1027, MGD-MRK-1028, MGI:2443107

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory