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Gene Detail
c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms c-Abl, E430008G22Rik
Feature Type protein coding gene
Genetic Map
Chromosome 2
21.86 cM, cytoband B
Detailed Genetic Map ± 1 cM

Mapping data(55)
Sequence Map
Chr2:31688376-31804227 bp, + strand
From VEGA annotation of GRCm38

  115852 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:3783  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Abl1

Human Homolog ABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase
NCBI Gene ID 25
neXtProt AC  NX_P00519
Human Synonyms  ABL, bcr/abl, c-ABL, c-ABL1, JTK7, p150, v-abl
Human Chr (Location)  9q34.1; chr9:130713881-130887675 (+)  GRCh38
alleles, and
All mutations/alleles(70) : Gene trapped(59) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for targeted mutations that inactivate the gene have increased perinatal and postnatal mortality and may display foreshortened crania, abnormal development of spleen, head, heart and eye, reduced B and T cell populations, and osteoporosis.
Abl1 interacts with 279 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
All GO classifications: (129 annotations)
Process actin cytoskeleton organization, actin filament branching, ...
Component actin cytoskeleton, cell leading edge, ...
Function actin filament binding, ATP binding, ...
External Resources: FuncBase
Literature Summary: (18 records)
Data Summary: Results (220)    Tissues (106)    Images (19)
Theiler Stages: 22, 24, 26, 27, 28
Assay TypeResults
RNA in situ 200
Northern blot 20
cDNA source data(221)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(246) Genomic(14) cDNA(222) Primer pair(1) Other(9)
Microarray probesets(5)
Other database
VEGA Gene ModelOTTMUSG00000012077 (Evidence)
Ensembl Gene ModelENSMUSG00000026842 (Evidence)
Entrez Gene11350 (Evidence)
DFCITC1572249, TC1602761, TC1605803, TC1610352, TC1618429, TC1626769, TC1695009, TC1695867
DoTSDT.101302203, DT.101302821, DT.101738613, DT.103568737, DT.110646684, DT.494020, DT.55162742, DT.91431484, DT.97409373, DT.99859162
NIA Mouse Gene IndexU001605
PDB1ABO, 1ABQ, 1FPU, 1IEP, 1OPJ, 1OPK, 2HZN, 2QOH, 3K5V, 3KFA, 3MSS, 3OXZ, 1M52, 2Z60, 3DK3, 3DK6, 3DK7, 3IK3, 3KF4, 3MS9, 3OY3
Consensus CDS ProjectCCDS15901.1, CCDS50563.1
International Mouse Knockout Project StatusAbl1
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012077 VEGA Gene Model | MGI Sequence Detail 115852 C57BL/6J ±  kb
transcript OTTMUST00000028740 VEGA | MGI Sequence Detail 5583 Not Applicable 
polypeptide OTTMUSP00000013004 VEGA | MGI Sequence Detail 1142 Not Applicable 

For the selected sequences
All sequences(121) RefSeq(12) UniProt(7)
Polymorphisms RFLP(11) : SNPs within 2kb(219 from dbSNP Build 137)
InterPro IPR015015 F-actin binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000003582 tyrosine-protein kinase ABL1
References (Earliest) J:6037 Risser R, et al., Abelson antigen: a viral tumor antigen that is also a differentiation antigen of BALB/c mice. Proc Natl Acad Sci U S A. 1978 Aug;75(8):3918-22
(Latest) J:211130 Chislock EM, et al., Abl family kinases regulate endothelial barrier function in vitro and in mice. PLoS One. 2013;8(12):e85231
All references(206)
accession IDs
MGD-MRK-1015, MGI:2138905, MGI:2443781

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory