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Sh3gl1
Gene Detail
Symbol

Name
ID
Sh3gl1
SH3-domain GRB2-like 1
MGI:700010
Synonyms
EEN, endophilin II, Sh3d2b, SH3P8
Feature Type
protein coding gene
Genetic Map
Chromosome 17
29.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:56016753-56036637 bp, - strand
From Ensembl annotation of GRCm38

  19885 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55709  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sh3gl1

Human
homologs
Human Homolog SH3GL1, SH3-domain GRB2-like 1
NCBI Gene ID 6455
neXtProt AC  NX_Q99961
Human Synonyms  CNSA1, EEN, SH3D2B, SH3P8
Human Chr (Location)  19p13.3; chr19:4360367-4400568 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(30) : Gene trapped(23) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit normal life span and no obvious phenotypic defects. Mice homozygous for knock-out alleles of Sh3gl1-3 exhibit neonatal lethality, respiratory distress, absence of gastric milk, abnormal synaptic transmission and abnormal synaptic vesicle recycling.
 
Interactions
Sh3gl1 interacts with 96 markers (Mir24-1, Mir24-2, Mir29a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process endocytosis
Component cell junction, cell projection, ...
Function GTPase binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (44)    Tissues (33)    Images (12)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 36
Northern blot 8
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000003200 (Evidence)
Entrez Gene20405 (Evidence)
NIA Mouse Gene IndexU037935
Consensus CDS ProjectCCDS28891.1
International Mouse Knockout Project StatusSh3gl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003200 Ensembl Gene Model | MGI Sequence Detail 19885 C57BL/6J ±  kb
transcript ENSMUST00000003268 Ensembl | MGI Sequence Detail 2072 Not Applicable 
polypeptide ENSMUSP00000003268 Ensembl | MGI Sequence Detail 368 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(7)
Polymorphisms
RFLP(2) : SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027267 Arfaptin homology (AH) domain/BAR domain
InterPro IPR004148 BAR domain
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000014823 endophilin-A2
References
(Earliest) J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
(Latest) J:194200 Soda K, et al., Role of dynamin, synaptojanin, and endophilin in podocyte foot processes. J Clin Invest. 2012 Dec 3;122(12):4401-11
All references(43)
Other
accession IDs
MGI:2147117

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory