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Ostf1 Gene Detail
Summary
  • Symbol
    Ostf1
  • Name
    osteoclast stimulating factor 1
  • Synonyms
    C78236, Sh3d3, SH3P2
  • Feature Type
    protein coding gene
  • IDs
    MGI:700012
    NCBI Gene: 20409
  • Gene Overview
    MyGene.info: OSTF1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:18580364-18631813 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 13.17 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    728 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_700012
protein coding gene Chr19:18579328-18631813 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024966
protein coding gene Chr19:16449286-16506008 (-)
A/J MGP_AJ_G0024943
protein coding gene Chr19:15528423-15580542 (-)
AKR/J MGP_AKRJ_G0024913
protein coding gene Chr19:16144905-16199664 (-)
BALB/cJ MGP_BALBcJ_G0024942
protein coding gene Chr19:15558722-15611234 (-)
C3H/HeJ MGP_C3HHeJ_G0024700
protein coding gene Chr19:16085902-16137572 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025384
protein coding gene Chr19:17035924-17092204 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022803
protein coding gene Chr19:15897860-15951993 (-)
CAST/EiJ MGP_CASTEiJ_G0024168
protein coding gene Chr19:15717014-15779126 (-)
CBA/J MGP_CBAJ_G0024678
protein coding gene Chr19:17652102-17711792 (-)
DBA/2J MGP_DBA2J_G0024810
protein coding gene Chr19:15556114-15608396 (-)
FVB/NJ MGP_FVBNJ_G0024771
protein coding gene Chr19:15475075-15526812 (-)
LP/J MGP_LPJ_G0024894
protein coding gene Chr19:16423423-16479545 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024798
protein coding gene Chr19:17535376-17590965 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025439
protein coding gene Chr19:16080391-16132405 (-)
PWK/PhJ MGP_PWKPhJ_G0023917
protein coding gene Chr19:15094545-15148143 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023722
protein coding gene Chr19:15365106-15419089 (-)
WSB/EiJ MGP_WSBEiJ_G0024236
protein coding gene Chr19:16127871-16182308 (-)



Homology
more
  • Human Ortholog
    OSTF1, osteoclast stimulating factor 1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    OSTF1, osteoclast stimulating factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA235O14.1, OSF, SH3P2
  • Links
    NCBI Gene ID: 26578
    neXtProt AC: NX_Q92882
    UniProt: Q92882

  • Chr Location
    9q21.13; chr9:75088480-75147201 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8227
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;3 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: OSTF1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout results in increased trabecular number and bone density in the femur and tibia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20409 NCBI Gene Model | MGI Sequence Detail 51450 C57BL/6J ±  kb
    transcript NM_017375 RefSeq | MGI Sequence Detail 1714 C57BL/6  
    polypeptide Q62422 UniProt | EBI | MGI Sequence Detail 215 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 92
      cDNA 92

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2147784
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
    • Latest
      J:249839 Vermeren M, et al., Osteoclast stimulation factor 1 (Ostf1) KNOCKOUT increases trabecular bone mass in mice. Mamm Genome. 2017 Dec;28(11-12):498-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory