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Acadl Gene Detail
Summary
  • Symbol
    Acadl
  • Name
    acyl-Coenzyme A dehydrogenase, long-chain
  • Synonyms
    C79855, LCAD
  • Feature Type
    protein coding gene
  • IDs
    MGI:87866
    NCBI Gene: 11363
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:66869998-66902436 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 33.64 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    657 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87866
 protein coding gene Chr1:66869998-66902468 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016116
 protein coding gene Chr1:67088726-67120502 (-)
A/J MGP_AJ_G0016099
 protein coding gene Chr1:64719106-64749656 (-)
AKR/J MGP_AKRJ_G0016056
 protein coding gene Chr1:66565121-66598499 (-)
BALB/cJ MGP_BALBcJ_G0016054
 protein coding gene Chr1:64797631-64829980 (-)
C3H/HeJ MGP_C3HHeJ_G0015885
 protein coding gene Chr1:66817901-66849086 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016507
 protein coding gene Chr1:69680486-69711361 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014228
 protein coding gene Chr1:60649745-60680341 (-)
CAST/EiJ MGP_CASTEiJ_G0015469
 protein coding gene Chr1:66063733-66114527 (-)
CBA/J MGP_CBAJ_G0015858
 protein coding gene Chr1:71937311-71973516 (-)
DBA/2J MGP_DBA2J_G0015959
 protein coding gene Chr1:64109747-64140154 (-)
FVB/NJ MGP_FVBNJ_G0015962
 protein coding gene Chr1:63361145-63392042 (-)
LP/J MGP_LPJ_G0016031
 protein coding gene Chr1:68037282-68070079 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015982
 protein coding gene Chr1:74916103-74948362 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016554
 protein coding gene Chr1:66520082-66552843 (-)
PWK/PhJ MGP_PWKPhJ_G0015256
 protein coding gene Chr1:63508939-63541163 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015035
 protein coding gene Chr1:65982851-66015210 (-)
WSB/EiJ MGP_WSBEiJ_G0015531
 protein coding gene Chr1:66248536-66280349 (-)



Homology
more
  • Human Ortholog
    ACADL, acyl-CoA dehydrogenase long chain
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACADL, acyl-CoA dehydrogenase long chain
  • Synonyms
    ACAD4, LCAD
  • Links
    NCBI Gene ID: 33
    neXtProt AC: NX_P28330
    UniProt: P28330

  • Chr Location
    2q34; chr2:210187126-210225447 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Acadl mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    1 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in reduced litter size, sudden death between 2-14 weeks of age, reduced serum glucose levels, lipid accumulation in the liver and heart, and cardiomyopathy. Heterozygous mutant animals exhibit reduced litter size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1094
  • Tissues
    133
  • cDNA Data
    268
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026003 Ensembl Gene Model | MGI Sequence Detail 32439 C57BL/6J ±  kb
    transcript ENSMUST00000027153 Ensembl | MGI Sequence Detail 1916 Not Applicable  
    polypeptide ENSMUSP00000027153 Ensembl | MGI Sequence Detail 430 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000003600 long-chain specific acyl-CoA dehydrogenase, mitochondrial
      (term hierarchy)
    • EC
      1.3.8.8
    • InterPro Domains
      IPR006089 Acyl-CoA dehydrogenase, conserved site
      IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
      IPR009075 Acyl-CoA dehydrogenase/oxidase, C-terminal
      IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
      IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
      IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
      IPR006091 Acyl-CoA oxidase/dehydrogenase, middle domain
      IPR046373 Acyl-CoA oxidase/dehydrogenase, middle domain superfamily
      IPR034179 Long-chain specific acyl-CoA dehydrogenase
    Molecular
    Reagents
    less
    • All nucleic 272
      cDNA 270
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1023, MGI:2138138, MGI:2138418, MGI:2138684
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 10
      Phenotypes 35
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:336417 Chong D, et al., Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming. Cell Discov. 2022 Oct 11;8(1):106
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory