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Pzp
Gene Detail
 Symbol
Name
ID
Pzp
pregnancy zone protein
MGI:87854
STS D6Uwa7
Feature Type protein coding gene
Genetic Map
Chromosome 6
63.02 cM, cytoband F1-G3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr6:128483573-128526720 bp, - strand
From VEGA annotation of GRCm38

  43148 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:104112  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: alpha-2-macroglobulin
Gene Tree: Pzp

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a null allele show higher bone mineral density, hypoactivity, and decreased heart rate. Homozygotes for a different null allele show increased resistance to endotoxin challenge, impaired LPS-induced febrile and TNF responses, and increased susceptibility to diet-induced pancreatitis.
 
Interactions
Pzp interacts with 114 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process embryo implantation, negative regulation of endopeptidase activity, ...
Component extracellular region, extracellular space
Function endopeptidase inhibitor activity, peptidase inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (63)    Tissues (17)    Images (22)
Theiler Stages: 23, 27, 28
Assay TypeResults
RNA in situ 19
Northern blot 44
cDNA source data(155)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(179) Genomic(23) cDNA(155) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000022212 (Evidence)
Ensembl Gene ModelENSMUSG00000030359 (Evidence)
Entrez Gene11287 (Evidence)
UniGene260144
DFCITC1574462
DoTSDT.101279079, DT.40177193
NIA Mouse Gene IndexU027900
Consensus CDS ProjectCCDS39650.1
International Mouse Knockout Project StatusPzp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022212 VEGA Gene Model | MGI Sequence Detail 43148 C57BL/6J ±  kb
transcript OTTMUST00000052790 VEGA | MGI Sequence Detail 4695 Not Applicable 
polypeptide OTTMUSP00000025075 VEGA | MGI Sequence Detail 1507 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(323 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001599 Alpha-2-macroglobulin
InterPro IPR019742 Alpha-2-macroglobulin, conserved site
InterPro IPR002890 Alpha-2-macroglobulin, N-terminal
InterPro IPR011625 Alpha-2-macroglobulin, N-terminal 2
InterPro IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming
InterPro IPR009048 Alpha-macroglobulin, receptor-binding
InterPro IPR011626 A-macroglobulin complement component
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
References (Earliest) J:30074 Greene ND, et al., The identification of alpha-2-macroglobulin in the mouse. Biochim Biophys Acta. 1971 Jun 29;236(3):659-63
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(50)
Other
accession IDs
MGD-MRK-1006, MGI:2141514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory