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Acadm Gene Detail
Summary
  • Symbol
    Acadm
  • Name
    acyl-Coenzyme A dehydrogenase, medium chain
  • Synonyms
    MCAD
  • Feature Type
    protein coding gene
  • IDs
    MGI:87867
    NCBI Gene: 11364
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:153922357-153944632 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22276 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 78.77 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ACADM, acyl-CoA dehydrogenase medium chain
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ACADM, acyl-CoA dehydrogenase medium chain
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACAD1, MCAD, MCADH
  • Links
    NCBI Gene ID: 34
    neXtProt AC: NX_P11310
    UniProt: P11310

  • Chr Location
    1p31.1; chr1:75724347-75763679 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ACADM
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Acadm mouse models; 1 with human ACADM associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display a high degree of postnatal lethality, develop an organic aciduria, fatty liver and an unexpected diffuse cardiomyopathy with multifocal myocyte degeneration and necrosis, and show severe cold intolerance with prior fasting.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031346 VEGA Gene Model | MGI Sequence Detail 22276 C57BL/6J ±  kb
    transcript OTTMUST00000077658 VEGA | MGI Sequence Detail 2047 Not Applicable  
    polypeptide OTTMUSP00000041123 VEGA | MGI Sequence Detail 421 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      163 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000003601 medium-chain specific acyl-CoA dehydrogenase, mitochondrial
    • EC
    • InterPro Domains
      IPR006089 Acyl-CoA dehydrogenase, conserved site
      IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
      IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
      IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
      IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
      IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
      IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
      IPR034180 Medium-chain specific acyl-CoA dehydrogenase
    Molecular
    Reagents
    less
    • All nucleic 313
      Genomic 3
      cDNA 306
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1024, MGI:2139874
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 10
      Phenotypes 10
    • Earliest
      J:14629 Kelly DP, et al., Nucleotide sequence of medium-chain acyl-CoA dehydrogenase mRNA and its expression in enzyme-deficient human tissue. Proc Natl Acad Sci U S A. 1987 Jun;84(12):4068-72
    • Latest
      J:241230 Spitler KM, et al., Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming. Am J Physiol Heart Circ Physiol. 2017 Apr 01;312(4):H768-H780

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory