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Abl1
Gene Detail
Symbol

Name
ID
Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
MGI:87859
Synonyms
c-Abl, E430008G22Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
21.86 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(55)
Sequence Map
Chr2:31688376-31804227 bp, + strand
From VEGA annotation of GRCm38

  115852 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3783  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ABL1
Gene Tree: Abl1

Human
homologs
ABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 25
neXtProt AC: NX_P00519

Human Synonyms: ABL, bcr/abl, c-ABL, c-ABL1, JTK7, p150, v-abl

Human Chr (Location): 9q34.1; chr9:130713881-130887675 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(78) : Gene trapped(59) Targeted(11) Transgenic(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for targeted mutations that inactivate the gene have increased perinatal and postnatal mortality and may display foreshortened crania, abnormal development of spleen, head, heart and eye, reduced B and T cell populations, and osteoporosis.
 
Mutations Annotated to Human Diseases (6)   
Interactions
Abl1 interacts with 279 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (139 annotations)
Process actin cytoskeleton organization, actin filament branching, ...
Component actin cytoskeleton, cell leading edge, ...
Function actin filament binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (220)    Tissues (106)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 200
Northern blot 20
cDNA source data(221)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase abl1 ; ZFIN abl1    NEW 
Molecular
reagents
All nucleic(246) Genomic(14) cDNA(222) Primer pair(1) Other(9)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000012077 (Evidence)
Ensembl Gene Model ENSMUSG00000026842 (Evidence)
Entrez Gene 11350 (Evidence)
UniGene 1318
DFCI TC1572249, TC1602761, TC1605803, TC1610352, TC1618429, TC1626769, TC1695009, TC1695867
DoTS DT.101302203, DT.101302821, DT.101738613, DT.103568737, DT.110646684, DT.494020, DT.55162742, DT.91431484, DT.97409373, DT.99859162
NIA Mouse Gene Index U001605
EC 2.7.10.2
PDB 1ABO, 1ABQ, 1FPU, 1IEP, 1OPJ, 1OPK, 2HZN, 2QOH, 3K5V, 3KFA, 3MSS, 3OXZ, 1M52, 2Z60, 3DK3, 3DK6, 3DK7, 3IK3, 3KF4, 3MS9, 3OY3
Consensus CDS Project CCDS15901.1, CCDS50563.1
International Mouse Phenotyping Consortium Status Abl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012077 VEGA Gene Model | MGI Sequence Detail 115852 C57BL/6J ±  kb
transcript OTTMUST00000028740 VEGA | MGI Sequence Detail 6327 Not Applicable 
polypeptide OTTMUSP00000013004 VEGA | MGI Sequence Detail 1142 Not Applicable 

For the selected sequences
All sequences(131) RefSeq(14) UniProt(10)
Polymorphisms
RFLP(11) : SNPs within 2kb(219 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015015 F-actin binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000003582 tyrosine-protein kinase ABL1
References
(Earliest) J:6037 Risser R, et al., Abelson antigen: a viral tumor antigen that is also a differentiation antigen of BALB/c mice. Proc Natl Acad Sci U S A. 1978 Aug;75(8):3918-22
(Latest) J:210101 Mahul-Mellier AL, et al., c-Abl phosphorylates alpha-synuclein and regulates its degradation: implication for alpha-synuclein clearance and contribution to the pathogenesis of Parkinson's disease. Hum Mol Genet. 2014 Jun 1;23(11):2858-79
All references(203)
Other
accession IDs
MGD-MRK-1015, MGI:2138905, MGI:2443781

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory