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Abl1
Gene Detail
Symbol

Name
ID
Abl1
c-abl oncogene 1, non-receptor tyrosine kinase
MGI:87859
Synonyms
c-Abl, E430008G22Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
21.86 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(55)
Sequence Map
Chr2:31688376-31804227 bp, + strand
From VEGA annotation of GRCm38

  115852 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3783  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Abl1

Human
homologs
Human Homolog ABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase
NCBI Gene ID 25
neXtProt AC  NX_P00519
Human Synonyms  ABL, bcr/abl, c-ABL, c-ABL1, JTK7, p150, v-abl
Human Chr (Location)  9q34.1; chr9:130713881-130887675 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(70) : Gene trapped(59) Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for targeted mutations that inactivate the gene have increased perinatal and postnatal mortality and may display foreshortened crania, abnormal development of spleen, head, heart and eye, reduced B and T cell populations, and osteoporosis.
 
Interactions
Abl1 interacts with 279 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (137 annotations)
Process actin cytoskeleton organization, actin filament branching, ...
Component actin cytoskeleton, cell leading edge, ...
Function actin filament binding, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (220)    Tissues (106)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 200
Northern blot 20
cDNA source data(221)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(246) Genomic(14) cDNA(222) Primer pair(1) Other(9)
Microarray probesets(5)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012077 VEGA Gene Model | MGI Sequence Detail 115852 C57BL/6J ±  kb
transcript OTTMUST00000028740 VEGA | MGI Sequence Detail 5583 Not Applicable 
polypeptide OTTMUSP00000013004 VEGA | MGI Sequence Detail 1142 Not Applicable 

For the selected sequences
All sequences(127) RefSeq(12) UniProt(13)
Polymorphisms
RFLP(11) : SNPs within 2kb(219 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015015 F-actin binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000003582 tyrosine-protein kinase ABL1
References
(Earliest) J:6037 Risser R, et al., Abelson antigen: a viral tumor antigen that is also a differentiation antigen of BALB/c mice. Proc Natl Acad Sci U S A. 1978 Aug;75(8):3918-22
(Latest) J:211130 Chislock EM, et al., Abl family kinases regulate endothelial barrier function in vitro and in mice. PLoS One. 2013;8(12):e85231
All references(207)
Other
accession IDs
MGD-MRK-1015, MGI:2138905, MGI:2443781

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory