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Acadl
Gene Detail
Symbol

Name
ID
Acadl
acyl-Coenzyme A dehydrogenase, long-chain
MGI:87866
Synonyms
C79855, LCAD
Feature Type
protein coding gene
Genetic Map
Chromosome 1
33.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:66830839-66863277 bp, - strand
From VEGA annotation of GRCm38

  32439 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37498  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ACADL
Gene Tree: Acadl

Human
homologs
ACADL, acyl-CoA dehydrogenase, long chain
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 33
neXtProt AC: NX_P28330

Human Synonyms: ACAD4, LCAD

Human Chr (Location): 2q34; chr2:210187990-210225491 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in reduced litter size, sudden death between 2-14 weeks of age, reduced serum glucose levels, lipid accumulation in the liver and heart, and cardiomyopathy. Heterozygous mutant animals exhibit reduced litter size.
 
Human Diseases Modeled in Mice Using Acadl (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Acadl interacts with 150 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process carnitine catabolic process, carnitine metabolic process, CoA-linked, ...
Component cytoplasm, mitochondrial matrix, ...
Function acyl-CoA dehydrogenase activity, fatty-acyl-CoA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (381)    Tissues (129)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 381
cDNA source data(267)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase acadl ; ZFIN acadl    NEW 
Molecular
reagents
All nucleic(270) cDNA(269) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000026221 (Evidence)
Ensembl Gene Model ENSMUSG00000026003 (Evidence)
Entrez Gene 11363 (Evidence)
UniGene 2445
DFCI TC1573592, TC1724864, TC1764109
DoTS DT.110887636, DT.536956
NIA Mouse Gene Index U021424
EC 1.3.8.8
Consensus CDS Project CCDS15023.1
International Mouse Phenotyping Consortium Status Acadl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026221 VEGA Gene Model | MGI Sequence Detail 32439 C57BL/6J ±  kb
transcript OTTMUST00000064849 VEGA | MGI Sequence Detail 1916 Not Applicable 
polypeptide OTTMUSP00000032245 VEGA | MGI Sequence Detail 430 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(694 from dbSNP Build 137)    SNPs within 2kb including multiple locations(696)
Protein-related
information
ResourceIDDescription
InterPro IPR006089 Acyl-CoA dehydrogenase, conserved site
InterPro IPR009100 Acyl-CoA dehydrogenase/oxidase
InterPro IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
InterPro IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
InterPro IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
Protein Ontology PR:000003600 long-chain specific acyl-CoA dehydrogenase, mitochondrial
References
(Earliest) J:25568 Hall CL, et al., Acyl coenzyme A dehydrogenases and electron-transferring flavoprotein from beef hart mitochondria. Arch Biochem Biophys. 1976 Dec;177(2):402-14
(Latest) J:216538 Diekman EF, et al., Food withdrawal lowers energy expenditure and induces inactivity in long-chain fatty acid oxidation-deficient mouse models. FASEB J. 2014 Jul;28(7):2891-900
All references(58)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-1023, MGI:2138138, MGI:2138418, MGI:2138684

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory