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Abl1 Gene Detail
Summary
  • Symbol
    Abl1
  • Name
    c-abl oncogene 1, non-receptor tyrosine kinase
  • Synonyms
    c-Abl, E430008G22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:87859
    NCBI Gene: 11350
  • Gene Overview
    MyGene.info: ABL1
Location & Maps
more
  • Sequence Map
    Chr2:31688376-31804227 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      115852 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 21.86 cM, cytoband B
  • Mapping Data
    55 experiments
Homology
more
  • Human Ortholog
    ABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ABL1, ABL proto-oncogene 1, non-receptor tyrosine kinase
    Orthology source: HomoloGene
  • Synonyms
    ABL, bcr/abl, c-ABL, c-ABL1, JTK7, p150, v-abl
  • Links
    NCBI Gene ID: 25
    neXtProt AC: NX_P00519

  • Chr Location
    9q34.1; chr9:130713881-130887675 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3783
    1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ABL1
  • Gene Tree
Human Diseases
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  • Mutations/Alleles
    6 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    75 phenotypes from 10 alleles in 12 genetic backgrounds
    76 phenotypes from multigenic genotypes
    114 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene have increased perinatal and postnatal mortality and may display foreshortened crania, abnormal development of spleen, head, heart and eye, reduced B and T cell populations, and osteoporosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012077 VEGA Gene Model | MGI Sequence Detail 115852 C57BL/6J ±  kb
transcript OTTMUST00000028740 VEGA | MGI Sequence Detail 6327 Not Applicable  
polypeptide OTTMUSP00000013004 VEGA | MGI Sequence Detail 1142 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    219 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 246
    Genomic 14
    cDNA 222
    Primer pair 1
    Other 9

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-1015, MGI:2138905, MGI:2443781
References
more
  • Summaries
    All 206
    Developmental Gene Expression 18
    Diseases 8
    Gene Ontology 46
    Phenotypes 114
  • Earliest
    J:6037 Risser R, et al., Abelson antigen: a viral tumor antigen that is also a differentiation antigen of BALB/c mice. Proc Natl Acad Sci U S A. 1978 Aug;75(8):3918-22
  • Latest
    J:232550 Brahmachari S, et al., Activation of tyrosine kinase c-Abl contributes to alpha-synuclein-induced neurodegeneration. J Clin Invest. 2016 Jun 27;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory