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Sorbs1 Gene Detail
Summary
  • Symbol
    Sorbs1
  • Name
    sorbin and SH3 domain containing 1
  • Synonyms
    2310065E01Rik, 9530001P15Rik, CAP, c-Cbl-associated protein, mKIAA1296, Ponsin, Sh3d5
  • Feature Type
    protein coding gene
  • IDs
    MGI:700014
    NCBI Gene: 20411
  • Gene Overview
    MyGene.info: SORBS1
Location & Maps
more
  • Sequence Map
    Chr19:40295049-40402267 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      107219 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 34.25 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SORBS1, sorbin and SH3 domain containing 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SORBS1, sorbin and SH3 domain containing 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAP, FLAF2, R85FL, SH3D5, SH3P12, SORB1
  • Links
    NCBI Gene ID: 10580
    neXtProt AC: NX_Q9BX66

  • Chr Location
    10q24.1; chr10:95311773-95561420 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased triglyceride levels, altered glucose homeostasis, decreased white blood cells and resistance to developing glucose intolerance induced by a high fat diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025006 Ensembl Gene Model | MGI Sequence Detail 107219 C57BL/6J ±  kb
transcript ENSMUST00000099467 Ensembl | MGI Sequence Detail 2817 Not Applicable  
polypeptide ENSMUSP00000097066 Ensembl | MGI Sequence Detail 938 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1609 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 21
    Primer pair 5
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:1922938, MGI:2443814
References
more
  • Summaries
    All 49
    Developmental Gene Expression 10
    Gene Ontology 11
    Phenotypes 7
  • Earliest
    J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
  • Latest
    J:231595 Gurdziel K, et al., Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory