Pzp
Gene Detail

Symbol Name ID

Pzp pregnancy zone protein MGI:87854

STS

D6Uwa7

Feature Type

protein coding gene

Genetic Map

Chromosome 6

63.02 cM, cytoband F1-G3
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr6:128483573-128526720 bp, - strand From VEGA annotation of GRCm38   43148 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Pzp ± 2 cM)

Protein SuperFamily: alpha-2-macroglobulin
Gene Tree: Pzp

Human ortholog

PZP pregnancy-zone protein NCBI Gene ID 5858
Human Synonyms: CPAMD6
Human Chr12:9301436-9360966 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygotes for a null allele show higher bone mineral density, hypoactivity, and decreased heart rate. Homozygotes for a different null allele show increased resistance to endotoxin challenge, impaired LPS-induced febrile and TNF responses, and increased susceptibility to diet-induced pancreatitis.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	negative regulation of endopeptidase activity, negative regulation of peptidase activity
Component	extracellular region, extracellular space, ...
Function	endopeptidase inhibitor activity, peptidase inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (63)    Tissues (16)    Images (22)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	19
Northern blot	44

cDNA source data(154)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(178) Genomic(23) cDNA(154) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000022212 (Evidence)
Ensembl Gene Model	ENSMUSG00000030359 (Evidence)
Entrez Gene	11287 (Evidence)
UniGene	260144
DFCI	TC1574462
DoTS	DT.101279079, DT.40177193
NIA Mouse Gene Index	U027900
Consensus CDS Project	CCDS39650.1
International Mouse Knockout Project Status	Pzp

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022212	VEGA Gene Model | MGI Sequence Detail	43148	C57BL/6J
transcript	OTTMUST00000052790	VEGA | MGI Sequence Detail	4695	Not Applicable
polypeptide	OTTMUSP00000025075	VEGA | MGI Sequence Detail	1507	Not Applicable

All sequences(30) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(193 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001599	Alpha-2-macroglobulin
InterPro	IPR019742	Alpha-2-macroglobulin, conserved site
InterPro	IPR002890	Alpha-2-macroglobulin, N-terminal
InterPro	IPR011625	Alpha-2-macroglobulin, N-terminal 2
InterPro	IPR019565	Alpha-2-macroglobulin, thiol-ester bond-forming
InterPro	IPR009048	Alpha-macroglobulin, receptor-binding
InterPro	IPR011626	A-macroglobulin complement component
InterPro	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid

References

(Earliest) J:30074 Greene ND, et al., The identification of alpha-2-macroglobulin in the mouse. Biochim Biophys Acta. 1971 Jun 29;236(3):659-63
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(51)

Other accession IDs

MGD-MRK-1006, MGI:2141514