Acadl
Gene Detail

Symbol Name ID

Acadl acyl-Coenzyme A dehydrogenase, long-chain MGI:87866

Synonyms

C79855, LCAD

Feature Type

protein coding gene

Genetic Map

Chromosome 1

33.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:66830839-66863277 bp, - strand From VEGA annotation of GRCm38   32439 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37498  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Acadl

Human homologs

Human Homolog		ACADL, acyl-CoA dehydrogenase, long chain
NCBI Gene ID		33
neXtProt AC		NX_P28330
Human Synonyms		ACAD4, LCAD
Human Chr (Location)		2q34; chr2:211052714-211090215 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygous mutation of this gene results in reduced litter size, sudden death between 2-14 weeks of age, reduced serum glucose levels, lipid accumulation in the liver and heart, and cardiomyopathy. Heterozygous mutant animals exhibit reduced litter size.

 
Human Diseases Modeled Using Mouse Acadl (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	carnitine catabolic process, carnitine metabolic process, CoA-linked, ...
Component	cytoplasm, mitochondrial matrix, ...
Function	acyl-CoA dehydrogenase activity, fatty-acyl-CoA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (381)    Tissues (129)    Images (42)
Theiler Stages: 21, 22, 23

Assay Type	Results
RNA in situ	381

cDNA source data(267)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(270) cDNA(269) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000026221 (Evidence)
Ensembl Gene Model	ENSMUSG00000026003 (Evidence)
Entrez Gene	11363 (Evidence)
UniGene	2445
DFCI	TC1573592, TC1724864, TC1764109
DoTS	DT.110887636, DT.536956
NIA Mouse Gene Index	U021424
EC	1.3.8.8
Consensus CDS Project	CCDS15023.1
International Mouse Knockout Project Status	Acadl

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026221	VEGA Gene Model | MGI Sequence Detail	32439	C57BL/6J
transcript	OTTMUST00000064849	VEGA | MGI Sequence Detail	1916	Not Applicable
polypeptide	OTTMUSP00000032245	VEGA | MGI Sequence Detail	430	Not Applicable

All sequences(36) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(201 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006089	Acyl-CoA dehydrogenase, conserved site
InterPro	IPR006092	Acyl-CoA dehydrogenase, N-terminal
InterPro	IPR009100	Acyl-CoA dehydrogenase/oxidase
InterPro	IPR009075	Acyl-CoA dehydrogenase/oxidase C-terminal
InterPro	IPR013786	Acyl-CoA dehydrogenase/oxidase, N-terminal
InterPro	IPR006091	Acyl-CoA oxidase/dehydrogenase, central domain
InterPro	IPR006090	Acyl-CoA oxidase/dehydrogenase, type 1
Protein Ontology	PR:000003600	long-chain specific acyl-CoA dehydrogenase, mitochondrial

References

(Earliest) J:25568 Hall CL, et al., Acyl coenzyme A dehydrogenases and electron-transferring flavoprotein from beef hart mitochondria. Arch Biochem Biophys. 1976 Dec;177(2):402-14
(Latest) J:193325 Boj SF, et al., Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell. 2012 Dec 21;151(7):1595-607
All references(53)

Other accession IDs

MGD-MRK-1023, MGI:2138138, MGI:2138418, MGI:2138684