Acadm
Gene Detail

Symbol Name ID

Acadm acyl-Coenzyme A dehydrogenase, medium chain MGI:87867

Synonyms

MCAD

Feature Type

protein coding gene

Genetic Map

Chromosome 3

78.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr3:153922357-153944632 bp, - strand From VEGA annotation of GRCm38   22276 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Acadm

Human homologs

Human Homolog		ACADM, acyl-CoA dehydrogenase, C-4 to C-12 straight chain
NCBI Gene ID		34
neXtProt AC		NX_P11310
Human Synonyms		ACAD1, MCAD, MCADH
Human Chr (Location)		1p31; chr1:76190043-76229355 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human ACADM

Alleles and phenotypes

All alleles(44) : Targeted(4) Gene trapped(40)
 

Mice homozygous for a knock-out allele display a high degree of postnatal lethality, develop an organic aciduria, fatty liver and an unexpected diffuse cardiomyopathy with multifocal myocyte degeneration and necrosis, and show severe cold intolerance with prior fasting.

 
Human Diseases Modeled Using Mouse Acadm (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (46 annotations)

Process	cardiac muscle cell differentiation, carnitine biosynthetic process, ...
Component	axon, mitochondrial matrix, ...
Function	acyl-CoA dehydrogenase activity, fatty-acyl-CoA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (223)    Tissues (151)    Images (42)
Theiler Stages: 2, 3, 19, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	164
Northern blot	17
RT-PCR	42

cDNA source data(300)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(311) Genomic(3) cDNA(304) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000031346 (Evidence)
Ensembl Gene Model	ENSMUSG00000062908 (Evidence)
Entrez Gene	11364 (Evidence)
UniGene	10530
DFCI	TC1572783, TC1608421, TC1636568
DoTS	DT.110897825, DT.55107439, DT.94226152, DT.97339820
NIA Mouse Gene Index	U024783, U064660
EC	1.3.8.7
Consensus CDS Project	CCDS17924.1
International Mouse Knockout Project Status	Acadm

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031346	VEGA Gene Model | MGI Sequence Detail	22276	C57BL/6J
transcript	OTTMUST00000077658	VEGA | MGI Sequence Detail	2047	Not Applicable
polypeptide	OTTMUSP00000041123	VEGA | MGI Sequence Detail	421	Not Applicable

All sequences(50) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(4) : SNPs(92 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006089	Acyl-CoA dehydrogenase, conserved site
InterPro	IPR006092	Acyl-CoA dehydrogenase, N-terminal
InterPro	IPR009100	Acyl-CoA dehydrogenase/oxidase
InterPro	IPR009075	Acyl-CoA dehydrogenase/oxidase C-terminal
InterPro	IPR013786	Acyl-CoA dehydrogenase/oxidase, N-terminal
InterPro	IPR006091	Acyl-CoA oxidase/dehydrogenase, central domain
InterPro	IPR006090	Acyl-CoA oxidase/dehydrogenase, type 1
Protein Ontology	PR:000003601	medium-chain specific acyl-CoA dehydrogenase, mitochondrial

References

(Earliest) J:14629 Kelly DP, et al., Nucleotide sequence of medium-chain acyl-CoA dehydrogenase mRNA and its expression in enzyme-deficient human tissue. Proc Natl Acad Sci U S A. 1987 Jun;84(12):4068-72
(Latest) J:174767 Tang F, et al., Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
All references(59)

Other accession IDs

MGD-MRK-1024, MGI:2139874