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Acadm Gene Detail
Summary
  • Symbol
    Acadm
  • Name
    acyl-Coenzyme A dehydrogenase, medium chain
  • Synonyms
    MCAD
  • Feature Type
    protein coding gene
  • IDs
    MGI:87867
    NCBI Gene: 11364
Location & Maps
more
  • Sequence Map
    Chr3:153922357-153944632 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22276 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 78.77 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ACADM, acyl-CoA dehydrogenase, C-4 to C-12 straight chain
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ACADM, acyl-CoA dehydrogenase, C-4 to C-12 straight chain
    Orthology source: HomoloGene
  • Synonyms
    ACAD1, MCAD, MCADH
  • Links
    NCBI Gene ID: 34
    neXtProt AC: NX_P11310

  • Chr Location
    1p31; chr1:75724347-75763679 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ACADM
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Acadm mouse models; 1 with human ACADM associations

Human Disease Mouse Models
       Acyl-Coa Dehydrogenase, Medium-Chain, Deficiency Of; ACADMD   OMIM: 201450 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    1 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    47
  • Gene trapped
    40
  • Targeted
    7
  • Incidental Mutations
Mice homozygous for a knock-out allele display a high degree of postnatal lethality, develop an organic aciduria, fatty liver and an unexpected diffuse cardiomyopathy with multifocal myocyte degeneration and necrosis, and show severe cold intolerance with prior fasting.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031346 VEGA Gene Model | MGI Sequence Detail 22276 C57BL/6J ±  kb
transcript OTTMUST00000077658 VEGA | MGI Sequence Detail 2047 Not Applicable  
polypeptide OTTMUSP00000041123 VEGA | MGI Sequence Detail 421 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    163 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000003601 medium-chain specific acyl-CoA dehydrogenase, mitochondrial
  • EC
  • InterPro Domains
    IPR006089 Acyl-CoA dehydrogenase, conserved site
    IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
    IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
    IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
    IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
Molecular
Reagents
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  • All nucleic 312
    Genomic 3
    cDNA 305
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-1024, MGI:2139874
References
more
  • Summaries
    All 57
    Developmental Gene Expression 14
    Diseases 1
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:14629 Kelly DP, et al., Nucleotide sequence of medium-chain acyl-CoA dehydrogenase mRNA and its expression in enzyme-deficient human tissue. Proc Natl Acad Sci U S A. 1987 Jun;84(12):4068-72
  • Latest
    J:222220 Iso T, et al., Capillary endothelial fatty acid binding proteins 4 and 5 play a critical role in fatty acid uptake in heart and skeletal muscle. Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2549-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory