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Pzp Gene Detail
Summary
  • Symbol
    Pzp
  • Name
    PZP, alpha-2-macroglobulin like
  • Feature Type
    protein coding gene
  • IDs
    MGI:87854
    NCBI Gene: 11287
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr6:128483567-128526720 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      43154 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.02 cM, cytoband F1-G3
  • Mapping Data
    1 experiment
  • Sequence Tag
    D6Uwa7
Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 2 alleles in 4 genetic backgrounds
    18 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes mutant null mice show higher bone mineral density, hypoactivity, and decreased heart rate. Mice homozygous for a different null allele show resistance to the lethal effects of endotoxin, increased susceptibility to diet-induced acute pancreatitis, and altered LPS-induced febrile and cytokine responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    63
  • Tissues
    17
  • cDNA Data
    156
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022212 VEGA Gene Model | MGI Sequence Detail 43154 C57BL/6J ±  kb
    transcript OTTMUST00000052790 VEGA | MGI Sequence Detail 4681 Not Applicable  
    polypeptide OTTMUSP00000025075 VEGA | MGI Sequence Detail 1495 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      319 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR001599 Alpha-2-macroglobulin
      IPR019742 Alpha-2-macroglobulin, conserved site
      IPR002890 Alpha-2-macroglobulin, N-terminal
      IPR011625 Alpha-2-macroglobulin, N-terminal 2
      IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming
      IPR011626 Alpha-macroglobulin complement component
      IPR009048 Alpha-macroglobulin, receptor-binding
      IPR036595 Alpha-macroglobulin, receptor-binding domain superfamily
      IPR014756 Immunoglobulin E-set
      IPR013783 Immunoglobulin-like fold
      IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
    Molecular
    Reagents
    less
    • All nucleic 180
      Genomic 23
      cDNA 156
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1006, MGI:2141514
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:30074 Greene ND, et al., The identification of alpha-2-macroglobulin in the mouse. Biochim Biophys Acta. 1971 Jun 29;236(3):659-63
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/31/2018
    MGI 6.12     		The Jackson Laboratory