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Sorbs3 Gene Detail
Summary
  • Symbol
    Sorbs3
  • Name
    sorbin and SH3 domain containing 3
  • Synonyms
    Sh3d4, SH3P3, vinexin alpha, vinexin beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:700013
    NCBI Gene: 20410
  • Gene Overview
    MyGene.info: SORBS3
Location & Maps
more
  • Sequence Map
    Chr14:70180468-70207637 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27170 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SORBS3, sorbin and SH3 domain containing 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    SORBS3, sorbin and SH3 domain containing 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SCAM1, SCAM-1, SH3D4
  • Links
    NCBI Gene ID: 10174
    neXtProt AC: NX_O60504

  • Chr Location
    8p21.3; chr8:22544990-22575495 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Sorbs3
  • Incidental Mutations
Homozygous mutants are generally normal, viable, and fertile, except showing delayed wound healing in response to full-thickness skin injury in vivo.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022091 Ensembl Gene Model | MGI Sequence Detail 27170 C57BL/6J ±  kb
transcript ENSMUST00000022682 Ensembl | MGI Sequence Detail 2914 Not Applicable  
polypeptide ENSMUSP00000022682 Ensembl | MGI Sequence Detail 733 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    190 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 36
    cDNA 36

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
  • Latest
    J:224556 Li M, et al., Vinexin-beta deficiency protects against cerebral ischaemia/reperfusion injury by inhibiting neuronal apoptosis. J Neurochem. 2015 Jul;134(2):211-21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory