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Acadl
Gene Detail
 Symbol
Name
ID
Acadl
acyl-Coenzyme A dehydrogenase, long-chain
MGI:87866
Synonyms C79855, LCAD
Feature Type protein coding gene
Genetic Map
Chromosome 1
33.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:66830839-66863277 bp, - strand
From VEGA annotation of GRCm38

  32439 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37498  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Acadl

Human
homologs
Human Homolog ACADL, acyl-CoA dehydrogenase, long chain
NCBI Gene ID 33
neXtProt AC  NX_P28330
Human Synonyms  ACAD4, LCAD
Human Chr (Location)  2q34; chr2:210187908-210225491 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in reduced litter size, sudden death between 2-14 weeks of age, reduced serum glucose levels, lipid accumulation in the liver and heart, and cardiomyopathy. Heterozygous mutant animals exhibit reduced litter size.
 
Human Diseases Modeled Using Mouse Acadl (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Acadl interacts with 151 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process carnitine catabolic process, carnitine metabolic process, CoA-linked, ...
Component cytoplasm, mitochondrial matrix, ...
Function acyl-CoA dehydrogenase activity, fatty-acyl-CoA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (381)    Tissues (129)    Images (42)
Theiler Stages: 21, 22, 23
Assay TypeResults
RNA in situ 381
cDNA source data(267)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(270) cDNA(269) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026221 (Evidence)
Ensembl Gene ModelENSMUSG00000026003 (Evidence)
Entrez Gene11363 (Evidence)
UniGene2445
DFCITC1573592, TC1724864, TC1764109
DoTSDT.110887636, DT.536956
NIA Mouse Gene IndexU021424
EC1.3.8.8
Consensus CDS ProjectCCDS15023.1
International Mouse Knockout Project StatusAcadl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026221 VEGA Gene Model | MGI Sequence Detail 32439 C57BL/6J ±  kb
transcript OTTMUST00000064849 VEGA | MGI Sequence Detail 1916 Not Applicable 
polypeptide OTTMUSP00000032245 VEGA | MGI Sequence Detail 430 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(694 from dbSNP Build 137)    SNPs within 2kb including multiple locations(696)
Protein-related
information
ResourceIDDescription
InterPro IPR006089 Acyl-CoA dehydrogenase, conserved site
InterPro IPR009100 Acyl-CoA dehydrogenase/oxidase
InterPro IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
InterPro IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
InterPro IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
Protein Ontology PR:000003600 long-chain specific acyl-CoA dehydrogenase, mitochondrial
References (Earliest) J:25568 Hall CL, et al., Acyl coenzyme A dehydrogenases and electron-transferring flavoprotein from beef hart mitochondria. Arch Biochem Biophys. 1976 Dec;177(2):402-14
(Latest) J:210671 Pougovkina O, et al., Mitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidation. Hum Mol Genet. 2014 Jul 1;23(13):3513-22
All references(58)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-1023, MGI:2138138, MGI:2138418, MGI:2138684

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory