Abl2
Gene Detail

Symbol Name ID

Abl2 v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) MGI:87860

Synonyms

Abll, Arg

Feature Type

protein coding gene

Genetic Map

Chromosome 1

67.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr1:156558786-156649568 bp, + strand From VEGA annotation of GRCm38   90783 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5278  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, ABL type
Gene Tree: Abl2

Human homologs

Human Homolog		ABL2, v-abl Abelson murine leukemia viral oncogene homolog 2
NCBI Gene ID		27
neXtProt AC		NX_P42684
Human Synonyms		ABLL, ARG
Human Chr (Location)		1q25.2; chr1:179068462-179198819 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(71) : Targeted(3) Gene trapped(68)
 

Mice homozygous for targeted mutations that inactivate the gene display multiple behavioral abnormalities indicating neuronal defects.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	actin cytoskeleton organization, actin filament bundle assembly, ...
Component	actin cytoskeleton, cytoplasm, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (61)    Tissues (7)    Images (24)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	59
Western blot	2

cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(13) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000037114 (Evidence)
Ensembl Gene Model	ENSMUSG00000026596 (Evidence)
Entrez Gene	11352 (Evidence)
DFCI	TC1602307, TC1604470, TC1643069, TC1689647
DoTS	DT.529634, DT.87055598, DT.91358659
NIA Mouse Gene Index	U042221
EC	2.7.10.2
Consensus CDS Project	CCDS15393.1, CCDS48404.1
International Mouse Knockout Project Status	Abl2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037114	VEGA Gene Model | MGI Sequence Detail	90783	C57BL/6J
transcript	OTTMUST00000095556	VEGA | MGI Sequence Detail	3549	Not Applicable
polypeptide	OTTMUSP00000053321	VEGA | MGI Sequence Detail	1182	Not Applicable

All sequences(55) RefSeq(4) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(397 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015015	F-actin binding
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR000980	SH2 domain
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
Protein Ontology	PR:000003583	tyrosine-protein kinase ABL2

References

(Earliest) J:8517 Kruh GD, et al., A novel human gene closely related to the abl proto-oncogene. Science. 1986 Dec 19;234(4783):1545-8
(Latest) J:191030 Yaqoob U, et al., Neuropilin-1 stimulates tumor growth by increasing fibronectin fibril assembly in the tumor microenvironment. Cancer Res. 2012 Aug 15;72(16):4047-59
All references(74)

Other accession IDs

MGD-MRK-1016, MGD-MRK-1391, MGI:2138109