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Acadm
Gene Detail
Symbol

Name
ID
Acadm
acyl-Coenzyme A dehydrogenase, medium chain
MGI:87867
Synonyms
MCAD
Feature Type
protein coding gene
Genetic Map
Chromosome 3
78.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:153922357-153944632 bp, - strand
From VEGA annotation of GRCm38

  22276 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Acadm

Human
homologs
Human Homolog ACADM, acyl-CoA dehydrogenase, C-4 to C-12 straight chain
NCBI Gene ID 34
neXtProt AC  NX_P11310
Human Synonyms  ACAD1, MCAD, MCADH
Human Chr (Location)  1p31; chr1:75724347-75763679 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ACADM
Mutations,
alleles, and
phenotypes
All mutations/alleles(46) : Gene trapped(40) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display a high degree of postnatal lethality, develop an organic aciduria, fatty liver and an unexpected diffuse cardiomyopathy with multifocal myocyte degeneration and necrosis, and show severe cold intolerance with prior fasting.
 
Human Diseases Modeled Using Mouse Acadm (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Acadm interacts with 101 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process cardiac muscle cell differentiation, carnitine biosynthetic process, ...
Component axon, extracellular vesicular exosome, ...
Function acyl-CoA dehydrogenase activity, fatty-acyl-CoA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (276)    Tissues (204)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 217
Northern blot 17
RT-PCR 42
cDNA source data(301)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(312) Genomic(3) cDNA(305) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000031346 (Evidence)
Ensembl Gene ModelENSMUSG00000062908 (Evidence)
Entrez Gene11364 (Evidence)
UniGene10530
DFCITC1572783, TC1608421, TC1636568
DoTSDT.110897825, DT.55107439, DT.94226152, DT.97339820
NIA Mouse Gene IndexU024783, U064660
EC1.3.8.7
Consensus CDS ProjectCCDS17924.1
International Mouse Knockout Project StatusAcadm
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031346 VEGA Gene Model | MGI Sequence Detail 22276 C57BL/6J ±  kb
transcript OTTMUST00000077658 VEGA | MGI Sequence Detail 2047 Not Applicable 
polypeptide OTTMUSP00000041123 VEGA | MGI Sequence Detail 421 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(2) UniProt(11)
Polymorphisms
RFLP(4) : SNPs within 2kb(172 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006089 Acyl-CoA dehydrogenase, conserved site
InterPro IPR009100 Acyl-CoA dehydrogenase/oxidase
InterPro IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
InterPro IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
InterPro IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
Protein Ontology PR:000003601 medium-chain specific acyl-CoA dehydrogenase, mitochondrial
References
(Earliest) J:14629 Kelly DP, et al., Nucleotide sequence of medium-chain acyl-CoA dehydrogenase mRNA and its expression in enzyme-deficient human tissue. Proc Natl Acad Sci U S A. 1987 Jun;84(12):4068-72
(Latest) J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
All references(58)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1024, MGI:2139874

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory