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Pzp Gene Detail
Summary
  • Symbol
    Pzp
  • Name
    PZP, alpha-2-macroglobulin like
  • Feature Type
    protein coding gene
  • IDs
    MGI:87854
    NCBI Gene: 11287
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:128483567-128526720 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.02 cM, cytoband F1-G3
  • Mapping Data
    1 experiment
  • Sequence Tag
    D6Uwa7
Strain
Comparison
more
  • SNPs within 2kb
    319 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_87854
 protein coding gene Chr6:128483567-128526720 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031328
 protein coding gene Chr6:132104830-132152285 (-)
A/J MGP_AJ_G0031299
 protein coding gene Chr6:127028816-127072916 (-)
AKR/J MGP_AKRJ_G0031227
 protein coding gene Chr6:130446051-130495648 (-)
BALB/cJ MGP_BALBcJ_G0031306
 protein coding gene Chr6:126604042-126648090 (-)
C3H/HeJ MGP_C3HHeJ_G0031030
 protein coding gene Chr6:130596465-130646086 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031765
 protein coding gene Chr6:135533686-135584033 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028911
 protein coding gene Chr6:124239797-124283991 (-)
CAST/EiJ MGP_CASTEiJ_G0030411
 protein coding gene Chr6:130887636-130940380 (-)
CBA/J MGP_CBAJ_G0030991
 protein coding gene Chr6:140778894-140829522 (-)
DBA/2J MGP_DBA2J_G0031147
 protein coding gene Chr6:125926166-125971223 (-)
FVB/NJ MGP_FVBNJ_G0031097
 protein coding gene Chr6:124852940-124897229 (-)
LP/J MGP_LPJ_G0031227
 protein coding gene Chr6:132216372-132266020 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031135
 protein coding gene Chr6:144600076-144645326 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031798
 protein coding gene Chr6:130462927-130508478 (-)
PWK/PhJ MGP_PWKPhJ_G0030126
 protein coding gene Chr6:124223197-124267289 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029955
 protein coding gene Chr6:128586977-128638795 (-)
WSB/EiJ MGP_WSBEiJ_G0030496
 protein coding gene Chr6:130862149-130911859 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 2 alleles in 4 genetic backgrounds
    18 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes mutant null mice show higher bone mineral density, hypoactivity, and decreased heart rate. Mice homozygous for a different null allele show resistance to the lethal effects of endotoxin, increased susceptibility to diet-induced acute pancreatitis, and altered LPS-induced febrile and cytokine responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    63
  • Tissues
    17
  • cDNA Data
    156
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11287 NCBI Gene Model | MGI Sequence Detail 43154 C57BL/6J ±  kb
    transcript NM_007376 RefSeq | MGI Sequence Detail 4681 Not Specified  
    polypeptide Q61838 UniProt | EBI | MGI Sequence Detail 1495 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR001599 Alpha-2-macroglobulin
      IPR011625 Alpha-2-macroglobulin, bait region domain
      IPR019742 Alpha-2-macroglobulin, conserved site
      IPR041813 Alpha-2-macroglobulin, TED domain
      IPR011626 Alpha-macroglobulin-like, TED domain
      IPR009048 Alpha-macroglobulin, receptor-binding
      IPR036595 Alpha-macroglobulin, receptor-binding domain superfamily
      IPR014756 Immunoglobulin E-set
      IPR013783 Immunoglobulin-like fold
      IPR002890 Macroglobulin domain
      IPR041555 Macroglobulin domain MG3
      IPR040839 Macroglobulin domain MG4
      IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
    Molecular
    Reagents
    less
    • All nucleic 180
      Genomic 23
      cDNA 156
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1006, MGI:2141514
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:30074 Greene ND, et al., The identification of alpha-2-macroglobulin in the mouse. Biochim Biophys Acta. 1971 Jun 29;236(3):659-63
    • Latest
      J:265607 Naba A, et al., Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Sci Rep. 2017 Jan 10;7:40495
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/26/2019
    MGI 6.14     		The Jackson Laboratory