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Abl2
Gene Detail
Symbol

Name
ID
Abl2
v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)
MGI:87860
Synonyms
Abll, Arg
Feature Type
protein coding gene
Genetic Map
Chromosome 1
67.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:156558786-156649568 bp, + strand
From VEGA annotation of GRCm38

  90783 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5278  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, ABL type
Gene Tree: Abl2

Human
homologs
Human Homolog ABL2, ABL proto-oncogene 2, non-receptor tyrosine kinase
NCBI Gene ID 27
neXtProt AC  NX_P42684
Human Synonyms  ABLL, ARG
Human Chr (Location)  1q25.2; chr1:179099327-179229684 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(71) : Gene trapped(68) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for targeted mutations that inactivate the gene display multiple behavioral abnormalities indicating neuronal defects.
 
Interactions
Abl2 interacts with 493 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (75 annotations)
Process actin cytoskeleton organization, actin filament bundle assembly, ...
Component actin cytoskeleton, cell, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (61)    Tissues (7)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 59
Western blot 2
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(13) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000037114 (Evidence)
Ensembl Gene ModelENSMUSG00000026596 (Evidence)
Entrez Gene11352 (Evidence)
DFCITC1602307, TC1604470, TC1643069, TC1689647
DoTSDT.529634, DT.87055598, DT.91358659
NIA Mouse Gene IndexU042221
EC2.7.10.2
Consensus CDS ProjectCCDS15393.1, CCDS48404.1
International Mouse Knockout Project StatusAbl2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037114 VEGA Gene Model | MGI Sequence Detail 90783 C57BL/6J ±  kb
transcript OTTMUST00000095556 VEGA | MGI Sequence Detail 3549 Not Applicable 
polypeptide OTTMUSP00000053321 VEGA | MGI Sequence Detail 1182 Not Applicable 

For the selected sequences
All sequences(77) RefSeq(24) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(609 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015015 F-actin binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000003583 Abelson tyrosine-protein kinase 2
References
(Earliest) J:8517 Kruh GD, et al., A novel human gene closely related to the abl proto-oncogene. Science. 1986 Dec 19;234(4783):1545-8
(Latest) J:211130 Chislock EM, et al., Abl family kinases regulate endothelial barrier function in vitro and in mice. PLoS One. 2013;8(12):e85231
All references(81)
Other
accession IDs
MGD-MRK-1016, MGD-MRK-1391, MGI:2138109

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory